Publications by authors named "Mark A Harris"

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Derivation of oral cancer slope factors for hexavalent chromium informed by pharmacokinetic models and in vivo genotoxicity data.
Chad M Thompson, Christopher Kirman, Mark A Harris

Regul Toxicol Pharmacol· December 2023

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Letter to "Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose-response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose-response data".
Chad M Thompson, Deborah M Proctor, Mark A Harris

Environ Mol Mutagen· April 2023

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Predictive modeling of biological responses in the rat liver using Tox21 bioactivity: Benefits from high-throughput toxicokinetics.
Caroline Ring, Nisha S Sipes, Jui-Hua Hsieh, Celeste Carberry, Lauren E Koval, Mark A Harris

Comput Toxicol· May 2021

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Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice.
Chad M Thompson, Douglas A Donahue, Cheryl Hobbs, Yanina Costecalde, Allison Franzen, Mark A Harris

Regul Toxicol Pharmacol· October 2020

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An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet.
Virunya S Bhat, Samuel M Cohen, Elliot B Gordon, Charles E Wood, John M Cullen, Mark A Harris

Crit Rev Toxicol· September 2020

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Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway.
Grace A Chappell, Julia E Rager, Jeffrey Wolf, Milos Babic, Kyle J LeBlanc, Mark A Harris

Toxicol Pathol· October 2019

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Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals.
William D Klaren, Caroline Ring, Mark A Harris, Chad M Thompson, Susan Borghoff

Toxicol Sci· January 2019

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Letter to the Editor Regarding Banu et al. (2018). Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis.
Chad M Thompson, Mina Suh, Deborah M Proctor, Mark A Harris

Toxicol Sci· October 2018

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Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium.
Chad M Thompson, Christopher R Kirman, Sean M Hays, Mina Suh, Seneca E Harvey, Mark A Harris

J Appl Toxicol· March 2018

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Comparison of Toxicity and Recovery in the Duodenum of B6C3F1 Mice Following Treatment with Intestinal Carcinogens Captan, Folpet, and Hexavalent Chromium.
Chad M Thompson, Jeffrey C Wolf, Alene McCoy, Mina Suh, Deborah M Proctor, Mark A Harris

Toxicol Pathol· December 2017

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Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents.
Chad M Thompson, Mina Suh, Deborah M Proctor, Laurie C Haws, Mark A Harris

Mutat Res Genet Toxicol Environ Mutagen· November 2017

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Assessment of the mutagenic potential of hexavalent chromium in the duodenum of big blue® rats.
Chad M Thompson, Robert R Young, Harshini Dinesdurage, Mina Suh, Mark A Harris

Toxicol Appl Pharmacol· September 2017

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Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data.
Anne Bichteler, Daniele S Wikoff, Francis Loko, Mark A Harris

Environ Int· August 2017

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High-Throughput Screening Data Interpretation in the Context of In Vivo Transcriptomic Responses to Oral Cr(VI) Exposure.
Julia E Rager, Caroline L Ring, Rebecca C Fry, Mina Suh, Deborah M Proctor, Mark A Harris

Toxicol Sci· July 2017

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Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment.
Chad M Thompson, Julia E Rager, Mina Suh, Caroline L Ring, Deborah M Proctor, Mark A Harris

Environ Mol Mutagen· December 2016

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Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling.
Christopher R Kirman, Mina Suh, Sean M Hays, Hakan Gürleyük, Russ Gerads, Mark A Harris

Toxicol Appl Pharmacol· September 2016

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Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium.
Chad M Thompson, Anne Bichteler, Julia E Rager, Mina Suh, Deborah M Proctor, Mark A Harris

Mutat Res Genet Toxicol Environ Mutagen· April 2016

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Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats.
Chad M Thompson, Robert R Young, Mina Suh, Harshini R Dinesdurage, Reem H Elbekai, Mark A Harris

Environ Mol Mutagen· August 2015

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Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy.
Chad M Thompson, Jeffrey C Wolf, Reem H Elbekai, Madhav G Paranjpe, Jennifer M Seiter, Mark A Harris

Mutat Res Genet Toxicol Environ Mutagen· August 2015

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Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.
Chad M Thompson, Jennifer Seiter, Mark A Chappell, Ryan V Tappero, Deborah M Proctor, Mark A Harris

Toxicol Sci· January 2015

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A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.
Chad M Thompson, Christopher R Kirman, Deborah M Proctor, Laurie C Haws, Mina Suh, Mark A Harris

J Appl Toxicol· May 2014

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High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice.
Mina Suh, Chad M Thompson, Christopher R Kirman, Michael C Carakostas, Laurie C Haws, Mark A Harris

Food Chem Toxicol· March 2014

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A review of background dioxin concentrations in urban/suburban and rural soils across the United States: implications for site assessments and the establishment of soil cleanup levels.
Jonathan D Urban, Daniele S Wikoff, Alea T G Bunch, Mark A Harris, Laurie C Haws

Sci Total Environ· January 2014

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Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.
Travis J O'Brien, Hao Ding, Mina Suh, Chad M Thompson, Barbara L Parsons, Mark A Harris

Mutat Res· June 2013

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Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.
Chad M Thompson, Deborah M Proctor, Mina Suh, Laurie C Haws, Christopher R Kirman, Mark A Harris

Crit Rev Toxicol· March 2013

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