Publications by authors named "Man-Sun Sy"

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Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via reduced expression of occludin.
Miao Xu, Run Shi, Jie Yang, Heng Chen, Shihua Liu, Man-Sun Sy

Acta Biochim Biophys Sin (Shanghai)· October 2024

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Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein into pro-PrP via the ATF6-miR449c-5p-PIGV axis.
JingFeng Li, SaSa Li, ShuPei Yu, Jie Yang, JingRu Ke, Man-Sun Sy

J Biol Chem· August 2023

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GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.
Shan-Shan Gao, Run Shi, Jing Sun, Yanhong Tang, Zhenhua Zheng, Man-Sun Sy

iScience· December 2022

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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.
Huan Li, Jie Zhang, Jing-Ru Ke, Ze Yu, Run Shi, Man-Sun Sy

Cell Rep· December 2022

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Targeting type I collagen for cancer treatment.
Run Shi, Zhe Zhang, Ankai Zhu, Xingxing Xiong, Jie Zhang, Man-Sun Sy

Int J Cancer· September 2022

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Tumor Necrosis Factor α Reduces SNAP29 Dependent Autolysosome Formation to Increase Prion Protein Level and Promote Tumor Cell Migration.
Huan Li, Ren Wang, Ze Yu, Run Shi, Jie Zhang, Man-Sun Sy

Virol Sin· June 2021

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Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death.
Ming Shao, Run Shi, Zhen-Xing Gao, Shan-Shan Gao, Jing-Feng Li, Man-Sun Sy

Front Oncol· May 2021

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Melanoma migration is promoted by prion protein via Akt-hsp27 signaling axis.
Jingru Ke, Guiru Wu, Jie Zhang, Huan Li, Shanshan Gao, Man-Sun Sy

Biochem Biophys Res Commun· March 2020

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Prion dimer is heterogenous and is modulated by multiple negative and positive motifs.
Zhenxing Gao, Jing Shi, Lili Cai, Minhua Luo, Boon-Seng Wong, Man-Sun Sy

Biochem Biophys Res Commun· February 2019

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CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Huixia Zhang, Chao Zhang, Hong Tang, Shanshan Gao, Fang Sun, Man-Sun Sy

Hepatology· November 2018

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Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production.
Gui-Ru Wu, Tian-Chen Mu, Zhen-Xing Gao, Jun Wang, Man-Sun Sy

J Biol Chem· November 2017

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Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.
Laura Cracco, Silvio Notari, Ignazio Cali, Man-Sun Sy, Shu G Chen

Sci Rep· January 2017

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Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1.
Yiwei Wang, Shuiliang Yu, Dan Huang, Min Cui, Huankai Hu, Man-Sun Sy

Am J Pathol· November 2016

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Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.
Chun-Lun Ni, Divya Seth, Fabio Vasconcelos Fonseca, Liwen Wang, Tsan Sam Xiao, Man-Sun Sy

PLoS One· September 2016

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Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.
Zhenxing Gao, Huixia Zhang, Fei Hu, Liheng Yang, Xiaowen Yang, Man-Sun Sy

Cell Signal· June 2016

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Glycosylphosphatidylinositol anchor modification machinery deficiency is responsible for the formation of pro-prion protein (PrP) in BxPC-3 cells and increases cancer cell motility.
Liheng Yang, Zhenxing Gao, Lipeng Hu, Guiru Wu, Xiaowen Yang, Man-Sun Sy

J Biol Chem· March 2016

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Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility.
Liheng Yang, Zhenxing Gao, Lipeng Hu, Guiru Wu, Xiaowen Yang, Man-Sun Sy

J Biol Chem· February 2016

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Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints.
Minrong Ai, Yajun Cui, Man-Sun Sy, David M Lee, Ling Xiu Zhang

PLoS One· October 2015

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A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells.
Liheng Yang, Yan Zhang, Lipeng Hu, Ying Zhu, Man-Sun Sy

Virol Sin· August 2014

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Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).
Chae Kim, Tracy Haldiman, Krystyna Surewicz, Yvonne Cohen, Wei Chen, Man-Sun Sy

PLoS Pathog· December 2012

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Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository.
Man-Sun Sy, Sean F Altekruse, Chaoyang Li, Charles F Lynch, Marc T Goodman

Cancer Biomark· November 2012

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Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.
Chae Kim, Tracy Haldiman, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy

PLoS Pathog· September 2011

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A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and nonfibrillar structures.
Kang R Cho, Yu Huang, Shuiliang Yu, Shaoman Yin, Marco Plomp, Man-Sun Sy

J Am Chem Soc· June 2011

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Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.
Chaoyang Li, Shuiliang Yu, Fumihiko Nakamura, Olli T Pentikäinen, Neena Singh, Man-Sun Sy

J Biol Chem· September 2010

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Role of the highly conserved middle region of prion protein (PrP) in PrP-lipid interaction.
Fei Wang, Shaoman Yin, Xinhe Wang, Liang Zha, Man-Sun Sy

Biochemistry· September 2010

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