Publications by authors named "Manon A A Jansen"

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Profiling a Neo-Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study of the KLH Challenge Model.
Micha N Ronner, Hendrika W Grievink, Mahdi Saghari, Michelle Osse, Thierry P P van den Bosch, Manon A A Jansen

Clin Pharmacol Ther· November 2025

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Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Manon Aleida Adriana Jansen

Clin Pharmacol Ther· November 2025

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Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience.
Juliette A van den Noort, Marella C E van Ruissen, Lisanne C A Smidt, Naomi B Klarenbeek, Philip H K Kremer, Manon A A Jansen

Br J Clin Pharmacol· September 2025

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A systematic review of pharmaceutical targets in the mucosal immune system for treatment of non-intestinal auto-immune diseases.
Boukje C Eveleens Maarse, Amber D Hofstede, Manon A A Jansen, Matthijs Moerland

Biomed Pharmacother· July 2025

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Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development.
Juliette A van den Noort, Salma Assil, Micha N Ronner, Michelle Osse, Iris Pot, Manon A A Jansen

Inflammation· June 2025

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A suction blister model to characterize epidermal wound healing and evaluate the efficacy of the topical wound healing agent INM-755 in healthy volunteers.
Wouter Ten Voorde, Selinde Wind, Ismahaan Abdisalaam, Alexandra Mancini, Feeke Linders, Manon A A Jansen

Eur J Pharm Sci· January 2025

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Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses - a randomized, placebo-controlled clinical trial.
Boukje C Eveleens Maarse, Micha N Ronner, Manon A A Jansen, Tessa Niemeyer-van der Kolk, Aliede E In 't Veld

Immunol Res· August 2024

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The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers.
Stefan J Jodl, Wouter Ten Voorde, Stefan Klein, Andrea Wagenfeld, Frank S Zollmann, Manon A A Jansen

Clin Transl Sci· March 2024

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Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.
Aliede E In 't Veld, Hendrika W Grievink, Johan L van der Plas, Boukje C Eveleens Maarse, Sebastiaan J W van Kraaij, Manon A A Jansen

Immunol Res· August 2023

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Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model.
Salma Assil, Thomas P Buters, Pieter W Hameeteman, Charlie Hallard, Nicoline Treijtel, Manon A A Jansen

Front Immunol· August 2023

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Immune Monitoring of Mycophenolate Mofetil Activity in Healthy Volunteers Using T Cell Function Assays.
Aliede E In 't Veld, Manon A A Jansen, Marieke L de Kam, Yalҫin Yavuz, Dirk Jan A R Moes

Pharmaceutics· May 2023

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Correction: Wind et al. Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial. 2022, , 1510.
Selinde S Wind, Manon A A Jansen, Melanie Rijsbergen, Michiel J van Esdonk, Dimitrios Ziagkos

Cancers (Basel)· February 2023

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Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics.
Aliede E In 't Veld, Manon A A Jansen, Bertine W Huisman, Mascha Schoonakker, Marieke L de Kam

Pharmaceutics· September 2022

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Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers.
Thomas P Buters, Pieter W Hameeteman, Iris M E Jansen, Floris C van Hindevoort, Wouter Ten Voorde, Manon A A Jansen

Clin Pharmacol Ther· April 2022

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Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial.
Boukje C Eveleens Maarse, Claus Graff, Jørgen K Kanters, Michiel J van Esdonk, Michiel J B Kemme, Manon A A Jansen

Br J Clin Pharmacol· March 2022

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Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial.
Selinde S Wind, Manon A A Jansen, Melanie Rijsbergen, Michiel J van Esdonk, Dimitrios Ziagkos

Cancers (Basel)· March 2022

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.
Thomas P Buters, Pieter W Hameeteman, Iris M E Jansen, Floris C van Hindevoort, Wouter Ten Voorde, Manon A A Jansen

Br J Clin Pharmacol· February 2022

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Erratum to "Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19".
Aliede E In 't Veld, Manon A A Jansen, Luuk C A Ciere, Matthijs Moerland

J Immunol Res· May 2021

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Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19.
Aliede E In 't Veld, Manon A A Jansen, Luuk C A Ciere, Matthijs Moerland

J Immunol Res· April 2021

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Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4 T Cells in a Murine Arthritis Model.
Manon A A Jansen, Rachel Spiering, Irene S Ludwig, Willem van Eden, Catharien M U Hilkens

Front Immunol· October 2020

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Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis.
Willem van Eden, Manon A A Jansen, Irene S Ludwig, Paul Leufkens, Marlies C van der Goes

Front Immunol· September 2020

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Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.
Rachel Spiering, Manon A A Jansen, Matthew J Wood, Anshorulloh A Fath, Oliver Eltherington

J Transl Med· November 2019

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Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model.
Manon A A Jansen, Lasse H Klausen, Kaushik Thanki, Jeppe Lyngsø, Jan Skov Pedersen

Eur J Pharm Biopharm· September 2019

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Routing dependent immune responses after experimental R848-adjuvated vaccination.
Susan van Aalst, Manon A A Jansen, Irene S Ludwig, Ruurd van der Zee, Willem van Eden

Vaccine· March 2018

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The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins.
Willem van Eden, Manon A A Jansen, A Charlotte Mt de Wolf, Irene S Ludwig, Paul Leufkens

Front Immunol· November 2017

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