Publications by authors named "Malcolm Clench"

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Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response.
Sophie M Pearce, Neil A Cross, David P Smith, Malcolm R Clench, Lucy E Flint

Metabolites· May 2024

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Spatially Resolved Quantitation of Drug in Skin Equivalents Using Mass Spectrometry Imaging (MSI).
Cristina Russo, Malcolm R Clench

Methods Mol Biol· July 2023

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The Adaptation of the QV600 LLI Milli-Fluidics System to House Ex Vivo Gastrointestinal Tissue Suitable for Drug Absorption and Permeation Studies, Utilizing MALDI MSI and LC-MS/MS.
Chloe E Spencer, Catherine J Duckett, Stephen Rumbelow, Malcolm R Clench

Methods Mol Biol· July 2023

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Perspective: Mass Spectrometry Imaging - The Next 5 Years.
Malcolm R Clench, Laura M Cole

Methods Mol Biol· July 2023

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Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA-ICP-TOFMS Imaging.
Oana M Voloaca, Malcolm R Clench, Gunda Koellensperger, Laura M Cole, Sarah L Haywood-Small

Anal Chem· February 2022

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Adaptation of the Kirkstall QV600 LLI Microfluidics System for the Study of Gastrointestinal Absorption by Mass Spectrometry Imaging and LC-MS/MS.
Chloe E Spencer, Stephen Rumbelow, Steve Mellor, Catherine J Duckett, Malcolm R Clench

Pharmaceutics· February 2022

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Role of MALDI-MSI in combination with 3D tissue models for early stage efficacy and safety testing of drugs and toxicants.
Chloe E Spencer, Lucy E Flint, Catherine J Duckett, Laura M Cole, Neil Cross, Malcolm R Clench

Expert Rev Proteomics· October 2021

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Multi-Modal Mass Spectrometric Imaging of Uveal Melanoma.
Laura M Cole, Joshua Handley, Emmanuelle Claude, Catherine J Duckett, Hardeep S Mudhar, Malcolm R Clench

Metabolites· August 2021

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Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.
Lucy E Flint, Gregory Hamm, Joseph D Ready, Stephanie Ling, Catherine J Duckett, Malcolm R Clench

Metabolites· July 2021

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Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging.
Roberto Angelini, Eylan Yutuc, Mark F Wyatt, Jillian Newton, Fowzi A Yusuf, Malcolm R Clench

Anal Chem· March 2021

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Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin.
Anne Mette Handler, Gitte Pommergaard Pedersen, Kim Troensegaard Nielsen, Christian Janfelt, Anders Just Pedersen, Malcolm R Clench

Eur J Pharm Biopharm· February 2021

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Monitoring the three-dimensional distribution of endogenous species in the lungs by matrix-assisted laser desorption/ionization mass spectrometry imaging.
Bryn Flinders, Josie Morrell, Peter S Marshall, Lisa E Ranshaw, Ron M A Heeren, Malcolm R Clench

Rapid Commun Mass Spectrom· January 2021

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Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model.
Narciso Couto, Jillian R A Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Malcolm R Clench

Drug Metab Dispos· January 2021

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Localization and Composition of Fructans in Stem and Rhizome of Weber var. azul.
Arely V Pérez-López, June Simpson, Malcolm R Clench, Alan D Gomez-Vargas, José J Ordaz-Ortiz

Front Plant Sci· January 2021

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Laser ablation inductively coupled plasma mass spectrometry as a novel clinical imaging tool to detect asbestos fibres in malignant mesothelioma.
Oana M Voloaca, Calum J Greenhalgh, Laura M Cole, Malcolm R Clench, Amy J Managh

Rapid Commun Mass Spectrom· November 2020

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Pre-validation of a MALDI MS proteomics-based method for the reliable detection of blood and blood provenance.
Katie Kennedy, Cameron Heaton, Glenn Langenburg, Laura Cole, Tom Clark, Malcolm R Clench

Sci Rep· October 2020

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Characterization of an Aggregated Three-Dimensional Cell Culture Model by Multimodal Mass Spectrometry Imaging.
Lucy E Flint, Gregory Hamm, Joseph D Ready, Stephanie Ling, Catherine J Duckett, Malcolm R Clench

Anal Chem· September 2020

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Mass spectrometry imaging of endogenous metabolites in response to doxorubicin in a novel 3D osteosarcoma cell culture model.
Ieva Palubeckaitė, Lucy Crooks, David P Smith, Laura M Cole, Heijs Bram, Malcolm R Clench

J Mass Spectrom· April 2020

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Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.
Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina Pikuleva, Malcolm R Clench

Proc Natl Acad Sci U S A· March 2020

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Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance.
Maria Jove, Jade Spencer, Malcolm Clench, Paul M Loadman, Chris Twelves

Crit Rev Oncol Hematol· September 2019

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Quantitative Investigation of Terbinafine Hydrochloride Absorption into a Living Skin Equivalent Model by MALDI-MSI.
Cristina Russo, Neil Brickelbank, Catherine Duckett, Steve Mellor, Stephen Rumbelow, Malcolm R Clench

Anal Chem· August 2018

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Discrimination of papillary thyroid cancer from non-cancerous thyroid tissue based on lipid profiling by mass spectrometry imaging.
Anna Wojakowska, Laura M Cole, Mykola Chekan, Katarzyna Bednarczyk, Magdalena Maksymiak, Malcolm R Clench

Endokrynol Pol· July 2018

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Mass Spectrometry Imaging of 3D Tissue Models.
Cristina Russo, Emily E L Lewis, Lucy Flint, Malcolm R Clench

Proteomics· July 2018

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Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging.
John G Swales, Alex Dexter, Gregory Hamm, Anna Nilsson, Nicole Strittmatter, Malcolm R Clench

Anal Chem· May 2018

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The Investigation of Unexpected Arsenic Compounds Observed in Routine Biological Monitoring Urinary Speciation Analysis.
Elizabeth Leese, Malcolm Clench, Jackie Morton, Philip H E Gardiner, Vikki A Carolan

Toxics· May 2017

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