Publications by authors named "Malcolm Low"

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Highly Conserved STAT3 Motifs Present in the Neuronal Pomc Enhancer nPE1 are Critical for Maximal Hypothalamic Pomc Expression.
Clara E Hael, Malcolm J Low, Lucía F Franchini, Marcelo Rubinstein

Mol Neurobiol· November 2025

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Using genAI in education: the case for critical thinking.
Chien Ching Lee, Malcolm Yoke Hean Low

Front Artif Intell· November 2024

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The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.
Hui Yu, Angelika Chiang, Marcelo Rubinstein, Malcolm J Low

Mol Metab· September 2024

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A mammalian tripartite enhancer cluster controls hypothalamic expression, food intake, and body weight.
Daniela Rojo, Clara E Hael, Agustina Soria, Flávio S J de Souza, Malcolm J Low

Proc Natl Acad Sci U S A· April 2024

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Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
Nicole L Eliason, Lynne Martin, Malcolm J Low, Amanda L Sharpe

Neuropeptides· December 2022

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The G209R mutant mouse as a model for human PCSK1 polyendocrinopathy.
Manita Shakya, Surbhi Gahlot, Nicolle K Martin, Anoop Arunagiri, Martin G Martin, Malcolm J Low

Endocrinology· March 2022

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Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.
Hui Yu, Marcelo Rubinstein, Malcolm J Low

Elife· January 2022

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Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency.
Surbhi, Gábor Wittmann, Malcolm J Low, Ronald M Lechan

Mol Metab· November 2021

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Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer.
Elisa S Na, Daniel D Lam, Eva Yokosawa, Jessica M Adams, David P Olson, Malcolm J Low

PLoS One· March 2021

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Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity.
Manita Shakya, Surbhi Gahlot, Anne White, C Bruce Verchere, Malcolm J Low

Endocrinology· March 2021

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Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.
Hui Yu, Kavaljit H Chhabra, Zoe Thompson, Graham L Jones, Sylee Kiran, Malcolm J Low

Mol Metab· May 2020

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Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy.
Hui Yu, Zoe Thompson, Sylee Kiran, Graham L Jones, Lakshmi Mundada, Malcolm J Low

J Endocrinol· April 2020

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The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight.
Clara E Hael, Daniela Rojo, Daniela P Orquera, Malcolm J Low, Marcelo Rubinstein

Mol Metab· April 2020

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Selective Restoration of Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network.
Graham L Jones, Gábor Wittmann, Eva B Yokosawa, Hui Yu, Aaron J Mercer, Malcolm J Low

eNeuro· March 2020

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Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking.
Yan Zhou, Yupu Liang, Malcolm J Low, Mary J Kreek

Genes Brain Behav· November 2019

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Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D.
Timothy S Jarvela, Manita Shakya, Tomas Bachor, Anne White, Malcolm J Low

Endocrinology· November 2019

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Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice.
Yan Zhou, Francesco Leri, Malcolm J Low, Mary Jeanne Kreek

Pharmacol Biochem Behav· June 2019

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The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and Activates Expression in the Developing Hypothalamus.
Daniela P Orquera, M Belén Tavella, Flavio S J de Souza, Sofía Nasif, Malcolm J Low

J Neurosci· May 2019

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Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity.
Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy

ACS Chem Neurosci· April 2019

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Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice.
Benjamin P Tooke, Hui Yu, Jessica M Adams, Graham L Jones, Talisha Sutton-Kennedy, Malcolm J Low

Mol Metab· February 2019

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Electrical stimulation of renal nerves for modulating urine glucose excretion in rats.
Ahmad A Jiman, Kavaljit H Chhabra, Alfor G Lewis, Paul S Cederna, Randy J Seeley, Malcolm J Low

Bioelectron Med· May 2018

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Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.
Geun Hyang Kim, Guojun Shi, Diane Rm Somlo, Leena Haataja, Soobin Song, Malcolm J Low

J Clin Invest· March 2018

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17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.
Frederik J Steyn, Shyuan T Ngo, Vicky Ping Chen, Lora C Bailey-Downs, Teresa Y Xie, Malcolm J Low

Aging Cell· February 2018

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V1b Receptor Antagonist SSR149415 and Naltrexone Synergistically Decrease Excessive Alcohol Drinking in Male and Female Mice.
Yan Zhou, Marcelo Rubinstein, Malcolm J Low, Mary Jeanne Kreek

Alcohol Clin Exp Res· January 2018

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Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.
Kavaljit H Chhabra, Donald A Morgan, Benjamin P Tooke, Jessica M Adams, Kamal Rahmouni, Malcolm J Low

Mol Metab· October 2017

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