Publications by authors named "Manuel Modolell"

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Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Janny A Villa-Pulgarín, Consuelo Gajate, Javier Botet, Alberto Jimenez, Nicole Justies, Manuel Modolell

PLoS Negl Trop Dis· August 2017

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Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites.
Fitsumbrhan Tajebe, Mulusew Getahun, Emebet Adem, Asrat Hailu, Mulualem Lemma, Manuel Modolell

PLoS Negl Trop Dis· July 2017

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Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions.
Endalew Yizengaw, Mulusew Getahun, Fitsumbrhan Tajebe, Edward Cruz Cervera, Emebet Adem, Manuel Modolell

Front Immunol· November 2016

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Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production.
Emebet Adem, Fitsumbirhan Tajebe, Mulusew Getahun, Amare Kiflie, Ermias Diro, Manuel Modolell

PLoS Negl Trop Dis· March 2016

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Protein energy malnutrition increases arginase activity in monocytes and macrophages.
Karina Corware, Vanessa Yardley, Christopher Mack, Steffen Schuster, Hafid Al-Hassi, Manuel Modolell

Nutr Metab (Lond)· November 2014

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Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.
Tom Cloke, Markus Munder, Philip Bergin, Shanthi Herath, Manuel Modolell

PLoS One· June 2014

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Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia.
Tamrat Abebe, Yegnasew Takele, Teklu Weldegebreal, Tom Cloke, Ellen Closs, Manuel Modolell

PLoS Negl Trop Dis· August 2013

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Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection.
Yegnasew Takele, Tamrat Abebe, Teklu Weldegebreal, Asrat Hailu, Workagegnehu Hailu, Manuel Modolell

PLoS Negl Trop Dis· June 2013

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Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of Slc7a2 (CAT2), and susceptibility to Leishmania infection is reduced.
M Gloria Sans-Fons, Andrée Yeramian, Selma Pereira-Lopes, Luis F Santamaría-Babi, Manuel Modolell

J Infect Dis· June 2013

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Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.
Tamrat Abebe, Asrat Hailu, Mihretu Woldeyes, Woinshet Mekonen, Kassahun Bilcha, Manuel Modolell

PLoS Negl Trop Dis· September 2012

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In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.
Rubén E Varela-M, Janny A Villa-Pulgarin, Edward Yepes, Ingrid Müller, Manuel Modolell

PLoS Negl Trop Dis· August 2012

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Arginine and macrophage activation.
Mònica Comalada, Andree Yeramian, Manuel Modolell, Jorge Lloberas, Antonio Celada

Methods Mol Biol· May 2012

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Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.
Manuel Modolell, Beak-San Choi, Robert O Ryan, Maggie Hancock, Richard G Titus

PLoS Negl Trop Dis· July 2009

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Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.
Faustino Mollinedo, Consuelo Gajate, Ana I Morales, Esther del Canto-Jañez, Nicole Justies, Manuel Modolell

J Pharmacol Exp Ther· May 2009

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Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.
Jennifer M Fitzpatrick, Jose M Fuentes, Iain W Chalmers, Thomas A Wynn, Manuel Modolell

Int J Parasitol· February 2009

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Age-related alteration of arginase activity impacts on severity of leishmaniasis.
Ingrid Müller, Asrat Hailu, Beak-San Choi, Tamrat Abebe, Jose M Fuentes, Manuel Modolell

PLoS Negl Trop Dis· May 2008

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Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy.
Pascale Kropf, David Baud, Sara E Marshall, Markus Munder, Angelina Mosley, Manuel Modolell

Eur J Immunol· April 2007

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Suppression of T-cell functions by human granulocyte arginase.
Markus Munder, Henriette Schneider, Claudia Luckner, Thomas Giese, Claus-Dieter Langhans, Manuel Modolell

Blood· September 2006

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Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.
Andrée Yeramian, Lorena Martin, Luis Arpa, Joan Bertran, Concepció Soler, Manuel Modolell

Eur J Immunol· June 2006

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Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.
Lorena Martín, Mónica Comalada, Luc Marti, Ellen I Closs, Carol L MacLeod, Manuel Modolell

Am J Physiol Cell Physiol· May 2006

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Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages.
Andrée Yeramian, Lorena Martin, Neus Serrat, Luis Arpa, Concepció Soler, Manuel Modolell

J Immunol· May 2006

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Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?
Praxedis Martin, Reinhard Wallich, Julian Pardo, Arno Müllbacher, Markus Munder, Manuel Modolell

Blood· October 2005

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Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.
Pascale Kropf, José M Fuentes, Eva Fähnrich, Luis Arpa, Shanthi Herath, Manuel Modolell

FASEB J· June 2005

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Arginine metabolism during macrophage autocrine activation and infection with mouse hepatitis virus 3.
Cristiani Moreira, Maria H Tsuhako, Milene Tino de Franco, Manuel Modolell, Carlos A Pereira

Immunobiology· April 2005

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Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.
Markus Munder, Faustino Mollinedo, Jero Calafat, Javier Canchado, Cristina Gil-Lamaignere, Manuel Modolell

Blood· March 2005

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