Publications by authors named "Marcus Schewe"

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Atomistic mechanism of noncanonical voltage gating in K channels.
Yessenbek K Aldakul, Marcus Schewe, Carlos Coll-Diez, Songhwan Hwang, Thomas Baukrowitz

Sci Adv· August 2025

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Cryo-EM structure of the human THIK-1 K2P K channel reveals a lower Y gate regulated by lipids and anesthetics.
Karin E J Rödström, Bisher Eymsh, Peter Proks, Mehtab S Hayre, Sönke Cordeiro, Marcus Schewe

Nat Struct Mol Biol· July 2025

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Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease.
Peter Rory Hall, Thibault Jouen-Tachoire, Marcus Schewe, Peter Proks, Thomas Baukrowitz

Structure· January 2025

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Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K channel TALK-2.
Lea C Neelsen, Elena B Riel, Susanne Rinné, Freya-Rebecca Schmid, Björn C Jürs, Marcus Schewe

Nat Commun· August 2024

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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Marcus Schewe

Nat Commun· May 2024

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Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels.
Berke Türkaydin, Marcus Schewe, Elena Barbara Riel, Friederike Schulz, Johann Biedermann

Nat Commun· May 2024

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Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation.
Christina B Schroeter, Christopher Nelke, Marcus Schewe, Lucas Spohler, Alexander M Herrmann

Biol Chem· March 2023

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Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.
Janina Sörmann, Marcus Schewe, Peter Proks, Thibault Jouen-Tachoire, Shanlin Rao

Nat Genet· October 2022

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The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism.
Elena B Riel, Björn C Jürs, Sönke Cordeiro, Marianne Musinszki, Marcus Schewe

J Gen Physiol· February 2022

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Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.
Peter Proks, Marcus Schewe, Linus J Conrad, Shanlin Rao, Kristin Rathje

J Gen Physiol· August 2021

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An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
William W Chang, Ann-Sophie Matt, Marcus Schewe, Marianne Musinszki, Sandra Grüssel

Proc Natl Acad Sci U S A· July 2021

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Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K channel.
Ehsan Nematian-Ardestani, Firdaus Abd-Wahab, Franck C Chatelain, Han Sun, Marcus Schewe

J Biol Chem· January 2020

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A pharmacological master key mechanism that unlocks the selectivity filter gate in K channels.
Marcus Schewe, Han Sun, Ümit Mert, Alexandra Mackenzie, Ashley C W Pike

Science· February 2019

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The molecular basis for an allosteric inhibition of K-flux gating in K channels.
Susanne Rinné, Aytug K Kiper, Kirsty S Vowinkel, David Ramírez, Marcus Schewe

Elife· February 2019

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The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
Nicole Silbernagel, Magdalena Walecki, Martin K-H Schäfer, Mirjam Kessler, Mehrnoush Zobeiri, Marcus Schewe

FASEB J· November 2018

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Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.
Prafulla Aryal, Viwan Jarerattanachat, Michael V Clausen, Marcus Schewe, Conor McClenaghan

Structure· May 2017

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Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.
Niels Decher, Beatriz Ortiz-Bonnin, Corinna Friedrich, Marcus Schewe, Aytug K Kiper

EMBO Mol Med· April 2017

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Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
Conor McClenaghan, Marcus Schewe, Prafulla Aryal, Elisabeth P Carpenter, Thomas Baukrowitz

J Gen Physiol· June 2016

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A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.
Marcus Schewe, Ehsan Nematian-Ardestani, Han Sun, Marianne Musinszki, Sönke Cordeiro

Cell· February 2016

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