Publications by authors named "Manuel Chan"

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Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.
Ahmed Mamai, Mohammed M Morshed, Michael Prakesch, Gennady Poda, Pandiaraju Subramanian, Manuel Chan

Bioorg Med Chem Lett· February 2026

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OICR-41103 as a chemical probe for the DCAF1 WD40 domain.
Serah W Kimani, Mahmoud Noureldin, Brian Wilson, Laurent Hoffer, Stuart R Green, Manuel Chan

Commun Biol· July 2025

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Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Mark F Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W Kimani, Ahmed Mamai, Manuel Chan

Nat Commun· November 2024

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Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.
Ahmed Mamai, Anh M Chau, Brian J Wilson, Iain D Watson, Babu B Joseph, Manuel Chan

ACS Med Chem Lett· February 2023

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Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.
Punit Saraon, Jamie Snider, Wiebke Schormann, Ankit Rai, Nikolina Radulovich, Manuel Chan

J Mol Biol· November 2021

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Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.
Manuel Chan, Michel Gravel, Alexandre Bramoullé, Gaëlle Bridon, Daina Avizonis

Cancer Res· November 2014

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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Bernard Côté, Jason D Burch, Ernest Asante-Appiah, Chris Bayly, Leanne Bédard, Manuel Chan

Bioorg Med Chem Lett· February 2014

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Oxygen limitation favors the production of protein with antimicrobial activity in Pseudoalteromonas sp.
Ruth López, Víctor Monteón, Ernesto Chan, Rubí Montejo, Manuel Chan

Braz J Microbiol· July 2012

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Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.
Shilan Liu, Yinhui Liu, Hongmei Wang, Yili Ding, Hao Wu, Manuel Chan

Bioorg Med Chem Lett· October 2009

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Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Pamela Tran, Daniel Leclerc, Manuel Chan, Aditya Pai, Francois Hiou-Tim

Mamm Genome· September 2002

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