Publications by authors named "Manjula Ramu"

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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.
Erin Skeens, Federica Maschietto, Ramu Manjula, Shanelle Shillingford, James Murphy

Nat Commun· July 2025

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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.
Erin Skeens, Federica Maschietto, Ramu Manjula, Shanelle Shillingford, Elias J Lolis

bioRxiv· September 2024

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A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus.
Jia Li, Lin Leng, Georgios Pantouris, Ramu Manjula, Marta Piecychna

J Biol Chem· July 2024

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Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Joshua Bloom, Georgios Pantouris, Mingzhu He, Bayan Aljabari, Lopa Mishra, Ramu Manjula

Mol Med· March 2024

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Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.
Lukas Spiller, Ramu Manjula, Franz Leissing, Jerome Basquin, Priscila Bourilhon

Sci Signal· November 2023

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A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.
Erin Skeens, Georgios Pantouris, Dilip Shah, Ramu Manjula, Michael J Ombrello

Front Mol Biosci· February 2022

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A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
Emily Chen, Krystle Reiss, Dilip Shah, Ramu Manjula, Brandon Allen

J Biol Chem· September 2021

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SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.
Ramu Manjula, Kumari Anuja, Francisco J Alcain

Front Pharmacol· January 2021

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Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Ramu Manjula, Nikhila Gokhale, Sruthi Unni, Prashant Deshmukh, Rajkumar Reddyrajula

Bioorg Chem· November 2019

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Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.
Ramu Manjula, Sruthi Unni, Gareth S A Wright, Srinivas Bharath M M, Balasundaram Padmanabhan

J Biomol Struct Dyn· September 2019

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Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation.
Ramu Manjula, Gareth S A Wright, Richard W Strange, Balasundaram Padmanabhan

FEBS Lett· May 2018

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Identification of New Inhibitors for Human SIRT1: An in-silico Approach.
Balasundaram Padmanabhan, Manjula Ramu, Shruti Mathur, Sruthi Unni, Saravanamuthu Thiyagarajan

Med Chem· July 2017

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A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex.
Shailesh Tripathi, Shruti Mathur, Prashant Deshmukh, Ramu Manjula, Balasundaram Padmanabhan

PLoS One· July 2017

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Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.
Balasundaram Padmanabhan, Shruti Mathur, Ramu Manjula, Shailesh Tripathi

J Biosci· June 2016

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A compendium of molecules involved in vector-pathogen interactions pertaining to malaria.
Sreelakshmi K Sreenivasamurthy, Gourav Dey, Manjula Ramu, Manish Kumar, Manoj K Gupta

Malar J· June 2013

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