Publications by authors named "Malcolm Spain"

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I
Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR).
Mojdeh Dinarvand, Malcolm Spain

Antibiotics (Basel)· March 2021

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Pharmacodynamic Functions of Synthetic Derivatives for Treatment of Methicillin-Resistant (MRSA) and .
Mojdeh Dinarvand, Malcolm P Spain, Fatemeh Vafaee

Front Microbiol· November 2020

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Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.
Malcolm Spain, Joseph K-H Wong, Gayathri Nagalingam, James M Batten, Elinor Hortle

J Med Chem· April 2018

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Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis.
Mingfeng Yu, Gayathri Nagalingam, Samantha Ellis, Elena Martinez, Vitali Sintchenko, Malcolm Spain

J Med Chem· June 2016

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Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.
Guy Rouquet, Dianna E Moore, Malcolm Spain, Daniel M Allwood, Claudio Battilocchio

ACS Med Chem Lett· March 2015

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Mechanism of SmI2/amine/H2O-promoted chemoselective reductions of carboxylic acid derivatives (esters, acids, and amides) to alcohols.
Michal Szostak, Malcolm Spain, Andrew J Eberhart, David J Procter

J Org Chem· December 2014

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Switching between reaction pathways by an alcohol cosolvent effect: SmI2-ethylene glycol vs SmI2-H2O mediated synthesis of uracils.
Michal Szostak, Malcolm Spain, Brice Sautier, David J Procter

Org Lett· November 2014

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Selective synthesis of α,α-dideuterio alcohols by the reduction of carboxylic acids using SmI2 and D2O as deuterium source under SET conditions.
Michal Szostak, Malcolm Spain, David J Procter

Org Lett· October 2014

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Mechanistic investigation of the selective reduction of Meldrum's acids to β-hydroxy acids using SmI2 and H2O.
Michal Szostak, Sarah E Lyons, Malcolm Spain, David J Procter

Chem Commun (Camb)· August 2014

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Ketyl-type radicals from cyclic and acyclic esters are stabilized by SmI2(H2O)n: the role of SmI2(H2O)n in post-electron transfer steps.
Michal Szostak, Malcolm Spain, David J Procter

J Am Chem Soc· June 2014

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On the role of pre- and post-electron-transfer steps in the SmI2 /amine/H(2)O-mediated reduction of esters: new mechanistic insights and kinetic studies.
Michal Szostak, Malcolm Spain, David J Procter

Chemistry· April 2014

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Determination of the effective redox potentials of SmI₂, SmBr₂, SmCl₂, and their complexes with water by reduction of aromatic hydrocarbons. Reduction of anthracene and stilbene by samarium(II) iodide-water complex.
Michal Szostak, Malcolm Spain, David J Procter

J Org Chem· March 2014

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Highly chemoselective reduction of amides (primary, secondary, tertiary) to alcohols using SmI2/amine/H2O under mild conditions.
Michal Szostak, Malcolm Spain, Andrew J Eberhart, David J Procter

J Am Chem Soc· February 2014

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Electron transfer reduction of nitriles using SmI2-Et3N-H2O: synthetic utility and mechanism.
Michal Szostak, Brice Sautier, Malcolm Spain, David J Procter

Org Lett· February 2014

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Recent advances in the chemoselective reduction of functional groups mediated by samarium(II) iodide: a single electron transfer approach.
Michal Szostak, Malcolm Spain, David J Procter

Chem Soc Rev· December 2013

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Selective reduction of barbituric acids using SmI2/H2O: synthesis, reactivity, and structural analysis of tetrahedral adducts.
Michal Szostak, Brice Sautier, Malcolm Spain, Maike Behlendorf, David J Procter

Angew Chem Int Ed Engl· November 2013

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Substrate-directable electron transfer reactions. Dramatic rate enhancement in the chemoselective reduction of cyclic esters using SmI2-H2O: mechanism, scope, and synthetic utility.
Michal Szostak, Malcolm Spain, Kimberly A Choquette, Robert A Flowers, David J Procter

J Am Chem Soc· October 2013

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Uncovering the importance of proton donors in TmI2-promoted electron transfer: facile C-N bond cleavage in unactivated amides.
Michal Szostak, Malcolm Spain, David J Procter

Angew Chem Int Ed Engl· July 2013

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A general electron transfer reduction of lactones using SmI2-H2O.
Michal Szostak, Karl D Collins, Neal J Fazakerley, Malcolm Spain, David J Procter

Org Biomol Chem· August 2012

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Lactone radical cyclizations and cyclization cascades mediated by SmI2-H2O.
Dixit Parmar, Hiroshi Matsubara, Kieran Price, Malcolm Spain, David J Procter

J Am Chem Soc· August 2012

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Preparation of samarium(II) iodide: quantitative evaluation of the effect of water, oxygen, and peroxide content, preparative methods, and the activation of samarium metal.
Michal Szostak, Malcolm Spain, David J Procter

J Org Chem· April 2012

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S
Selective synthesis of 3-hydroxy acids from Meldrum's acids using SmI2-H2O.
Michal Szostak, Malcolm Spain, David J Procter

Nat Protoc· April 2012

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Electron transfer reduction of carboxylic acids using SmI2-H2O-Et3N.
Michal Szostak, Malcolm Spain, David J Procter

Org Lett· February 2012

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Selective reductive transformations using samarium diiodide-water.
Michal Szostak, Malcolm Spain, Dixit Parmar, David J Procter

Chem Commun (Camb)· January 2012

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Electron transfer reduction of unactivated esters using SmI2-H2O.
Michal Szostak, Malcolm Spain, David J Procter

Chem Commun (Camb)· October 2011

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