Publications by authors named "Malkit Sami"

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Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
Christopher J Holland, Rory M Crean, Johanne M Pentier, Ben de Wet, Angharad Lloyd, Malkit Sami

J Clin Invest· May 2020

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TCR-induced alteration of primary MHC peptide anchor residue.
Florian Madura, Pierre J Rizkallah, Mateusz Legut, Christopher J Holland, Anna Fuller, Malkit Sami

Eur J Immunol· July 2019

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Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.
Luke A McNeill, Toby J N Brown, Malkit Sami, Ian J Clifton, Nicolai I Burzlaff

Chemistry· September 2017

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Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Marine C C Raman, Pierre J Rizkallah, Ruth Simmons, Zoe Donnellan, Joseph Dukes, Malkit Sami

Sci Rep· January 2016

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T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
David K Cole, Kim M Miles, Florian Madura, Christopher J Holland, Andrea J A Schauenburg, Malkit Sami

J Biol Chem· January 2014

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T-cell receptor specificity maintained by altered thermodynamics.
Florian Madura, Pierre J Rizkallah, Kim M Miles, Christopher J Holland, Anna M Bulek, Malkit Sami

J Biol Chem· June 2013

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Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.
David K Cole, Malkit Sami, Daniel R Scott, Pierre J Rizkallah, Oleg Y Borbulevych

Front Immunol· June 2013

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Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
Emmet McCormack, Katherine J Adams, Namir J Hassan, Akhil Kotian, Nikolai M Lissin, Malkit Sami

Cancer Immunol Immunother· April 2013

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Monoclonal TCR-redirected tumor cell killing.
Nathaniel Liddy, Giovanna Bossi, Katherine J Adams, Anna Lissina, Tara M Mahon, Malkit Sami

Nat Med· June 2012

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High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activation.
Ruth K Moysey, Yi Li, Samantha J Paston, Emma E Baston, Malkit S Sami

Protein Cell· December 2010

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T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.
David K Cole, Steven M Dunn, Malkit Sami, Jonathan M Boulter, Bent K Jakobsen

Mol Immunol· May 2008

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Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.
Fang Yuan, Theonie Georgiou, Theresa Hillon, Emma Gostick, David A Price, Malkit Sami

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2007

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Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry.
Malkit Sami, Pierre J Rizkallah, Steve Dunn, Peter Molloy, Ruth Moysey

Protein Eng Des Sel· August 2007

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Human TCR-binding affinity is governed by MHC class restriction.
David K Cole, Nicholas J Pumphrey, Jonathan M Boulter, Malkit Sami, John I Bell

J Immunol· May 2007

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Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.
David K Cole, Pierre J Rizkallah, Jonathan M Boulter, Malkit Sami, Anne-lise Vuidepot

Proteins· April 2007

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Steven M Dunn, Pierre J Rizkallah, Emma Baston, Tara Mahon, Brian Cameron, Malkit Sami

Protein Sci· April 2006

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Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
David K Cole, Pierre J Rizkallah, Feng Gao, Neil I Watson, Jonathan M Boulter, Malkit Sami

Eur J Immunol· January 2006

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Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
Ji-Li Chen, Guillaume Stewart-Jones, Giovanna Bossi, Nikolai M Lissin, Linda Wooldridge, Malkit Sami

J Exp Med· April 2005

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Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.
David K Cole, Pierre J Rizkallah, Malkit Sami, Nikolai M Lissin, Feng Gao

Acta Crystallogr Sect F Struct Biol Cryst Commun· March 2005

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Stable, soluble T-cell receptor molecules for crystallization and therapeutics.
Jonathan M Boulter, Meir Glick, Penio T Todorov, Emma Baston, Malkit Sami

Protein Eng· September 2003

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