Publications by authors named "Marc David Ruepp"

Claim this Profile
A
Analysing the effect of full-length and C-terminally truncated progranulin on proliferation, colony formation, and migration in HepG2 and U87 cells.
Alexander M Hofer, Luisa Tobler, Marc-David Ruepp, Oliver Mühlemann

Sci Rep· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis.
Puja R Mehta, Tomas Solomon, Sarah Pickles, Peter Harley, Michela Barioglio, Marc-David Ruepp

bioRxiv· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS.
Jacob Neeves, Marija Petrić Howe, Oliver J Ziff, Beth Callaghan, Daniel Jutzi, Marc-David Ruepp

Sci Adv· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cognition on the move: Examining the role of physical exercise and neurogenesis in counteracting cognitive aging.
Sahand Farmand, Andrea Du Preez, Curie Kim, Chiara de Lucia, Marc-David Ruepp

Ageing Res Rev· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons.
Benedikt V Hölbling, Yashica Gupta, Paolo M Marchi, Magda L Atilano, Michael Flower, Marc-David Ruepp

Cell Rep· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Christoph Schweingruber, Jik Nijssen, Jonas Mechtersheimer, Stefan Reber, Mélanie Lebœuf, Marc-David Ruepp

Nat Commun· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Generation of repeat knock-in iPSC lines for modelling ALS and FTD.
Rachel Coneys, Alexander J Cammack, Remya R Nair, David Thompson, Jonas Mechtersheimer, Marc-David Ruepp

bioRxiv· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes.
Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Marc-David Ruepp

Nucleic Acids Res· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons.
Carole Shum, Erin C Hedges, Joseph Allison, Youn-Bok Lee, Natalia Arias, Marc-David Ruepp

Stem Cell Reports· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions.
Seung Chan Kim, Scott J Mitchell, Seema Qamar, Daniel J Whitcomb, Marc-David Ruepp

Acta Neuropathol Commun· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
P2XR influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
Paula Beltran-Lobo, Martina M Hughes, Claire Troakes, Cara L Croft, Huzefa Rupawala, Marc-David Ruepp

Brain Behav Immun· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot-Marie-Tooth type 2A.
Federica Rizzo, Silvia Bono, Marc David Ruepp, Sabrina Salani, Linda Ottoboni

Cell Mol Life Sci· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.
Sébastien Campagne, Daniel Jutzi, Florian Malard, Maja Matoga, Ksenija Romane, Marc-David Ruepp

Nat Commun· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.
Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Marc-David Ruepp

EMBO J· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Shiden Solomon, Nirmal Kumar Sampathkumar, Ivo Carre, Mrityunjoy Mondal, George Chennell, Marc-David Ruepp

Cell Mol Life Sci· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Alternative Splicing in Human Biology and Disease.
Daniel Jutzi, Marc-David Ruepp

Methods Mol Biol· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.
François Halloy, Pavithra S Iyer, Alice Ghidini, Veronika Lysenko, Jasmin Barman-Aksözen, Marc-David Ruepp

Cell Chem Biol· August 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.
Stefan Reber, Daniel Jutzi, Helen Lindsay, Anny Devoy, Jonas Mechtersheimer, Marc-David Ruepp

Nucleic Acids Res· July 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells.
Ankur Gadgil, Agnieszka Walczak, Agata Stępień, Jonas Mechtersheimer, Agnes Lumi Nishimura, Marc-David Ruepp

Sci Rep· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.
Brunno R Levone, Silvia C Lenzken, Marco Antonaci, Andreas Maiser, Alexander Rapp, Marc-David Ruepp

J Cell Biol· May 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Daniel Jutzi, Sébastien Campagne, Ralf Schmidt, Stefan Reber, Jonas Mechtersheimer, Marc-David Ruepp

Nat Commun· December 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis.
Alessia Loffreda, Monica Nizzardo, Alessandro Arosio, Marc-David Ruepp, Raffaele A Calogero

Prog Neurobiol· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.
Jack Humphrey, Nicol Birsa, Carmelo Milioto, Martha McLaughlin, Agnieszka M Ule, Marc-David Ruepp

Nucleic Acids Res· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Human vtRNA1-1 Levels Modulate Signaling Pathways and Regulate Apoptosis in Human Cancer Cells.
Lisamaria Bracher, Iolanda Ferro, Carlos Pulido-Quetglas, Marc-David Ruepp, Rory Johnson

Biomolecules· April 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Ian Casci, Karthik Krishnamurthy, Sukhleen Kour, Vadreenath Tripathy, Nandini Ramesh, Marc-David Ruepp

Nat Commun· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis