Publications by authors named "Malcolm Hetheridge"

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Determination of the zebrafish embryo developmental toxicity assessment (ZEDTA) as an alternative non-mammalian approach for the safety assessment of agrochemicals.
Jonathan S Ball, Anna Tochwin, Matthew J Winter, Maciej Trznadel, Richard Currie, Malcolm J Hetheridge

Reprod Toxicol· March 2025

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Elevated temperature exacerbates pharmaceutical-induced oxidative stress in zebrafish (Danio rerio) larvae.
Rebekah Boreham, Jonathan S Ball, Malcolm Hetheridge, Stewart Owen, Maciej Trznadel

Sci Total Environ· November 2024

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Exposure Effects of Environmentally Relevant Concentrations of the Tricyclic Antidepressant Amitriptyline in Early Life Stage Zebrafish.
Sophie L Gould, Matthew J Winter, Maciej Trznadel, Anke Lange, Charles M Hamilton, Malcolm J Hetheridge

Environ Sci Technol· July 2024

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A Combined Human and CRISPR/Cas9-Mediated Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation.
Matthew J Winter, Yosuke Ono, Jonathan S Ball, Anna Walentinsson, Erik Michaelsson, Malcolm J Hetheridge

Front Pharmacol· April 2022

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Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms.
Matthew J Winter, Joseph Pinion, Anna Tochwin, Aya Takesono, Jonathan S Ball, Malcolm J Hetheridge

Br J Pharmacol· July 2021

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Cardiovascular Effects and Molecular Mechanisms of Bisphenol A and Its Metabolite MBP in Zebrafish.
A Ross Brown, Jon M Green, John Moreman, Lina M Gunnarsson, Sulayman Mourabit, Malcolm J Hetheridge

Environ Sci Technol· January 2019

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Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.
Matthew J Winter, Dylan Windell, Jeremy Metz, Peter Matthews, Joe Pinion, Malcolm J Hetheridge

Sci Rep· October 2018

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Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.
Matthew G Baron, Kate S Mintram, Stewart F Owen, Malcolm J Hetheridge, A John Moody

PLoS One· August 2017

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4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.
Matthew J Winter, Dylan Windell, Jeremy Metz, Peter Matthews, Joe Pinion, Malcolm J Hetheridge

Sci Rep· July 2017

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A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function.
Thomas Parker, Paul-Antoine Libourel, Malcolm J Hetheridge, Robert I Cumming, Thomas P Sutcliffe

J Pharmacol Toxicol Methods· September 2014

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Fishing for teratogens: a consortium effort for a harmonized zebrafish developmental toxicology assay.
Jonathan S Ball, Donald B Stedman, Jedd M Hillegass, Cindy X Zhang, Julie Panzica-Kelly, Malcolm Hetheridge

Toxicol Sci· May 2014

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In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol.
Abigail E Bartram, Matthew J Winter, Duane B Huggett, Paul McCormack, Lisa A Constantine, Malcolm J Hetheridge

Environ Toxicol· October 2012

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The value of repeating studies and multiple controls: replicated 28-day growth studies of rainbow trout exposed to clofibric acid.
Stewart F Owen, Duane B Huggett, Thomas H Hutchinson, Malcolm J Hetheridge, Paul McCormack

Environ Toxicol Chem· December 2010

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Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges.
Matthew J Winter, Stewart F Owen, Richard Murray-Smith, Grace H Panter, Malcolm J Hetheridge

Integr Environ Assess Manag· January 2010

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Comparative aquatic toxicity of propranolol and its photodegraded mixtures: algae and rotifer screening.
Qin-Tao Liu, Tim D Williams, Rob I Cumming, Gisela Holm, Malcolm J Hetheridge

Environ Toxicol Chem· December 2009

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Genetic variation, inbreeding and chemical exposure--combined effects in wildlife and critical considerations for ecotoxicology.
A Ross Brown, David J Hosken, François Balloux, Lisa K Bickley, Gareth LePage, Malcolm J Hetheridge

Philos Trans R Soc Lond B Biol Sci· November 2009

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Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry.
Stewart F Owen, Duane B Huggett, Thomas H Hutchinson, Malcolm J Hetheridge, Lewis B Kinter

Aquat Toxicol· July 2009

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Assessing chronic toxicity of bisphenol A to larvae of the African clawed frog (Xenopus laevis) in a flow-through exposure system.
Daniel B Pickford, Malcolm J Hetheridge, John E Caunter, A Tilghman Hall, Thomas H Hutchinson

Chemosphere· October 2003

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