Publications by authors named "Ma Yangchun"

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Quercetin-derived microbial metabolite DOPAC potentiates CD8 T cell anti-tumor immunity via NRF2-mediated mitophagy.
Penghu Han, Shuzheng Chu, Jing Shen, Lixiang Li, Yan Zhang, Yangchun Ma

Cell Metab· December 2025

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Novel 1-Methylquinazoline and 1-Methylquinoxaline derivatives targeting FtsZ protein: Potent antibacterial agents against gram-positive bacteria.
ShenYan Zhang, Hang Ding, Yangchun Ma, Yue Kong, Ting Guo

Bioorg Chem· December 2025

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Design, synthesis and biological evaluation of 3,3-dimethyl-2,3,4,9-tetrahydro-1H-carbazole derivatives as AcrB inhibitors with potent antibiofilm effect for reversing bacterial multidrug resistance.
Ting Guo, Jiale Dong, Yangchun Ma, Weijin Chen, Jie Xue

Bioorg Chem· October 2025

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Design, synthesis and biological evaluation of Meucin-18 derived peptides as efficient broad-spectrum antibacterial agents.
Xiaohong Chang, Yangchun Ma, Xianghui Zhang, Shenyan Zhang, Bingfang Bai

Bioorg Chem· August 2025

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Design, Synthesis, and Bioactivity Evaluation of Novel 1-Methyl-2-phenylpyridin-1-ium Derivatives as Broad-Spectrum FtsZ Inhibitors.
Yangchun Ma, Yue Kong, Hang Ding, Ting Guo, Weijin Chen

J Agric Food Chem· February 2025

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Design, Synthesis, and Biological Evaluation of 2-Phenoxyalkylhydrazide Benzoxazole Derivatives as Quorum Sensing Inhibitors with Strong Antibiofilm Effect.
Panpan Zhang, Yangchun Ma, Yingmei Wang, Enhui Dong, Shutao Ma

J Med Chem· April 2024

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New broad-spectrum and potent antibacterial agents with dual-targeting mechanism: Promoting FtsZ polymerization and disrupting bacterial membranes.
Yangchun Ma, Xiaohong Chang, Shenyan Zhang, Panpan Zhang, Ting Guo

Eur J Med Chem· January 2024

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Design and Synthesis of 4-Fluorophenyl-5-methylene-2(5)-furanone Derivatives as Potent Quorum Sensing Inhibitors.
Panpan Zhang, Weijin Chen, Yang-Chun Ma, Bingfang Bai, Guanglin Sun

J Med Chem· July 2023

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Exploration of the inhibitory mechanism of PC190723 on FtsZ protein by molecular dynamics simulation.
Yangchun Ma, Shenyan Zhang, Liang Zhou, Long Zhang, Panpan Zhang

J Mol Graph Model· July 2022

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Exploring the cause of the dual allosteric targeted inhibition attaching to allosteric sites enhancing SHP2 inhibition.
Ma Yangchun, Yang WenYu, Zhou Liang, Li LiPeng, Wu JingWei

Mol Divers· June 2022

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Acridinium-conjugated aromatic heterocycles as highly potent FtsZ inhibitors: Design, synthesis, and biological evaluation.
Di Song, Nan Zhang, Yangchun Ma, Shenyan Zhang, Weijin Chen

Arch Pharm (Weinheim)· June 2022

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Design, synthesis, biological evaluation and molecular dynamics simulation studies of imidazolidine-2,4-dione derivatives as novel PTP1B inhibitors.
Yangchun Ma, Ting-Ting Ding, Ya-Ya Liu, Zhi-Hui Zheng, Su-Xia Sun

Biochem Biophys Res Commun· November 2021

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Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2.
Shan Du, Xin-Hua Lu, Wei-Ya Li, Li-Peng Li, Yang-Chun Ma

Mol Divers· August 2021

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Design, synthesis, biological evaluation and molecular dynamics of LAR inhibitors.
Ying-Zhan Sun, Jing-Wei Wu, Shan Du, Yang-Chun Ma, Liang Zhou

Comput Biol Chem· June 2021

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Exploring the mechanism of the potent allosteric inhibitor compound2 on SHP2 and SHP2 by molecular dynamics study.
Liang Zhou, Yong Feng, Yang-Chun Ma, Zhao Zhang, Jing-Wei Wu

J Mol Graph Model· March 2021

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Identification of the potential dual inhibitor of protein tyrosine phosphatase sigma and leukocyte common antigen-related phosphatase by virtual screen, molecular dynamic simulations and post-analysis.
Liang Zhou, Yang-Chun Ma, Xue Tang, Wei-Ya Li, Ying Ma

J Biomol Struct Dyn· January 2021

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Scaffold-based selective SHP2 inhibitors design using core hopping, molecular docking, biological evaluation and molecular simulation.
Wei-Ya Li, Ying Ma, Hao-Xin Li, Xin-Hua Lu, Shan Du

Bioorg Chem· December 2020

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Identification of novel inhibitor of protein tyrosine phosphatases delta: structure-based pharmacophore modeling, virtual screening, flexible docking, molecular dynamics simulation, and post-molecular dynamics analysis.
Yang-Chun Ma, Bing Yang, Xin Wang, Liang Zhou, Wei-Ya Li

J Biomol Struct Dyn· September 2020

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Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.
Wen-Shan Liu, Bing Yang, Rui-Rui Wang, Wei-Ya Li, Yang-Chun Ma

Bioorg Chem· July 2020

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Identification of protein tyrosine phosphatase 1B (PTP1B) inhibitors through De Novo Evoluton, synthesis, biological evaluation and molecular dynamics simulation.
Jingwei Wu, Yangchun Ma, Hui Zhou, Liang Zhou, Shan Du

Biochem Biophys Res Commun· May 2020

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Exploring the cause of the inhibitor 4AX attaching to binding site disrupting protein tyrosine phosphatase 4A1 trimerization by molecular dynamic simulation.
Li Wei-Ya, Duan Yu-Qing, Ma Yang-Chun, Lu Xin-Hua, Ma Ying

J Biomol Struct Dyn· November 2019

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