Publications by authors named "Manoj Ramjee"

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Selective Phenylimidazole-Based Inhibitors of the Proteasome.
Wenhu Zhan, Hao-Chi Hsu, Trevor Morgan, Tierra Ouellette, Kristin Burns-Huang, Manoj Ramjee

J Med Chem· October 2019

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Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
Shishir M Pant, Amanda Mukonoweshuro, Bimbisar Desai, Manoj K Ramjee, Christopher N Selway

J Med Chem· May 2018

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Continuous-flow injection microfluidic thrombin assays: The effect of binding kinetics on observed enzyme inhibition.
Manoj K Ramjee, Sital Patel

Anal Biochem· July 2017

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The background, discovery and clinical development of BCR-ABL inhibitors.
Gemma K Lambert, Anne-Kathrin Duhme-Klair, Trevor Morgan, Manoj K Ramjee

Drug Discov Today· October 2013

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Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery.
Werngard Czechtizky, Jüergen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Manoj K Ramjee

ACS Med Chem Lett· August 2013

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Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.
Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng, Karl R Gibson, Manoj K Ramjee

J Med Chem· April 2013

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Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery.
Manoj K Ramjee, Nicholas S Flinn, Tracy P Pemberton, Martin Quibell, Yikang Wang

Biochem J· October 2006

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A single-step method for the production of sugar hydrazides: intermediates for the chemoselective preparation of glycoconjugates.
Nicholas S Flinn, Martin Quibell, Tracy P Monk, Manoj K Ramjee, Christopher J Urch

Bioconjug Chem· September 2005

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cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition.
Yikang Wang, Alex Benn, Nick Flinn, Tracy Monk, Manoj Ramjee

Bioorg Med Chem Lett· March 2005

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Novel chemoselective linkage chemistry toward controlled loading of ligands to proteins through in situ real-time quantification of conjugate formation.
Nicholas S Flinn, Martin Quibell, William G Turnell, Tracy P Monk, Manoj K Ramjee

Bioconjug Chem· February 2005

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Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases.
Martin Quibell, Alex Benn, Nick Flinn, Tracy Monk, Manoj Ramjee

Bioorg Med Chem· February 2005

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Bicyclic peptidomimetic tetrahydrofuro[3,2-b]pyrrol-3-one and hexahydrofuro[3,2-b]pyridine-3-one based scaffolds: synthesis and cysteinyl proteinase inhibition.
Martin Quibell, Alex Benn, Nick Flinn, Tracy Monk, Manoj Ramjee

Bioorg Med Chem· November 2004

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Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[b]furan-3a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition.
John Watts, Alex Benn, Nick Flinn, Tracy Monk, Manoj Ramjee

Bioorg Med Chem· June 2004

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