Publications by authors named "Manuel D Gahete"

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miR-191-5p: A tumour suppressor miRNA and a personalized biomarker and potential therapeutic tool connecting prostate cancer and obesity.
Francisco Porcel-Pastrana, Antonio J Montero-Hidalgo, Vicente Herrero-Aguayo, Prudencio Sáez-Martínez, Jesús M Perez-Gómez, Manuel D Gahete

Biomed Pharmacother· August 2025

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MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling.
Marta Torrecilla-Parra, Virginia Pardo-Marqués, Antonio C Fuentes-Fayos, Miguel E G-García, Mario Fernández-de Frutos, Manuel D Gahete

J Exp Clin Cancer Res· August 2025

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Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets.
Antonio C Fuentes-Fayos, Miguel E G-García, Teresa Sánchez-Medianero, John Apps, Álvaro Flores-Martínez, Manuel D Gahete

Acta Neuropathol Commun· June 2025

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From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections.
André Sarmento-Cabral, Antonio C Fuentes-Fayos, Fernando Mata Ordoñez, Antonio J León-González, Antonio J Martínez-Fuentes, Manuel D Gahete

Rev Endocr Metab Disord· April 2025

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Assessing the diagnostic, prognostic, and therapeutic potential of the somatostatin/cortistatin system in glioblastoma.
Miguel E G-García, Ana S De la Rosa-Herencia, Álvaro Flores-Martínez, María Ortega-Bellido, Rafael Sánchez-Sánchez, Manuel D Gahete

Cell Mol Life Sci· April 2025

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Cellular and Molecular Evidence of the Synergistic Antitumour Effects of Hydroxytyrosol and Metformin in Prostate Cancer.
Francisco Porcel-Pastrana, Antonio J Montero-Hidalgo, Miguel E G-García, Ignacio Gil-Duque, Antonio Prats-Escribano, Manuel D Gahete

Int J Mol Sci· February 2025

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Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.
Natalia Hermán-Sánchez, Mercedes Del Rio-Moreno, Rubén Ciria, Marina E Sánchez-Frias, Maite G Fernández-Barrena, Manuel D Gahete

Mol Cancer· January 2025

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Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH).
Edilmar Alvarado-Tapias, Douglas Maya-Miles, Agustin Albillos, Rocio Aller, Javier Ampuero, Manuel D Gahete

Gastroenterol Hepatol· December 2024

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The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer.
Natalia Hermán-Sánchez, Miguel E G-García, Juan M Jiménez-Vacas, Elena M Yubero-Serrano, Laura M López-Sánchez, Manuel D Gahete

Cell Mol Life Sci· December 2024

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Clinical value of circulating splicing factors in prostate cancer: SRRM1 as a novel predictive biomarker and therapeutic target.
Antonio J Montero-Hidalgo, Enrique Gómez-Gómez, Manuel Galán-Cañete, Francisco Porcel-Pastrana, Jesús M Pérez-Gómez, Manuel D Gahete

Mol Ther Oncol· December 2024

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The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in pancreatic ductal adenocarcinoma.
Ricardo Blázquez-Encinas, Emilia Alors-Pérez, María Trinidad Moreno-Montilla, Víctor García-Vioque, Marina Esther Sánchez-Frías, Manuel D Gahete

Cancer Gene Ther· November 2024

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Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets.
Emilia Alors-Pérez, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Juan Manuel Jiménez-Vacas, Manuel D Gahete

Mol Oncol· October 2024

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SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer.
Antonio J Montero-Hidalgo, Juan M Jiménez-Vacas, Enrique Gómez-Gómez, Francisco Porcel-Pastrana, Prudencio Sáez-Martínez, Manuel D Gahete

Sci Adv· October 2024

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Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis.
Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Manuel D Gahete

Aging Dis· October 2024

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Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response.
Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, Víctor García-Vioque, Antonio Agraz-Doblas, Manuel D Gahete

Mol Ther Nucleic Acids· March 2024

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Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1.
Prudencio Sáez-Martínez, Francisco Porcel-Pastrana, Antonio J Montero-Hidalgo, Samanta Lozano de la Haba, Rafael Sanchez-Sanchez, Manuel D Gahete

Cancer Lett· March 2024

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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
Sofia Lachiondo-Ortega, Claudia M Rejano-Gordillo, Jorge Simon, Fernando Lopitz-Otsoa, Teresa C Delgado, Manuel D Gahete

Cell Rep· March 2024

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Does Telotristat Have a Role in Preventing Carcinoid Heart Disease?
Aura D Herrera-Martínez, Antonio C Fuentes-Fayos, Rafael Sanchez-Sanchez, Antonio J Montero, André Sarmento-Cabral, Manuel D Gahete

Int J Mol Sci· February 2024

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Exploring the role of the inflammasomes on prostate cancer: Interplay with obesity.
Jesús M Pérez-Gómez, Antonio J Montero-Hidalgo, Antonio C Fuentes-Fayos, André Sarmento-Cabral, Rocio Guzmán-Ruiz, Manuel D Gahete

Rev Endocr Metab Disord· December 2023

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Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment.
Aura D Herrera-Martínez, Laura L S Castillo-Peinado, María J Molina-Puerta, Alfonso Calañas-Continente, Antonio Membrives, Manuel D Gahete

Front Endocrinol (Lausanne)· November 2023

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LRP10, PGK1 and RPLP0: Best Reference Genes in Periprostatic Adipose Tissue under Obesity and Prostate Cancer Conditions.
Jesús M Pérez-Gómez, Francisco Porcel-Pastrana, Marina De La Luz-Borrero, Antonio J Montero-Hidalgo, Enrique Gómez-Gómez, Manuel D Gahete

Int J Mol Sci· October 2023

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Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
Antonio C Fuentes-Fayos, Miguel E G-García, Jesús M Pérez-Gómez, Antonio J Montero-Hidalgo, Julia Martín-Colom, Manuel D Gahete

EBioMedicine· April 2023

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PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.
Juan L López-Cánovas, Natalia Hermán-Sánchez, Mercedes Del Rio-Moreno, Antonio C Fuentes-Fayos, Araceli Lara-López, Manuel D Gahete

Exp Mol Med· January 2023

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Inflammasomes: Cause or consequence of obesity-associated comorbidities in humans.
Aura D Herrera-Martínez, Vicente Herrero-Aguayo, Jesús M Pérez-Gómez, Manuel D Gahete, Raúl M Luque

Obesity (Silver Spring)· December 2022

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Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing.
Juan L López-Cánovas, Natalia Hermán-Sánchez, Maria Trinidad Moreno-Montilla, Mercedes Del Rio-Moreno, Emilia Alors-Perez, Manuel D Gahete

Clin Transl Med· November 2022

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