Publications by authors named "Marcus W Brazier"

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Antioxidant and Metal Chelation-Based Therapies in the Treatment of Prion Disease.
Marcus W Brazier, Anthony G Wedd, Steven J Collins

Antioxidants (Basel)· April 2014

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Immunotherapeutic approaches in prion disease: progress, challenges and potential directions.
Marcus W Brazier, Alexandra I Mot, Anthony R White, Steven J Collins

Ther Deliv· May 2013

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Metal attenuating therapies in neurodegenerative disease.
Alexandra I Mot, Anthony G Wedd, Layla Sinclair, David R Brown, Steven J Collins, Marcus W Brazier

Expert Rev Neurother· December 2011

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Manganese chelation therapy extends survival in a mouse model of M1000 prion disease.
Marcus W Brazier, Irene Volitakis, Magda Kvasnicka, Anthony R White, John R Underwood

J Neurochem· July 2010

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Dynamics of a truncated prion protein, PrP(113-231), from (15)N NMR relaxation: order parameters calculated and slow conformational fluctuations localized to a distinct region.
Denis B D O'Sullivan, Christopher E Jones, Salama R Abdelraheim, Marcus W Brazier, Harold Toms

Protein Sci· February 2009

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Therapeutic interventions ameliorating prion disease.
Marcus W Brazier, Vanessa A Wall, Barry W Brazier, Colin L Masters, Steven J Collins

Expert Rev Anti Infect Ther· February 2009

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A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease.
Marcus W Brazier, Susan R Doctrow, Colin L Masters, Steven J Collins

Free Radic Biol Med· July 2008

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Manganese binding to the prion protein.
Marcus W Brazier, Paul Davies, Esmie Player, Frank Marken, John H Viles

J Biol Chem· May 2008

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NMR characterization of the pH 4 beta-intermediate of the prion protein: the N-terminal half of the protein remains unstructured and retains a high degree of flexibility.
Denis B D O'Sullivan, Christopher E Jones, Salama R Abdelraheim, Andrew R Thompsett, Marcus W Brazier

Biochem J· January 2007

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Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals.
Rebecca C Nadal, Salama R Abdelraheim, Marcus W Brazier, Stephen E J Rigby, David R Brown

Free Radic Biol Med· January 2007

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Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression.
Tamuna Lekishvili, Shirley Hesketh, Marcus W Brazier, David R Brown

Eur J Neurosci· December 2006

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High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation.
Eva Zerovnik, Katja Skerget, Magda Tusek-Znidaric, Corina Loeschner, Marcus W Brazier

FEBS J· September 2006

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Correlative studies support lipid peroxidation is linked to PrP(res) propagation as an early primary pathogenic event in prion disease.
Marcus W Brazier, Victoria Lewis, Giuseppe D Ciccotosto, Genevieve M Klug, Victoria A Lawson

Brain Res Bull· January 2006

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Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.
Fang F Yuan, Sandra Biffin, Marcus W Brazier, Monica Suarez, Roberto Cappai

Immunol Cell Biol· December 2005

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Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control.
Steven J Collins, Victoria Lewis, Marcus W Brazier, Andrew F Hill, Victoria A Lawson

Neurobiol Dis· November 2005

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Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.
Anthony R White, Fran Maher, Marcus W Brazier, Michael F Jobling, James Thyer

Brain Res· March 2003

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