Publications by authors named "Mamoru Tasaki"

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Discovery of KRAS(G12D) selective degrader ASP3082.
Tomohiro Yoshinari, Takeyuki Nagashima, Hiroki Ishioka, Kohei Inamura, Yoshihiro Nishizono, Mamoru Tasaki

Commun Chem· August 2025

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IL-7 coupled with IL-12 increases intratumoral T cell clonality, leading to complete regression of non-immunogenic tumors.
Mamoru Tasaki, Midori Yamashita, Yukinori Arai, Takafumi Nakamura, Shinsuke Nakao

Cancer Immunol Immunother· December 2021

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Oncolytic vaccinia virus induces a novel phenotype of CD8 effector T cells characterized by high ICOS expression.
Midori Yamashita, Mamoru Tasaki, Ryuji Murakami, Yukinori Arai, Takafumi Nakamura

Mol Ther Oncolytics· March 2021

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Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade.
Shinsuke Nakao, Yukinori Arai, Mamoru Tasaki, Midori Yamashita, Ryuji Murakami

Sci Transl Med· January 2020

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Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions.
Shigeki Kunikawa, Akira Tanaka, Yuji Takasuna, Mamoru Tasaki, Noboru Chida

Bioorg Med Chem· March 2019

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A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model.
Shigeki Kunikawa, Akira Tanaka, Yuji Takasuna, Mamoru Tasaki, Noboru Chida

Bioorg Med Chem· November 2018

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Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation.
Hidehiko Fukahori, Noboru Chida, Masashi Maeda, Mamoru Tasaki, Tomoko Kawashima

Int Immunopharmacol· August 2015

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Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.
Shigeki Kunikawa, Akira Tanaka, Koichiro Mukoyoshi, Shinya Nagashima, Hiroaki Tominaga, Mamoru Tasaki

Bioorg Med Chem· July 2015

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Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity.
Hidehiko Fukahori, Noboru Chida, Masashi Maeda, Mamoru Tasaki, Tomoko Kawashima

Eur J Pharmacol· December 2014

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Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of "chemoattractant receptor homologous molecule expressed on Th2 cells" (CRTH2).
Mamoru Tasaki, Miki Kobayashi, Yoshiyuki Tenda, Susumu Tsujimoto, Shoko Nakazato

Eur J Pharm Sci· June 2013

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Leber's hereditary optic neuropathy with 14484 mutation in Central Java, Indonesia.
Tomoki Nishioka, Mamoru Tasaki, Augustinus Soemantri, Marbaniati Dyat, J C Susanto

J Hum Genet· October 2003

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