Publications by authors named "Maria Hytti"

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Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort.
Mikko Liukkonen, Hanna Heloterä, Leea Siintamo, Bishwa Ghimire, Pirkko Mattila, Maria Hytti, Juha Hyttinen

Invest Ophthalmol Vis Sci· November 2024

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Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage.
Maija Toppila, Sofia Ranta-Aho, Kai Kaarniranta, Maria Hytti, Anu Kauppinen

Cells· August 2024

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Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells.
Yashavanthi Mysore, Maria Hytti, Ashik Jawahar Deen, Sofia Ranta-Aho, Niina Piippo

Cell Biochem Biophys· June 2024

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Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery.
Niina Harju, Maria Hytti, Onni Kolari, Hilkka Nisula, Sirpa Loukovaara

Int Ophthalmol· March 2024

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Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells.
Eveliina Korhonen, Niina Piippo, Maria Hytti, Kai Kaarniranta, Anu Kauppinen

Biochem Pharmacol· October 2023

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Crosstalk of protein clearance, inflammasome, and Ca channels in retinal pigment epithelium derived from age-related macular degeneration patients.
Viivi Karema-Jokinen, Ali Koskela, Maria Hytti, Heidi Hongisto, Taina Viheriälä

J Biol Chem· June 2023

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The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance.
Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-Aho, Niina Harju

Antioxidants (Basel)· June 2023

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Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells.
Maria Hytti, Johanna Ruuth, Iiris Kanerva, Niina Bhattarai, Maria L Pedersen

Mol Cell Biochem· January 2023

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Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions.
Niina Bhattarai, Maria Hytti, Mika Reinisalo, Kai Kaarniranta, Yashavanthi Mysore

Immunol Res· October 2022

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Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells.
Iswariyaraja Sridevi Gurubaran, Maria Hytti, Kai Kaarniranta, Anu Kauppinen

Antioxidants (Basel)· June 2022

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Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells.
Eveliina Korhonen, Maria Hytti, Niina Piippo, Kai Kaarniranta, Anu Kauppinen

Exp Eye Res· August 2021

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Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration.
Maria Hytti, Eveliina Korhonen, Heidi Hongisto, Kai Kaarniranta, Heli Skottman

Int J Mol Sci· June 2021

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TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells.
Sofia Ranta-Aho, Niina Piippo, Eveliina Korhonen, Kai Kaarniranta, Maria Hytti

Int J Mol Sci· May 2021

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Only IL-1β release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted.
Eveliina Korhonen, Niina Piippo, Maria Hytti, Juha M T Hyttinen, Kai Kaarniranta

FASEB J· May 2020

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UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells.
Eveliina Korhonen, Jovana Bisevac, Juha M T Hyttinen, Niina Piippo, Maria Hytti

Invest Ophthalmol Vis Sci· April 2020

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Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy.
Maria Hytti, Eveliina Korhonen, Juha M T Hyttinen, Heidi Roehrich, Kai Kaarniranta

Oxid Med Cell Longev· August 2019

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SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1β-stimulated human retinal pigment epithelial cells.
Eveliina Korhonen, Niina Piippo, Maria Hytti, Juha M T Hyttinen, Kai Kaarniranta

Cytokine· April 2019

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Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy.
Niina Piippo, Eveliina Korhonen, Maria Hytti, Kati Kinnunen, Kai Kaarniranta

Cell Physiol Biochem· September 2018

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Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome.
Niina Piippo, Eveliina Korhonen, Maria Hytti, Heli Skottman, Kati Kinnunen

Sci Rep· April 2018

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NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.
Sirpa Loukovaara, Niina Piippo, Kati Kinnunen, Maria Hytti, Kai Kaarniranta

Acta Ophthalmol· December 2017

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Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells.
Maria Hytti, Dora Szabó, Niina Piippo, Eveliina Korhonen, Paavo Honkakoski

J Nutr Biochem· April 2017

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Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.
Maria Hytti, Niina Piippo, Eveliina Korhonen, Paavo Honkakoski, Kai Kaarniranta

Sci Rep· December 2015

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Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells.
Maria Hytti, Niina Piippo, Antero Salminen, Paavo Honkakoski, Kai Kaarniranta

Exp Eye Res· March 2015

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Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists.
Sari Yrjölä, Mirkka Sarparanta, Anu J Airaksinen, Maria Hytti, Anu Kauppinen

Eur J Pharm Sci· January 2015

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Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells.
Niina Piippo, Ayhan Korkmaz, Maria Hytti, Kati Kinnunen, Antero Salminen

Biochim Biophys Acta· December 2014

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