Publications by authors named "Manfred Jung"

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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.
Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P Simon, Victoria J Butler, Manfred Jung, Julie Andersen, Aimee W Kao, Eric Verdin

October 2019

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Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD co-factor binding.
Ricky Wirawan, Matthias Frei, Anna Heider, Niklas Papenkordt, Florian Friedrich, Manfred Jung

RSC Med Chem· November 2025

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Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages.
Roberto Gimmelli, Giuliana Papoff, Emanuele Fabbrizi, Michela Guida, Cristiana Lalli, Manfred Jung

ACS Infect Dis· November 2025

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From Pharmacophore to Warhead: NAD-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.
Florian Friedrich, Marat Meleshin, Niklas Papenkordt, Lena Gaitzsch, Isabel Prucker, Manfred Jung

Angew Chem Int Ed Engl· October 2025

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The bioactivity of atraric acid as an inducer of cellular senescence in prostate cancer cells is retained by lipophilic derivatives.
Adina Asara Baniahmad, Golnaz Atri Roozbahani, Manfred Jung, Aria Baniahmad

Naunyn Schmiedebergs Arch Pharmacol· September 2025

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Sensitization of Non-M3 Acute Myeloid Leukemia Blasts to All-Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study.
Michael Kruszewski, Claudia Schmoor, Tobias Berg, Usama-Ur Rehman, Marcus Schittenhelm, Johannes Jung, Manfred Jung

Eur J Haematol· September 2025

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Structure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity.
Sheng Wang, Nicolas P F Barthes, Sylvia Urban, Viktor I Hazai, Sebastian O Klein, Manfred Jung

J Med Chem· July 2025

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Molecular determinants for recognition of serotonylated chromatin.
Laura Pulido-Cortés, Hajo Gielingh, Vito Thijssen, Minglong Liu, Ryoji Yoshisada, Manfred Jung

Nucleic Acids Res· July 2025

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Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions.
Florian Friedrich, Matthias Schiedel, Sören Swyter, Lin Zhang, Wolfgang Sippl, Manfred Jung

J Med Chem· June 2025

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Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis.
Marco Kuge, Michael Keppler, Florian Friedrich, Raspudin Saleem-Batcha, Juliana Winter, Manfred Jung

Chembiochem· February 2025

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A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor.
Mariia Zmyslia, Michael J Capper, Michael Grimmeisen, Kerstin Sartory, Benedikt Deuringer, Manfred Jung

RSC Chem Biol· November 2024

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Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors.
Anne Baumann, Niklas Papenkordt, Dina Robaa, Peter D Szigetvari, Anja Vogelmann, Manfred Jung

ACS Chem Neurosci· November 2024

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Soft drug inhibitors for the epigenetic targets lysine-specific demethylase 1 and histone deacetylases.
Johannes Seitz, Marina Auth, Tony Prinz, Mirjam Hau, Pavlos Tzortzoglou, Manfred Jung

Arch Pharm (Weinheim)· October 2024

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Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD-Dependent Lysine Deacylase Sirtuin 2.
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Manfred Jung

J Med Chem· June 2024

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Potent hydroxamate-derived compounds arrest endodyogeny of Toxoplasma gondii tachyzoites.
Carlla Assis Araujo-Silva, Katharina Vögerl, Ferdinand Breu, Manfred Jung, Andreia Luiza Oliveira Costa

Exp Parasitol· April 2024

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Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Manfred Jung

J Med Chem· April 2024

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Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.
Mohamed Abdelsalam, Mariia Zmyslia, Karin Schmidtkunz, Anita Vecchio, Sebastian Hilscher, Manfred Jung

Arch Pharm (Weinheim)· February 2024

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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition.
Vladimir Ćurčić, Mateusz Olszewski, Natalia Maciejewska, Aleksandar Višnjevac, Tatjana Srdić-Rajić, Manfred Jung

Arch Pharm (Weinheim)· February 2024

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Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Sheng Wang, Sebastian O Klein, Sylvia Urban, Maximilian Staudt, Nicolas P F Barthes, Manfred Jung

Nat Commun· January 2024

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Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A Tararina, Emilia Neuwirt, Manfred Jung

J Med Chem· November 2023

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Melatonin-vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat.
Youssef Y Helmi, Niklas Papenkordt, Georg Rennar, Florence Gbahou, Ahmed K El-Hady, Manfred Jung

Arch Pharm (Weinheim)· September 2023

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Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161.
Michael Kohr, Niklas Papenkordt, Manfred Jung, Uli Kazmaier

Org Biomol Chem· May 2023

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Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines.
Matthes Zessin, Marat Meleshin, Sebastian Hilscher, Cordelia Schiene-Fischer, Cyril Barinka, Manfred Jung

Int J Mol Sci· April 2023

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A novel pan-selective bromodomain inhibitor for epigenetic drug design.
Robin Warstat, Mehrosh Pervaiz, Pierre Regenass, Marius Amann, Karin Schmidtkunz, Manfred Jung

Eur J Med Chem· March 2023

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Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics.
Sebastian O Klein, Adina A Baniahmad, Manfred Jung

Chem Commun (Camb)· February 2023

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Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras.
Salma Darwish, Tino Heimburg, Johannes Ridinger, Daniel Herp, Matthias Schmidt, Manfred Jung

Methods Mol Biol· October 2022

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