Publications by authors named "Maria J Comin"

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Enabling the serodiagnosis of American tegumentary leishmaniasis using synthetic aminopentyl-galactofuranoside-containing oligosaccharide epitopes.
Carolina S Touloumdjian, Emelie E Reuber, Fabienne Weber, Renato E Uncos, Eleonora Elhalem, María J Comin

Org Biomol Chem· December 2025

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Novel DAG-Lactone-Based Vav1 Inhibitors Show Anti-proliferative Activity in Pancreatic Cancer Models.
Ana Bellomo, Murat Toruner, Eleonora Elhalem, Megan L Peach, Lucía Gandolfi Donadío, María J Comin

ChemMedChem· November 2025

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Design, Synthesis, and Characterization of Novel -1 Heterocyclic DAG-Lactones as PKC Activators.
Eleonora Elhalem, Ana Bellomo, Mariana Cooke, Antonella Scravaglieri, Larry V Pearce, María J Comin

J Med Chem· August 2021

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Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer.
Matías S Ciarlantini, Andrea Barquero, Juan Bayo, Diana Wetzler, Martín M Dodes Traian, Maria J Comin

ChemMedChem· March 2021

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Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.
Eleonora Elhalem, Lucía Gandolfi Donadío, Xiaoling Zhou, Nancy E Lewin, Lia C Garcia, María J Comin

Bioorg Med Chem· June 2017

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Anti-Selective Organocatalytic Michael Addition between Phenylacetaldehyde and Nitrostyrene.
Lucía Gandolfi Donadío, Mariana A Galetti, Gianluca Giorgi, Marcello Rasparini, Maria J Comin

J Org Chem· September 2016

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Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride.
Marina Santos, Lia C García, Cintia Checura, Lucía Gandolfi Donadío, Carlos Fernandez, Maria J Comin

J Pharm Biomed Anal· October 2015

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Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.
Georgina A Cardama, Maria J Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe

Anticancer Agents Med Chem· March 2015

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Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells.
Georgina A Cardama, Nazareno Gonzalez, Matias Ciarlantini, Lucia Gandolfi Donadío, María Julieta Comin

Onco Targets Ther· November 2014

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Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Lia C Garcia, Lucia Gandolfi Donadío, Ella Mann, Sofiya Kolusheva, Noemi Kedei, Maria J Comin

Bioorg Med Chem· June 2014

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New human papilloma virus E2 transcription factor mimics: a tripyrrole-peptide conjugate with tight and specific DNA-recognition.
Diana E Wetzler, Maria J Comin, Krzysztof Krajewski, Mariana Gallo

PLoS One· December 2011

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[Rho GTPases as therapeutic targets in cancer and other human diseases].
Pablo Lorenzano Menna, Georgina A Cardama, María J Comin, Daniel F Alonso, Daniel E Gómez

Medicina (B Aires)· November 2011

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Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities.
Or Raifman, Sofiya Kolusheva, Maria J Comin, Noemi Kedei, Nancy E Lewin

FEBS J· January 2010

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Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
Maria J Comin, Gabriella Czifra, Noemi Kedei, Andrea Telek, Nancy E Lewin

J Med Chem· May 2009

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Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface.
Liron Philosof-Mazor, Roman Volinsky, Maria J Comin, Nancy E Lewin, Noemi Kedei

Langmuir· October 2008

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D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
Maria J Comin, B Christie Vu, Paul L Boyer, Chenzhong Liao, Stephen H Hughes

ChemMedChem· July 2008

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Rearranging the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve binding recognition by kinases.
Victor E Marquez, Maria J Comin

Nucleosides Nucleotides Nucleic Acids· February 2008

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Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase.
Maria J Comin, Riad Agbaria, Tsipi Ben-Kasus, Mahmoud Huleihel, Chenzhong Liao

J Am Chem Soc· May 2007

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Synthesis of bicyclo[3.1.0]hexanes functionalized at the tip of the cyclopropane ring. Application to the synthesis of carbocyclic nucleosides.
Maria J Comin, Damon A Parrish, Jeffrey R Deschamps, Victor E Marquez

Org Lett· February 2006

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Understanding how the herpes thymidine kinase orchestrates optimal sugar and nucleobase conformations to accommodate its substrate at the active site: a chemical approach.
Victor E Marquez, Yongseok Choi, Maria Julieta Comin, Pamela Russ, Clifford George

J Am Chem Soc· November 2005

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Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.
Zhan-Guo Gao, Lak Shin Jeong, Hyung Ryong Moon, Hea Ok Kim, Won Jun Choi, Maria J Comin

Biochem Pharmacol· March 2004

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A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
Yongseok Choi, Clifford George, Maria J Comin, Joseph J Barchi, Hak Sung Kim

J Med Chem· July 2003

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New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
Juan B Rodríguez, María J Comin

Mini Rev Med Chem· March 2003

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