Publications by authors named "Mark Brimble"

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Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms.
Paul B Conway, Livia Autore, Andrea Muñoz Zamora, Antoine Harel, Zijun Wang, Mark A Brimble

PLoS Biol· September 2025

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Deconstruction of a Memory Engram Reveals Distinct Ensembles Recruited at Learning.
Clément Pouget, Flora Morier, Nadja Treiber, Pablo Fernández García, Nina Mazza, Mark A Brimble

Res Sq· February 2025

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Non-encapsidated miRNA contaminants found in AAV preparations.
Mark A Brimble, Stephen M Winston

Mol Ther Methods Clin Dev· December 2024

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Single cell and TCR analysis of immune cells from AAV gene therapy-dosed Duchenne muscular dystrophy patients.
Michael R Emami, Mark A Brimble, Alejandro Espinoza, Jane Owens, Laurence O Whiteley

Mol Ther Methods Clin Dev· December 2024

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Deconstruction of a memory engram reveals distinct ensembles recruited at learning.
Clément Pouget, Flora Morier, Nadja Treiber, Pablo Fernández García, Nina Mazza, Mark A Brimble

bioRxiv· December 2024

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rAAV expressing a COBRA-designed influenza hemagglutinin generates a protective and durable adaptive immune response with a single dose.
Kristin B Wiggins, Stephen M Winston, Isaiah L Reeves, Jessica Gaevert, Yunyu Spence, Mark A Brimble

J Virol· August 2024

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Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification.
Anas Reda, Luca A Hategan, Timothy A B McLean, Samantha D Creighton, Jian Qi Luo, Mark A Brimble

Neuropsychopharmacology· July 2024

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Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer.
Mark A Brimble, Christopher L Morton, Stephen M Winston, Isaiah L Reeves, Yunyu Spence

Hum Gene Ther· July 2024

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Threat-dependent scaling of prelimbic dynamics to enhance fear representation.
José Patricio Casanova, Clément Pouget, Nadja Treiber, Ishaant Agarwal, Mark Allen Brimble

Neuron· July 2024

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Preventing bad behavior in academia.
Rayane da Cruz Albino, Mark Allen Brimble, Christina Zdenek, Katrien Vandenbroeck, Sarah Masud

Science· July 2024

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The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.
Amanda M Leonetti, Isabella R Galluzzo, Timothy A D McLean, Gilda Stefanelli, Fiona Ramnaraign, Mark A Brimble

Neurobiol Learn Mem· April 2024

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Stowaways in the cargo: Contaminating nucleic acids in rAAV preparations for gene therapy.
Mark A Brimble, Stephen M Winston, Andrew M Davidoff

Mol Ther· October 2023

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Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice.
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A Brimble, Samantha D Creighton

Commun Biol· May 2022

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Author Correction: Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice.
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A Brimble, Samantha D Creighton

Commun Biol· May 2022

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Preventing packaging of translatable P5-associated DNA contaminants in recombinant AAV vector preps.
Mark A Brimble, Pei-Hsin Cheng, Stephen M Winston, Isaiah L Reeves, Aisha Souquette

Mol Ther Methods Clin Dev· March 2022

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Off-Target Expression of Cre-Dependent Adeno-Associated Viruses in Wild-Type C57BL/6J Mice.
Justin J Botterill, Abdessattar Khlaifia, Brandon J Walters, Mark A Brimble, Helen E Scharfman

eNeuro· December 2021

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The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons.
Gilda Stefanelli, Claire E Makowski, Mark A Brimble, Meaghan Hall, Anas Reda

Cell Rep· August 2021

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Self-complementarity in adeno-associated virus enhances transduction and gene expression in mouse cochlear tissues.
Graham Casey, Charles Askew, Mark A Brimble, R Jude Samulski, Andrew M Davidoff

PLoS One· January 2021

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KDM5A Regulates a Translational Program that Controls p53 Protein Expression.
Dongli Hu, Carolyn Jablonowski, Pei-Hsin Cheng, Alaa AlTahan, Chunliang Li, Mark Brimble

iScience· November 2018

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Spring Forward: ESGCT Trains the Next Generation of Gene and Cell Therapists.
Vanessa M A Woods, Mark A Brimble

Hum Gene Ther· October 2018

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Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus.
Gilda Stefanelli, Amber B Azam, Brandon J Walters, Mark A Brimble, Caroline P Gettens

Cell Rep· January 2018

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New and improved AAVenues: current status of hemophilia B gene therapy.
Mark A Brimble, Ulrike M Reiss, Amit C Nathwani, Andrew M Davidoff

Expert Opin Biol Ther· September 2016

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High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor.
Brandon J Walters, Wenwei Lin, Shiyong Diao, Mark Brimble, Luigi I Iconaru

PLoS One· December 2014

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Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.
Zhiyong Liu, Brandon J Walters, Thomas Owen, Mark A Brimble, Katherine A Steigelman

J Neurosci· August 2012

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