Publications by authors named "Mandy Yim"

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Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette exchange system.
Domingos Ng, Meixia Zhou, Dejin Zhan, Shirley Yip, Peggy Ko, Mandy Yim

Biotechnol Prog· July 2021

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Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost-effective method for expression of complex molecules.
Emily Dong, Cynthia Lam, Danming Tang, Salina Louie, Mandy Yim

Biotechnol J· April 2021

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Comparison of central corneal thickness measurement by scanning slit topography, infrared, and ultrasound pachymetry in normal and post-LASIK eyes.
Wing-Cheung Ho, Philip Tsze-Ho Lam, Thomas Yee-Hang Chiu, Mandy Ching-Man Yim, Fion Tung-Ching Lau

Int Ophthalmol· November 2020

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Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position.
Joe Carver, Domingos Ng, Michelle Zhou, Peggy Ko, Dejin Zhan, Mandy Yim

Biotechnol Prog· July 2020

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Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum-free media.
Salina Louie, Amy Heidersbach, Noelia Blanco, Benjamin Haley, Christopher M Rose, Mandy Yim

Biotechnol Prog· May 2020

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Achieving greater efficiency and higher confidence in single-cell cloning by combining cell printing and plate imaging technologies.
Mandy Yim, David Shaw

Biotechnol Prog· November 2018

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Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally-derived or not.
Yizhou Zhou, David Shaw, Cynthia Lam, Joni Tsukuda, Mandy Yim

Biotechnol Prog· May 2018

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Development and characterization of an automated imaging workflow to generate clonally-derived cell lines for therapeutic proteins.
David Shaw, Mandy Yim, Joni Tsukuda, John C Joly, Andy Lin

Biotechnol Prog· May 2018

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Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality.
Peggy Ko, Shahram Misaghi, Zhilan Hu, Dejin Zhan, Joni Tsukuda, Mandy Yim

Biotechnol Prog· May 2018

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Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System.
Danming Tang, Cynthia Lam, Salina Louie, Kam Hon Hoi, David Shaw, Mandy Yim

Biotechnol J· January 2018

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Noninvasive Tracking of Encapsulated Insulin Producing Cells Labelled with Magnetic Microspheres by Magnetic Resonance Imaging.
Vijayaganapathy Vaithilingam, Mandy M W Yim, Jayne L Foster, Timothy Stait-Gardner, Jose Oberholzer

J Diabetes Res· June 2017

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Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.
Zhilan Hu, Danming Tang, Shahram Misaghi, Guoying Jiang, Christopher Yu, Mandy Yim

Biotechnol Prog· May 2017

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FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.
Salina Louie, Benjamin Haley, Brett Marshall, Amy Heidersbach, Mandy Yim

Biotechnol Bioeng· March 2017

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Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells.
Cynthia Lam, Lydia Santell, Blair Wilson, Mandy Yim, Salina Louie

Biotechnol Prog· March 2017

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