Publications by authors named "Mark Chance"

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Redox Stoichiometry at the Single-Residue Level Using Mass Spectrometry Reveals Dynamic Methionine Sulfoxide Speciation in Actin and Calmodulin during Brain Aging.
Jiwoo Hwang, Madeleine F Clore, Filipa Blasco Tavares Pereira Lopes, Marzieh Ayati, Daniela Schlatzer, Mark R Chance

J Proteome Res· December 2025

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Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer's disease.
Lenka Hromadkova, Chae Kim, Tracy Haldiman, Mohammad Khursheed Siddiqi, Krystyna Surewicz, Mark R Chance

PLoS Pathog· June 2025

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Quantitative readout of methionine residue solvent accessibility in E. coli cells using radiolytic hydroxyl radical labeling and mass spectrometry.
Ezaz Ahmed, Rohit Jain, Daniela Schlatzer, Filipa Blasco Tavares Pereira Lopes, Janna Kiselar, Mark R Chance

Biochem Biophys Res Commun· May 2025

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Trained mesenchymal stromal cell-based therapy HXB-319 for treating diffuse alveolar hemorrhage in a pristane-induced murine model.
Hulya Bukulmez, Adrienne T Dennis, Jane Reese-Koc, Scott F Sieg, Brian Clagett, Mark Chance

Stem Cells· February 2025

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Multiplex Trifluoromethyl and Hydroxyl Radical Chemistry Enables High-Resolution Protein Footprinting.
Rohit Jain, Erik R Farquhar, Nanak S Dhillon, Nayeon Jeon, Mark R Chance

Anal Chem· January 2025

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Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteome.
Serhan Yılmaz, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Rihua Wang, Xin Qi, Mark R Chance

iScience· October 2024

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Mass Spectrometry-Based Protein Footprinting Defines the Binding Pocket of Crotonylated H3K14 in the PHD1 Domain of BAF45D within the BAF Chromatin Remodeling Complex.
Marissa R Martinez, Janna Kiselar, Benlian Wang, Dipti Sadalge, Laura Zawadzke, Mark R Chance

ACS Bio Med Chem Au· August 2024

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An engineered lactate oxidase based electrochemical sensor for continuous detection of biomarker lactic acid in human sweat and serum.
Qingrong He, Cheng Wang, Rohit Jain, James Byrnes, Erik R Farquhar, Mark R Chance

Heliyon· July 2024

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Methionine Sulfoxide Speciation in Mouse Hippocampus Revealed by Global Proteomics Exhibits Age- and Alzheimer's Disease-Dependent Changes Targeted to Mitochondrial and Glycolytic Pathways.
Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yilmaz, Rihua Wang, Mark R Chance

Int J Mol Sci· June 2024

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Making proteomics accessible: RokaiXplorer for interactive analysis of phospho-proteomic data.
Serhan Yılmaz, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Marzieh Ayati, Mark R Chance

Bioinform Adv· June 2024

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Evaluating Mass Spectrometry-Based Hydroxyl Radical Protein Footprinting of a Benchtop Flash Oxidation System against a Synchrotron X-ray Beamline.
Rohit Jain, Nanak S Dhillon, Vijaya Lakshmi Kanchustambham, David T Lodowski, Erik R Farquhar, Mark R Chance

J Am Soc Mass Spectrom· March 2024

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Human alveolar macrophages display marked hypo-responsiveness to IFN-γ in both proteomic and gene expression analysis.
Bonnie A Thiel, Kathleen C Lundberg, Daniela Schlatzer, Jessica Jarvela, Qing Li, Mark R Chance

PLoS One· February 2024

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Intact mass spectrometry screening to optimize hydroxyl radical dose for protein footprinting.
Erik R Farquhar, Kanchustambham Vijayalakshmi, Rohit Jain, Benlian Wang, Janna Kiselar, Mark R Chance

Biochem Biophys Res Commun· September 2023

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Military Medicine and Medical Research as a Source of Inspiration and Innovation to Solve National Security and Health Challenges in the 21st Century.
Nanak S Dhillon, Nayeon Jeon, Umut A Gurkan, Anirban Sen Gupta, Robert A Bonomo, Mark R Chance

Pathog Immun· September 2023

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Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome.
Serhan Yılmaz, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Rihua Wang, Xin Qi, Mark R Chance

bioRxiv· August 2023

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Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.
Wei Huang, Hongyun Li, Janna Kiselar, Stephen P Fink, Sagar Regmi, Mark Chance

Nat Commun· February 2023

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Prediction of Kinase-Substrate Associations Using The Functional Landscape of Kinases and Phosphorylation Sites.
Marzieh Ayati, Serhan Yilmaz, Filipa Blasco Tavares Pereira Lopes, Mark Chance, Mehmet Koyuturk

Pac Symp Biocomput· December 2022

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Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease.
Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Rihua Wang, Xiaolin Li, Emily Feng, Mark R Chance

Mol Cell Proteomics· September 2022

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Functional characterization of co-phosphorylation networks.
Marzieh Ayati, Serhan Yılmaz, Mark R Chance, Mehmet Koyuturk

Bioinformatics· August 2022

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Multiplex Chemical Labeling of Amino Acids for Protein Footprinting Structure Assessment.
Rohit Jain, Nanak S Dhillon, Erik R Farquhar, Benlian Wang, Xiaolin Li, Mark R Chance

Anal Chem· July 2022

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Training the next generation of translational scientists: The Case Western Reserve University Translational Fellows Program.
Cheryl L Thompson, Tessianna A Misko, Mark R Chance

J Clin Transl Sci· April 2022

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Optimizing biomedical discoveries as an engine of culture change in an academic medical center.
Anne K DeChant, Stephen Fening, Michael Haag, William Harte, Mark R Chance

J Clin Transl Sci· January 2022

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Jonathan M Goodwin, Ward G Walkup, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Mark R Chance

Sci Adv· October 2021

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New high-throughput endstation to accelerate the experimental optimization pipeline for synchrotron X-ray footprinting.
Rohit Jain, Donald Abel, Maksim Rakitin, Michael Sullivan, David T Lodowski, Mark R Chance

J Synchrotron Radiat· September 2021

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Structurally distinct external solvent-exposed domains drive replication of major human prions.
Mohammad Khursheed Siddiqi, Chae Kim, Tracy Haldiman, Miroslava Kacirova, Benlian Wang, Mark R Chance

PLoS Pathog· June 2021

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