Publications by authors named "Mark Avigan"

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Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform.
Qiang Shi, Laura K Schnackenberg, Lijun Ren, Katy S Papineau, Jessica J H Oliphant, Mark I Avigan

Toxicol Lett· November 2025

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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice.
Volodymyr P Tryndyak, Rose A Willett, Zhuolin Song, Kostiantyn Dreval, Jennifer M Hughes Hanks, Mark I Avigan

Toxicol Appl Pharmacol· September 2025

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The Impact of COVID-19 and COVID-19 Vaccination on Detection, Assessment, and Management of Suspected Acute Drug-Induced Liver Injury Occurring during Clinical Trials: Consensus Recommendations from the IQ DILI Initiative.
Melissa Palmer, Daniel Seekins, Mark Avigan, John Marcinak, Don C Rockey

Drug Saf· August 2025

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R Value-Based Criteria Outperform Alkaline Phosphatase Less than Twice Normal in Identifying Hy's Law Cases in Clinical Trials.
Jasmine Amirzadegan, Edwige Chiogo Vouffo, Ling Lan, Eileen Navarro Almario, Mark I Avigan

Drug Saf· August 2025

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Emerging Tools to Support DILI Assessment in Clinical Trials with Abnormal Baseline Serum Liver Tests or Pre-existing Liver Diseases.
Jasmine Amirzadegan, Bereket Tesfaldet, Y Veronica Pei, Eileen Navarro Almario, Mark I Avigan

Drug Saf· May 2025

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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice.
Rose A Willett, Volodymyr P Tryndyak, Jennifer M Hughes Hanks, Lana Elkins, Suresh K Nagumalli, Mark I Avigan

Toxicol Appl Pharmacol· October 2024

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Correction to: Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative.
Eric B Cohen, Meenal Patwardhan, Ritu Raheja, David H Alpers, Raul J Andrade, Mark I Avigan

Drug Saf· May 2024

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Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative.
Eric B Cohen, Meenal Patwardhan, Ritu Raheja, David H Alpers, Raul J Andrade, Mark I Avigan

Drug Saf· April 2024

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Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations.
Alexander Pop, Dina Halegoua-DeMarzio, Huiman Barnhart, David Kleiner, Mark Avigan

Dig Dis Sci· April 2024

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Liver biopsy for assessment of suspected drug-induced liver injury in metabolic dysfunction-associated steatohepatitis clinical trials: Expert consensus from the Liver Forum.
Melissa Palmer, David E Kleiner, Zachary Goodman, Elizabeth Brunt, Mark I Avigan

Aliment Pharmacol Ther· January 2024

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Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report.
Raúl J Andrade, Guruprasad P Aithal, Ynto S de Boer, Rodrigo Liberal, Alexander Gerbes, Mark Avigan

J Hepatol· September 2023

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Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice.
Volodymyr P Tryndyak, Rose A Willett, Suresh K Nagumalli, Dan Li, Mark I Avigan

Am J Physiol Gastrointest Liver Physiol· March 2023

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Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet.
Volodymyr P Tryndyak, Rose A Willett, Mark I Avigan, Arun J Sanyal, Frederick A Beland

Epigenetics· November 2022

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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice.
Suresh K Nagumalli, Rose A Willett, Aline de Conti, Volodymyr P Tryndyak, Mark I Avigan

J Nutr Biochem· November 2022

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Acute Cholecystitis Associated With the Use of Glucagon-Like Peptide-1 Receptor Agonists Reported to the US Food and Drug Administration.
Daniel Woronow, Christine Chamberlain, Ali Niak, Mark Avigan, Monika Houstoun

JAMA Intern Med· October 2022

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Co-Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver-Chip for the Study of Drug-Induced Liver Injury.
Qiang Shi, Ayesha Arefin, Lijun Ren, Katy S Papineau, Dustyn A Barnette, Mark Avigan

Curr Protoc· July 2022

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John R. Senior, MD.
Mark Avigan, Paul B Watkins

Hepatology· May 2022

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Repeated or Continuous Medically Supervised Ketamine Administration Associated with Hepatobiliary Adverse Events: A Retrospective Case Series.
Samantha Cotter, Jennie Wong, Neha Gada, Rajdeep Gill, S Christopher Jones, Mark Avigan

Drug Saf· December 2021

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Deciphering the Dynamic Complexities of the Liver Microenvironment - Toward a Better Understanding of Immune-Mediated liver Injury Caused by Immune Checkpoint Inhibitors (ILICI).
Tao Wang, Matthew M Yeh, Mark I Avigan, Lorraine Pelosof, Gerald M Feldman

AAPS J· August 2021

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A case series analysis of serious exacerbations of viral hepatitis and non-viral hepatic injuries in tocilizumab-treated patients.
Ann Biehl, Lisa Harinstein, Allen Brinker, Rachel Glaser, Monica Muñoz, Mark Avigan

Liver Int· March 2021

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Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis.
William R Treem, Melissa Palmer, Isabelle Lonjon-Domanec, Daniel Seekins, Lara Dimick-Santos, Mark I Avigan

Drug Saf· February 2021

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An Evaluation of Postmarketing Reports of Serious Idiosyncratic Liver Injury Associated with Ulipristal Acetate for the Treatment of Uterine Fibroids.
Sarah Kang, Allen Brinker, S Christopher Jones, Lara Dimick-Santos, Mark I Avigan

Drug Saf· December 2020

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Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.
Arie Regev, Mark I Avigan, Alexandre Kiazand, John M Vierling, James H Lewis

J Autoimmun· November 2020

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Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model.
Aline de Conti, Volodymyr Tryndyak, Rose A Willett, Barbara Borowa-Mazgaj, Anna Watson, Mark I Avigan

FASEB J· June 2020

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Liver safety assessment in clinical trials of new agents for chronic hepatitis B.
Robert J Fontana, Mark I Avigan, Harry L A Janssen, Arie Regev, Poonam Mishra

J Viral Hepat· February 2020

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