Publications by authors named "Mark A Varney"

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NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy.
Per Svenningsson, Per Odin, Filip Bergquist, Karin Wirdefeldt, Dag Nyholm, Mark A Varney

Mov Disord· June 2025

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Rescue of respiratory and cognitive impairments in Rett Syndrome mice using NLX-101, a selective 5-HT receptor biased agonist.
Daniela Monteiro-Fernandes, Ian Charles, Sara Guerreiro, Daniela Cunha-Garcia, Joana Pereira-Sousa, Mark A Varney

Biomed Pharmacother· May 2025

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Pharmacodynamic, pharmacokinetic and rat brain receptor occupancy profile of NLX-112, a highly selective 5-HT receptor biased agonist.
Ronan Y Depoortère, Andrew C McCreary, Benjamin Vidal, Mark A Varney, Luc Zimmer

Naunyn Schmiedebergs Arch Pharmacol· January 2025

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The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat.
Magdalena Jastrzębska-Więsek, Anna Wesołowska, Marcin Kołaczkowski, Mark A Varney, Adrian Newman-Tancredi

Behav Pharmacol· August 2022

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Dissecting the contribution of 5-HT auto- and heteroreceptors in sucrose overconsumption in mice.
Kate Beecher, Joshua Wang, Fatemeh Chehrehasa, Ronan Depoortere, Mark A Varney

Biomed Pharmacother· April 2022

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Identification of the 5-HT serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease.
Joana Pereira-Sousa, Bruna Ferreira-Lomba, Aina Bellver-Sanchis, Daniela Vilasboas-Campos, Jorge H Fernandes, Mark A Varney

Neurobiol Dis· May 2021

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The selective 5-HT receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets.
Ria Fisher, Atsuko Hikima, Rebecca Morris, Michael J Jackson, Sarah Rose, Mark A Varney

Neuropharmacology· May 2020

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Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model.
Ronan Depoortère, Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Monika Niemczyk, Mark A Varney

J Psychopharmacol· November 2019

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Serotonin 5-HT Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.
Ronan Depoortère, Laurent Bardin, Mark A Varney, Adrian Newman-Tancredi

ACS Chem Neurosci· July 2019

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Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT receptor sensitivity.
Deborah G A Peeters, Sietse F de Boer, Anneke Terneusen, Adrian Newman-Tancredi, Mark A Varney

Neuropharmacology· July 2019

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Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT Receptor-Biased Agonists with Robust Antidepressant-like Activity.
Joanna Sniecikowska, Monika Gluch-Lutwin, Adam Bucki, Anna Więckowska, Agata Siwek, Mark A Varney

J Med Chem· March 2019

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Activity of Serotonin 5-HT Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties.
Magdalena Jastrzębska-Więsek, Anna Partyka, Joanna Rychtyk, Joanna Śniecikowska, Marcin Kołaczkowski, Mark A Varney

ACS Chem Neurosci· May 2018

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Effects of the Serotonin 5-HT Receptor Biased Agonists, F13714 and F15599, on Striatal Neurotransmitter Levels Following L-DOPA Administration in Hemi-Parkinsonian Rats.
Adrian Newman-Tancredi, Mark A Varney, Andrew C McCreary

Neurochem Res· May 2018

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Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT receptor selective agonist, NLX-112 in mouse models of pain.
Kinga Sałat, Marcin Kołaczkowski, Anna Furgała, Adriana Rojek, Joanna Śniecikowska, Mark A Varney

Neuropharmacology· October 2017

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Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT receptor agonist.
Adrian Newman-Tancredi, Jean-Claude Martel, Cristina Cosi, Peter Heusler, Fabrice Lestienne, Mark A Varney

J Pharm Pharmacol· September 2017

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The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements.
Andrew C McCreary, Mark A Varney, Adrian Newman-Tancredi

Neuropharmacology· June 2016

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Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.
Seth C Hopkins, Una C Campbell, Michele L R Heffernan, Kerry L Spear, Ross D Jeggo, Mark A Varney

Pharmacol Res Perspect· October 2013

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Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
Seth C Hopkins, Fei-Yue Zhao, Carrie A Bowen, Xin Fang, Haifeng Wei, Mark A Varney

J Pharmacol Exp Ther· June 2013

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Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
Seth C Hopkins, Michele L R Heffernan, Lakshmi D Saraswat, Carrie A Bowen, Laurence Melnick, Mark A Varney

J Med Chem· May 2013

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Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.
Rudolf Mueller, Stanislaw Rachwal, Mark A Varney, Steven A Johnson, Kashinatham Alisala

Bioorg Med Chem Lett· December 2011

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Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.
Liming Shao, Michael C Hewitt, Scott C Malcolm, Fengjiang Wang, Jianguo Ma, Mark A Varney

J Med Chem· August 2011

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Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.
Liming Shao, Michael C Hewitt, Fengjiang Wang, Scott C Malcolm, Jianguo Ma, Mark A Varney

Bioorg Med Chem Lett· March 2011

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Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.
Liming Shao, Michael C Hewitt, Fengjiang Wang, Scott C Malcolm, Jianguo Ma, Mark A Varney

Bioorg Med Chem Lett· March 2011

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Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Liming Shao, Fengjiang Wang, Scott C Malcolm, Jianguo Ma, Michael C Hewitt, Mark A Varney

Bioorg Med Chem· January 2011

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Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.
Liming Shao, Jianguo Ma, Fengjiang Wang, Scott C Malcolm, Michael C Hewitt, Mark A Varney

Bioorg Med Chem Lett· January 2011

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