Publications by authors named "MJ LaMarche"

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The Logic of Chemical Optimization.
David C Kombo, Matthew J LaMarche

J Med Chem· June 2025

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Application of artificial intelligence and machine learning techniques to the analysis of dynamic protein sequences.
David C Kombo, Matthew J LaMarche, Chilaluck C Konkankit, S Rackovsky

Proteins· October 2024

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Predictions of Colloidal Molecular Aggregation Using AI/ML Models.
David C Kombo, J David Stepp, Sungtaek Lim, Bettina Elshorst, Yi Li, Matthew J LaMarche

ACS Omega· July 2024

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Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
Michael Visser, Julien P N Papillon, Michael Luzzio, Matthew J LaMarche, Jianmei Fan

J Med Chem· January 2024

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Think Biologically, Act Chemically.
Matthew J LaMarche

J Med Chem· September 2022

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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling.
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Matthew J LaMarche

Elife· March 2021

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Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling.
Chen Liu, Hengyu Lu, Hongyun Wang, Alice Loo, Xiamei Zhang, Matthew J LaMarche

Clin Cancer Res· January 2021

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SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms.
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Matthew J LaMarche

Sci Rep· January 2021

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
Matthew J LaMarche, Michael Acker, Andreea Argintaru, Daniel Bauer, Julie Boisclair

J Med Chem· November 2020

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Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR.
Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew J LaMarche

Oncotarget· January 2020

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Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers.
Huai-Xiang Hao, Hongyun Wang, Chen Liu, Steven Kovats, Roberto Velazquez, Matthew J LaMarche

Mol Cancer Ther· December 2019

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Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
Jeffrey T Bagdanoff, Zhouliang Chen, Michael Acker, Ying-Nan Chen, Homan Chan, Matthew J LaMarche

J Med Chem· April 2019

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Correction to 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Patrick Sarver, Michael Acker, Jeffrey T Bagdanoff, Zhouliang Chen, Ying-Nan Chen, Matthew J LaMarche

J Med Chem· April 2019

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6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Patrick Sarver, Michael Acker, Jeffrey T Bagdanoff, Zhouliang Chen, Ying-Nan Chen, Matthew J LaMarche

J Med Chem· February 2019

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
Jeffrey T Bagdanoff, Zhouliang Chen, Michael Acker, Ying-Nan Chen, Homan Chan, Matthew J LaMarche

J Med Chem· February 2019

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Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
Jonathan R LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli, Morvarid Mohseni, Ping Wang, Matthew J LaMarche

Nat Commun· October 2018

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Dual Allosteric Inhibition of SHP2 Phosphatase.
Michelle Fodor, Edmund Price, Ping Wang, Hengyu Lu, Andreea Argintaru, Matthew J LaMarche

ACS Chem Biol· March 2018

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Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Jonathan R LaRochelle, Michelle Fodor, Jana M Ellegast, Xiaoxi Liu, Vidyasiri Vemulapalli, Matthew J LaMarche

Bioorg Med Chem· December 2017

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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Jorge Garcia Fortanet, Christine Hiu-Tung Chen, Ying-Nan P Chen, Zhouliang Chen, Zhan Deng, Matthew J LaMarche

J Med Chem· September 2016

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Antibacterial and Solubility Optimization of Thiomuracin A.
Matthew J LaMarche, Jennifer A Leeds, Jason Brewer, Karl Dean, Jian Ding

J Med Chem· July 2016

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan, Peter Fekkes, Jorge Garcia-Fortanet

Nature· July 2016

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Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Jonathan R LaRochelle, Michelle Fodor, Xiang Xu, Izabela Durzynska, Lixin Fan, Matthew J LaMarche

Biochemistry· April 2016

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Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space.
Audrey G Ross, Bret M Benton, Donovan Chin, Gianfranco De Pascale, John Fuller, Matthew J LaMarche

Bioorg Med Chem Lett· September 2015

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2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.
Erin P Keaney, Michael Connolly, Markus Dobler, Rajeshri Karki, Ayako Honda, Matthew J LaMarche

Bioorg Med Chem Lett· August 2014

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Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.
M J Lamarche, J Borawski, A Bose, C Capacci-Daniel, R Colvin

Antimicrob Agents Chemother· October 2012

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