PubHawk
October 2019 PMID 31602311

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.

Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P Simon, Victoria J Butler, Manfred Jung, Julie Andersen, Aimee W Kao, Eric Verdin

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Mentions

26
Peak: 7 in Oct 2019
across 5 sources since Jul 2019

Extended reach

249,239
potential audience

Total likes

683

Video views

22,677

Mentions per month

Jul 2019 – Dec 2021

Where it's discussed

  • X / Twitter19 posts
  • Facebook2 posts
  • Reddit2 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions reflect a generally positive stance on the significance of the research, with mentions of the compound NDGA as a 'lifespan-increasing drug', and phrases like 'provides mechanistic insight' indicating curiosity about the scientific details. The tone emphasizes promise and curiosity, rather than skepticism or outcry, demonstrating moderate engagement and perceived impact.

AgreementModerate agreement

Most discussions agree that the research offers promising insights into longevity, highlighting NDGA’s role in inhibiting p300 and promoting autophagy.

InterestModerate interest

Participants show moderate interest, frequently mentioning the potential implications for aging and longevity without deep dives into mechanisms.

EngagementModerate engagement

Posts engage with the topic by referencing specific targets like p300 and autophagy, indicating some level of thoughtful discussion, but few elaborate extensively.

ImpactModerate impact

The overall tone suggests the findings are seen as potentially impactful within aging research, though it's early in the scientific process with no claims of immediate applications.

Abstract in brief

  • Aging leads to a decline in physiological functions across all organisms, but environmental factors like diet can influence this process.
  • The compound nordihydroguaiaretic acid (NDGA) has been shown to increase lifespan in both flies and mice, although its exact mechanism of action is not well understood.
  • Research reveals that NDGA inhibits the p300 epigenetic regulator, blocking its acetyltransferase activity and promoting autophagy, which helps explain how NDGA may contribute to increased longevity.
Read the full abstract

Top posts

Most liked on X and Bluesky
MyAgeGroup
@MyAgeGroup · X

'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB. https://t.co/PdKyGjietQ

Nov 2, 2019 · 5 likes · 6 shares · 1,550 followers View post →
npj Journals
@Nature_NPJ · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy #npjAMD https://t.co/qddKyVCVr5 https://t.co/d3Sv2LRSXK

Oct 9, 2019 · 1 like · 9,058 followers View post →
npj Journals
@Nature_NPJ · X

New research from @BuckInstitute shows that lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates #autophagy: https://t.co/vYafMMllVn #agingresearch

Oct 18, 2019 · 1 like · 9,058 followers View post →
bioRxiv
@biorxivpreprint · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy https://t.co/92jYDij1u7 #bioRxiv

Jul 30, 2019 · 137,019 followers View post →
Ken Gusler
@kgusler · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy - https://t.co/kxnuQTaLnB

Oct 18, 2019 · 20,034 followers View post →
npj Journals
@Nature_NPJ · X

New research from @BuckInstitute shows that lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates #autophagy: https://t.co/vYafMMllVn. #agingresearch

Oct 18, 2019 · 9,058 followers View post →

All mentions

bioRxiv Published
@biorxiv_pubd · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy published as: https://t.co/bEMz487EgE #npj_Aging_and_Mechanisms_of_Disease #biorxiv

Dec 30, 2021 · 2,905 followers View post →
bioMioSoftware
@bioMioSoftware · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Aug 26, 2020 · 6 shares · 102 followers View post →
npj Journals
@Nature_NPJ · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. #npjAMD https://t.co/ppJyx8UOac

Aug 23, 2020 · 9,058 followers View post →
annibal_ms
@AnnibalMs · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Nov 3, 2019 · 6 shares · 304 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Nov 2, 2019 · 6 shares · 1,007 followers View post →
A 2.0
@A_2_0_London · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Nov 2, 2019 · 6 shares · 384 followers View post →
Collin Ewald
@CollinEwald · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Nov 2, 2019 · 6 shares · 4,536 followers View post →
Bérénice A. Benayoun, PhD
@BBParis1984 · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Nov 2, 2019 · 6 shares · 3,421 followers View post →
Martin Denzel
@MartinD79 · X

RT @MyAgeGroup: 'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB…

Nov 2, 2019 · 6 shares · 2,911 followers View post →
MyAgeGroup
@MyAgeGroup · X

'Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy' from the lab of @EricVerdin BB. https://t.co/PdKyGjietQ

Nov 2, 2019 · 5 likes · 6 shares · 1,550 followers View post →
UCSF MAC
@UCSFmac · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. These findings identify p300 as a target of NDGA and provide mechanistic insight into its role in longevity. https://t.co/KziMg8odKl @EricVerdin https://t.co/MpcwVliG4s

Oct 24, 2019 · 6,163 followers View post →
Pooja
@pm_girl · X

#Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy https://t.co/1cdVBhwKBy #science

Oct 19, 2019 · 2,069 followers View post →
Ken Gusler
@kgusler · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy - https://t.co/kxnuQTaLnB

Oct 18, 2019 · 20,034 followers View post →
New Scientist Zone
@NewScientistZon · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy https://t.co/hrIGwjhTZL

Oct 18, 2019 · 178 followers View post →
npj Journals
@Nature_NPJ · X

New research from @BuckInstitute shows that lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates #autophagy: https://t.co/vYafMMllVn #agingresearch

Oct 18, 2019 · 1 like · 9,058 followers View post →
npj Journals
@Nature_NPJ · X

New research from @BuckInstitute shows that lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates #autophagy: https://t.co/vYafMMllVn. #agingresearch

Oct 18, 2019 · 9,058 followers View post →
npj Journals
@Nature_NPJ · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy #npjAMD https://t.co/qddKyVCVr5 https://t.co/d3Sv2LRSXK

Oct 9, 2019 · 1 like · 9,058 followers View post →
bioRxiv Cell Biology
@biorxiv_cellbio · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy https://t.co/yyEjmSkRUP #biorxiv_cellbio

Jul 30, 2019 · 7,651 followers View post →
bioRxiv
@biorxivpreprint · X

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy https://t.co/92jYDij1u7 #bioRxiv

Jul 30, 2019 · 137,019 followers View post →