Publications by authors named "Man-Ching Leung"

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The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM.
Nicoletta Piroddi, E Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Man Ching Leung

J Gen Physiol· January 2019

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Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.
Andrew E Messer, Christopher R Bayliss, Mohammed El-Mezgueldi, Charles S Redwood, Douglas G Ward, Man-Ching Leung

Arch Biochem Biophys· July 2016

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Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.
Massimiliano Memo, Man-Ching Leung, Douglas G Ward, Cristobal dos Remedios, Sachio Morimoto

Cardiovasc Res· July 2013

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Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease.
Christopher Toepfer, Valentina Caorsi, Thomas Kampourakis, Markus B Sikkel, Timothy G West, Man-Ching Leung

J Biol Chem· May 2013

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Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Christopher R Bayliss, Adam M Jacques, Man-Ching Leung, Douglas G Ward, Charles S Redwood

Cardiovasc Res· March 2013

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Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils.
Man-Ching Leung, Paul G Hitchen, Douglas G Ward, Andrew E Messer, Steven B Marston

J Biol Chem· February 2013

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Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.
Weihua Song, Emma Dyer, Daniel J Stuckey, O'Neal Copeland, Man-Ching Leung

J Biol Chem· August 2011

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Trichohyalin is a potential major autoantigen in human alopecia areata.
Man Ching Leung, Chris W Sutton, David A Fenton, Desmond J Tobin

J Proteome Res· October 2010

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Investigation of a transgenic mouse model of familial dilated cardiomyopathy.
Weihua Song, Emma Dyer, Daniel Stuckey, Man-Ching Leung, Massimiliano Memo

J Mol Cell Cardiol· September 2010

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