Publications by authors named "Marc Chikhani"

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Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilot.
Bronwen Connolly, Naomi Dickson, Ashley Agus, Bronagh Blackwood, Mark Borthwick, Marc Chikhani

NIHR Open Res· April 2025

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A computational cardiopulmonary physiology simulator accurately predicts individual patient responses to changes in mechanical ventilator settings.
Sonal Mistry, Bindi S Brook, Sina Saffaran, Marc Chikhani, David M Hannon

Annu Int Conf IEEE Eng Med Biol Soc· July 2022

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Why Reduced Inspiratory Pressure Could Determine Success of Non-Invasive Ventilation in Acute Hypoxic Respiratory Failure.
Liam Weaver, Sina Saffaran, Marc Chikhani, John G Laffey, Tim E Scott

Annu Int Conf IEEE Eng Med Biol Soc· July 2022

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Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study.
Liam Weaver, Anup Das, Sina Saffaran, Nadir Yehya, Marc Chikhani

Br J Anaesth· June 2022

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Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation.
Sonal Mistry, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E Scott, Marc Chikhani

Respir Res· April 2022

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High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study.
Liam Weaver, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E Scott, Marc Chikhani

Ann Intensive Care· July 2021

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Supporting more than one patient with a single mechanical ventilator: useful last resort or unjustifiable risk?
John G Laffey, Marc Chikhani, Declan G Bates, Jonathan G Hardman

Br J Anaesth· September 2020

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Airway clearance techniques and use of mucoactive agents for adult critically ill patients with acute respiratory failure: a qualitative study exploring UK physiotherapy practice.
Bronwen Connolly, Matthew Barclay, Bronagh Blackwood, Judy Bradley, Rohan Anand, Marc Chikhani

Physiotherapy· September 2020

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In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications.
Anup Das, Sina Saffaran, Marc Chikhani, Timothy E Scott, Marianna Laviola

Crit Care Explor· September 2020

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Mucoactive agent use in adult UK Critical Care Units: a survey of health care professionals' perception, pharmacists' description of practice, and point prevalence of mucoactive use in invasively mechanically ventilated patients.
Mark Borthwick, Danny McAuley, John Warburton, Rohan Anand, Judy Bradley, Marc Chikhani

PeerJ· May 2020

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Predicting 30-day mortality in patients with sepsis: An exploratory analysis of process of care and patient characteristics.
Miriam Sanderson, Marc Chikhani, Esme Blyth, Sally Wood, Iain K Moppett

J Intensive Care Soc· November 2018

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Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation.
Marianna Laviola, Anup Das, Marc Chikhani, Declan G Bates, Jonathan G Hardman

Annu Int Conf IEEE Eng Med Biol Soc· July 2017

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Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome.
Anup Das, Mainul Haque, Marc Chikhani, Oana Cole, Wenfei Wang

BMC Pulm Med· February 2017

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Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies.
Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Tayyba Ali

Annu Int Conf IEEE Eng Med Biol Soc· October 2016

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Creating virtual ARDS patients.
Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Jonathan G Hardman

Annu Int Conf IEEE Eng Med Biol Soc· August 2016

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Computational simulation indicates that moderately high-frequency ventilation can allow safe reduction of tidal volumes and airway pressures in ARDS patients.
Wenfei Wang, Anup Das, Oanna Cole, Marc Chikhani, Jonathan G Hardman

Intensive Care Med Exp· December 2015

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Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation.
Anup Das, Oana Cole, Marc Chikhani, Wenfei Wang, Tayyba Ali

Crit Care· January 2015

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Can computer simulators accurately represent the pathophysiology of individual COPD patients?
Wenfei Wang, Anup Das, Tayyba Ali, Oanna Cole, Marc Chikhani

Intensive Care Med Exp· December 2014

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