Publications by authors named "Mark A Applebaum"

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Outcomes for Patients Aged 12-18 Months With Metastatic MYCN Non-Amplified Neuroblastoma and Unfavorable Biologic Features ("Mixed Biology Toddlers"): A Report From the International Neuroblastoma Risk Group (INRG) Project.
Mallory R Taylor, James R Anderson, Julie R Park, Meredith S Irwin, Mark A Applebaum

Pediatr Blood Cancer· November 2025

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5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcoma.
Evan W Neczypor, Hailey Reisert, Kelley Moore, Elizabeth Zeldin, Robert A Dubin, Mark A Applebaum

Res Sq· September 2025

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5-hydroxymethylcytosine deposition mediates Polycomb Repressive Complex 2 function in -amplified neuroblastoma.
Mohansrinivas Chennakesavalu, Gabriel L Lopez, Varsha Gupta, Kelley Moore, Yuqing Xue, Mark A Applebaum

bioRxiv· July 2025

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Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity.
Yan-Hong Cui, Jiangbo Wei, Hao Fan, Wenlong Li, Lijie Zhao, Mark A Applebaum

Proc Natl Acad Sci U S A· December 2024

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Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.
Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Mark A Applebaum

NPJ Precis Oncol· November 2024

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Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures.
Maria E Kaufman, Omar R Vayani, Kelley Moore, Alexandre Chlenski, Tong Wu, Mark A Applebaum

Cancer Res Commun· August 2024

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Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation.
Monica Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhiwei Jiang, Hui-Lung Sun, Mark A Applebaum

Cell Rep· May 2024

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Diffuse Pediatric-type High-grade Glioma Arising in an Ovarian Mature Cystic Teratoma.
Lena Elmuti, Julia Amundson, Elise Oberman, Aarti Kamat, Laura Sedig, Mark A Applebaum

Int J Gynecol Pathol· January 2024

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Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Omar R Vayani, Maria E Kaufman, Kelley Moore, Mohansrinivas Chennakesavalu, Rachel TerHaar, Mark A Applebaum

Pediatr Blood Cancer· January 2024

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5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma.
Mohansrinivas Chennakesavalu, Kelley Moore, Gepoliano Chaves, Sahil Veeravalli, Rachel TerHaar, Mark A Applebaum

JCO Precis Oncol· January 2024

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Persistence of Racial and Ethnic Disparities in Risk and Survival for Patients with Neuroblastoma over Two Decades.
Mohansrinivas Chennakesavalu, Caileigh Pudela, Mark A Applebaum, Sang Mee Lee, Yan Che

EJC Paediatr Oncol· December 2023

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Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Omar R Vayani, Maria E Kaufman, Kelley Moore, Mohansrinivas Chennakesavalu, Rachel TerHaar, Mark A Applebaum

bioRxiv· September 2023

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Breaking Up Isn't Hard to Do: Isolating Cell-free DNA Fragments in Osteosarcoma.
Daniel A Weiser, Masanori Hayashi, Mark A Applebaum

Clin Cancer Res· June 2023

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Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model.
Isabella Iwanicki, Lydia L Wu, Fernando Flores-Guzman, Rachael Sundland, Paula Viza-Gomes, Mark A Applebaum

Int J Hyperthermia· June 2023

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T-cell inflammation is prognostic of survival in patients with high-risk neuroblastoma enriched for an adrenergic signature.
Maria E Kaufman, Omar R Vayani, Kelley Moore, Alexandre Chlenski, Tong Wu, Mark A Applebaum

bioRxiv· June 2023

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5-hydroxymethylcytosine profiling of cell-free DNA identifies bivalent genes that are prognostic of survival in high-risk neuroblastoma.
Mohansrinivas Chennakesavalu, Kelley Moore, Gepoliano Chaves, Sahil Veeravalli, Rachel TerHaar, Mark A Applebaum

bioRxiv· April 2023

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Methyltransferase Inhibition Enables Tgf Driven Induction of and in Cancer Cells.
Yen-Ting Liu, Celeste Romero, Xue Xiao, Lei Guo, Xiaoyun Zhou, Mark A Applebaum

Mol Cell Biol· March 2023

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Clinical Targeted Next-Generation Panel Sequencing Reveals Amplification Is a Poor Prognostic Factor in Osteosarcoma.
Amanda E Marinoff, Liam F Spurr, Christina Fong, Yvonne Y Li, Suzanne J Forrest, Mark A Applebaum

JCO Precis Oncol· March 2023

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MYCN and HIF-1 directly regulate expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.
Anastasia E Hains, Sakshi Uppal, John Z Cao, Helen R Salwen, Mark A Applebaum

Epigenetics· December 2022

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Systemic Bevacizumab for Severe Recurrent Respiratory Papillomatosis.
Swetha Tatineni, Zachary Warren, Mark A Applebaum, Fuad M Baroody

Case Rep Oncol Med· November 2022

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Efficacy of post-induction therapy for high-risk neuroblastoma patients with end-induction residual disease.
Ami V Desai, Mark A Applebaum, Theodore G Karrison, Akosua Oppong, Cindy Yuan

Cancer· August 2022

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Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer.
Alanna J Church, Laura B Corson, Pei-Chi Kao, Alma Imamovic-Tuco, Deirdre Reidy, Mark A Applebaum

Nat Med· August 2022

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Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor.
Jaclyn Schienda, Alanna J Church, Laura B Corson, Brennan Decker, Catherine M Clinton, Mark A Applebaum

JCO Precis Oncol· March 2022

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Predicting Response to Chemotherapy in Patients With Newly Diagnosed High-Risk Neuroblastoma: A Report From the International Neuroblastoma Risk Group.
Anoop Mayampurath, Siddhi Ramesh, Diana Michael, Liu Liu, Nicholas Feinberg, Mark A Applebaum

JCO Clin Cancer Inform· December 2021

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Applications of Artificial Intelligence in Pediatric Oncology: A Systematic Review.
Siddhi Ramesh, Sukarn Chokkara, Timothy Shen, Ajay Major, Samuel L Volchenboum, Mark A Applebaum

JCO Clin Cancer Inform· December 2021

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