Publications by authors named "Marcus Ruscetti"

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KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression.
Youwei Qiao, Matthew F Yee, Chaitanya N Parikh, Boyang Ma, Yueying Cao, Marcus Ruscetti

Adv Sci (Weinh)· December 2025

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Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression.
Suresh Chava, Suresh Bugide, Parmanand Malvi, Kelly D DeMarco, Boyang Ma, Marcus Ruscetti

EMBO Mol Med· December 2025

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MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-cell and Immunotherapy Responses in Prostate Cancer.
Katherine C Murphy, Kelly D DeMarco, Lin Zhou, Jessica Peura, Hadiya K Giwa, Marcus Ruscetti

Cancer Res· November 2025

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SPARC: A Multipayload ADC Architecture for Programmable Drug Combinations.
Wenlong Sun, Weining Weng, Jing Shi, Boyang Ma, Kelly D DeMarco, Marcus Ruscetti

Bioconjug Chem· October 2025

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P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy.
Lin Zhou, Kelly D DeMarco, Katherine C Murphy, Zhenpeng Wu, Jinping Li, Marcus Ruscetti

Cancer Discov· October 2025

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PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
Shreya R Chowdhury, Chaitanya N Parikh, Arshia N Kaur, Kelly D DeMarco, Hadiya K Giwa, Marcus Ruscetti

Proc Natl Acad Sci U S A· September 2025

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Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose lipogenesis.
Nikita Bhalerao, Yamini Ogoti, Jessica Peura, Calvin Johnson, Qingbo Chen, Marcus Ruscetti

bioRxiv· August 2025

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KRAS withdrawal in Cholangiocarcinoma leads to immune infiltration and tumor regression.
Youwei Qiao, Matthew F Yee, Chaitanya N Parikh, Yueying Cao, Yu-Huan Shih, Marcus Ruscetti

bioRxiv· June 2025

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Mitochondrial Ca controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity.
Jillian S Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Marcus Ruscetti

Cell Rep· May 2025

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Cellular senescence offers distinct immunological vulnerabilities in cancer.
Lin Zhou, Boyang Ma, Marcus Ruscetti

Trends Cancer· April 2025

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Lineage tracing senescence in vivo shows not all senescent cells are created equal.
Marcus Ruscetti

Dev Cell· January 2025

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Parkin activates innate immunity and promotes antitumor immune responses.
Michela Perego, Minjeong Yeon, Ekta Agarwal, Andrew T Milcarek, Irene Bertolini, Marcus Ruscetti

J Clin Invest· January 2025

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Measuring the impact of therapy-induced senescence on NK cell phenotypes in cancer.
Shreya R Chowdhury, Katherine C Murphy, Chaitanya N Parikh, Kelly D DeMarco, Lin Zhou, Marcus Ruscetti

Methods Cell Biol· November 2024

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Mitochondrial Ca controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity.
Jillian S Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Marcus Ruscetti

bioRxiv· August 2024

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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer.
Loretah Chibaya, Kelly D DeMarco, Christina F Lusi, Griffin I Kane, Meghan L Brassil, Marcus Ruscetti

Sci Transl Med· August 2024

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Parkin activates innate immunity and promotes antitumor immune responses.
Michela Perego, Minjeong Yeon, Ekta Agarwal, Andrew T Milcarek, Irene Bertolini, Marcus Ruscetti

J Clin Invest· August 2024

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MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer.
Katherine C Murphy, Kelly D DeMarco, Lin Zhou, Yvette Lopez-Diaz, Yu-Jui Ho, Marcus Ruscetti

bioRxiv· July 2024

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Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering.
Katherine C Murphy, Marcus Ruscetti

Cold Spring Harb Perspect Med· April 2024

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Cancer Hallmarks: Piecing the Puzzle Together.
Maria P Alcolea, Direna Alonso-Curbelo, Chiara Ambrogio, Susan Bullman, Ana Luísa Correia, Marcus Ruscetti

Cancer Discov· April 2024

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Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer.
Loretah Chibaya, Christina F Lusi, Kelly D DeMarco, Griffin I Kane, Meghan L Brassil, Marcus Ruscetti

bioRxiv· September 2023

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Senescent macrophages: A new "old" player in lung cancer development.
Lin Zhou, Marcus Ruscetti

Cancer Cell· July 2023

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EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.
Loretah Chibaya, Katherine C Murphy, Kelly D DeMarco, Sneha Gopalan, Haibo Liu, Marcus Ruscetti

Nat Cancer· June 2023

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Senescence and the tumor-immune landscape: Implications for cancer immunotherapy.
Loretah Chibaya, Jarin Snyder, Marcus Ruscetti

Semin Cancer Biol· November 2022

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Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade.
Arnab Ghosh, Judith Michels, Riccardo Mezzadra, Divya Venkatesh, Lauren Dong, Marcus Ruscetti

J Clin Invest· September 2022

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