Publications by authors named "Maria N Modica"

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Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells.
Loredana Salerno, Valeria Sorrenti, Valeria Pittalà, Valeria Consoli, Maria N Modica

ChemMedChem· April 2023

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Structure-activity relationships of mixed σR/σR ligands with antiproliferative and anticancer effects.
Antonino N Fallica, Valeria Ciaffaglione, Maria N Modica, Valeria Pittalà, Loredana Salerno

Bioorg Med Chem· November 2022

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Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use.
Lisa L Wilson, Shainnel O Eans, Insitar Ramadan-Siraj, Maria N Modica, Giuseppe Romeo

Int J Mol Sci· January 2022

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Mutual Prodrugs of 5-Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs.
Valeria Ciaffaglione, Maria N Modica, Valeria Pittalà, Giuseppe Romeo, Loredana Salerno

ChemMedChem· December 2021

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Development of New Benzylpiperazine Derivatives as σ Receptor Ligands with Antinociceptive and Anti-Allodynic Effects.
Giuseppe Romeo, Federica Bonanno, Lisa L Wilson, Emanuela Arena, Maria N Modica

ACS Chem Neurosci· June 2021

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Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective.
Antonino N Fallica, Valeria Pittalà, Maria N Modica, Loredana Salerno, Giuseppe Romeo

J Med Chem· June 2021

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In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox.
Sebastiano Intagliata, Angelo Spadaro, Miriam Lorenti, Annamaria Panico, Edy A Siciliano, Maria N Modica

Antioxidants (Basel)· December 2020

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Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands.
Sebastiano Intagliata, Mohamed A Helal, Luisa Materia, Valeria Pittalà, Loredana Salerno, Maria N Modica

Molecules· April 2020

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[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT receptor.
Giuseppe Romeo, Loredana Salerno, Valeria Pittalà, Marialuisa Candido, Sebastiano Intagliata, Maria Nunziata Modica

Eur J Med Chem· December 2019

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Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.
Giuseppe Romeo, Orazio Prezzavento, Sebastiano Intagliata, Valeria Pittalà, Maria N Modica

Eur J Med Chem· July 2019

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Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update.
Sebastiano Intagliata, Maria N Modica, Ludovica M Santagati, Lucia Montenegro

Antioxidants (Basel)· July 2019

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Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy.
Lucia Montenegro, Anna Maria Panico, Ludovica Maria Santagati, Edy Angela Siciliano, Sebastiano Intagliata, Maria N Modica

Nanomaterials (Basel)· December 2018

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Structure-Activity Relationships and Therapeutic Potentials of 5-HT Receptor Ligands: An Update.
Maria N Modica, Enza Lacivita, Sebastiano Intagliata, Loredana Salerno, Giuseppe Romeo

J Med Chem· October 2018

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Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1.
Valeria Pittala, Luca Vanella, Loredana Salerno, Claudia Di Giacomo, Rosaria Acquaviva, Maria N Modica

Curr Pharm Des· May 2018

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Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation.
Khaled F Greish, Loredana Salerno, Reem Al Zahrani, Emanuele Amata, Maria N Modica

Molecules· May 2018

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Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.
Loredana Salerno, Giuseppe Romeo, Maria N Modica, Emanuele Amata, Valeria Sorrenti

Eur J Med Chem· December 2017

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Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors.
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N Modica, Loredana Salerno

Data Brief· December 2017

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Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N Modica, Loredana Salerno

ChemMedChem· November 2017

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In Vitro Antioxidant Activity of Idebenone Derivative-Loaded Solid Lipid Nanoparticles.
Lucia Montenegro, Maria N Modica, Loredana Salerno, Anna Maria Panico, Lucia Crascì

Molecules· May 2017

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New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT and 5-HT receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies.
Sebastiano Intagliata, Maria N Modica, Valeria Pittalà, Loredana Salerno, Maria A Siracusa

Bioorg Med Chem· February 2017

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S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands.
Giovanni Nastasi, Carla Miceli, Valeria Pittalà, Maria N Modica, Orazio Prezzavento

J Cheminform· January 2017

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Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.
Sebastiano Intagliata, Maria N Modica, Valeria Pittalà, Loredana Salerno, Maria A Siracusa

Bioorg Med Chem Lett· August 2016

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Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
Loredana Salerno, Valeria Pittalà, Giuseppe Romeo, Maria N Modica, Agostino Marrazzo

Eur J Med Chem· April 2016

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Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands.
Valeria Pittalà, Maria A Siracusa, Loredana Salerno, Giuseppe Romeo, Maria N Modica

Eur Neuropsychopharmacol· August 2015

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Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.
Maria N Modica, Sebastiano Intagliata, Valeria Pittalà, Loredana Salerno, Maria A Siracusa

Bioorg Med Chem Lett· April 2015

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