Publications by authors named "Mark Chappell"

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Attenuated renin response and reduced angiotensin II concentrations: association with cardiopulmonary bypass-induced vasoplegia.
Bartlomiej R Imielski, Ashish K Khanna, Spencer Tingey, Christopher L Schaich, Kendra N Wright, Mark C Chappell

Br J Anaesth· December 2025

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Association between plasma catecholamine concentration and mortality in hospitalized adults with COVID-19: a secondary analysis of a multicenter randomized trial.
Basmah Safdar, Gary Desir, Bin Zhou, Yanhong Deng, Xiaojia Guo, Mark C Chappell

Crit Care· May 2025

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Multi-disciplinary investigation identifies increased potency of ethyl-parathion inhaled within a soil-dust matrix to cause acetylcholinesterase-dependent molecular impacts.
Kurt A Gust, Saroj K Amar, Chet P Gut, Renee M Styles, Ranju R Karna, Mark A Chappell

Environ Toxicol Pharmacol· March 2025

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The circulating renin-angiotensin system and mortality among patients hospitalized for COVID-19: a mechanistic substudy of the ACTIV-4 Host Tissue trials.
Christopher L Schaich, Mark C Chappell, Matthew S Shotwell, Meghan M Joly, Kevin W Gibbs

Am J Physiol Lung Cell Mol Physiol· March 2025

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Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients.
Mark C Chappell, Christopher L Schaich, Laurence W Busse, D Clark Files, Greg S Martin

Clin Sci (Lond)· January 2025

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Geochemical exploration of rare earth element resources in highland karstic bauxite deposits in the Sierra de Bahoruco, Pedernales Province, Southwestern Dominican Republic.
Mark Chappell, Harold Rojas, Charles Andros, Autumn Acree, Yoko Masue-Slowey

PLoS One· January 2025

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Reply to: angiotensinogen: a new era beyond lactate as a biomarker?
Mark C Chappell, Christopher L Schaich, Ashish K Khanna

Crit Care· December 2024

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Angiotensin Converting Enzyme Hub Model of Peptide Flux Relating Calculated AT1 Receptor and Aldosterone Levels.
Brian M Westwood, Mark C Chappell

bioRxiv· December 2024

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Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial.
Mark C Chappell, Christopher L Schaich, Laurence W Busse, Greg S Martin, Jonathan E Sevransky

Crit Care· October 2024

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Dysfunction of the renin-angiotensin-aldosterone system in human septic shock.
Christopher L Schaich, Daniel E Leisman, Marcia B Goldberg, Micheal R Filbin, Ashish K Khanna, Mark C Chappell

Peptides· June 2024

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The role of preterm birth in stress-induced sodium excretion in young adults.
Nicholas W Tully, Mark C Chappell, Joni K Evans, Elizabeth T Jensen, Hossam A Shaltout

J Hypertens· June 2024

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Renin in critically ill patients.
Yuki Kotani, Mark Chappell, Giovanni Landoni, Alexander Zarbock, Rinaldo Bellomo

Ann Intensive Care· May 2024

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ACE inhibitors and angiotensin receptor blockers differentially alter the response to angiotensin II treatment in vasodilatory shock.
Daniel E Leisman, Damian R Handisides, Laurence W Busse, Mark C Chappell, Lakhmir S Chawla

Crit Care· April 2024

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Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial.
Laurence W Busse, Christopher L Schaich, Mark C Chappell, Michael T McCurdy, Erin M Staples

Crit Care Med· March 2024

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Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment.
Mark C Chappell

Circ Res· May 2023

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Discrete Correlation Summation Clustering Reveals Differential Regulation of Liver Metabolism by Thrombospondin-1 in Low-Fat and High-Fat Diet-Fed Mice.
Steven M Bronson, Brian Westwood, Katherine L Cook, Nancy J Emenaker, Mark C Chappell

Metabolites· October 2022

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Targeted UHPLC-MS Analysis Reveals Disparate Polyphenol Composition and Concentration in Muscadine Grape Supplements with Proportional Antioxidant Activity.
Mark C Chappell, Aja V Duncan, Ana Clara Melo, Christopher L Schaich, Nancy T Pirro

Antioxidants (Basel)· October 2022

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Angiotensinogen uptake and stimulation of oxidative stress in human pigment retinal epithelial cells.
Victor M Pulgar, Nildris Cruz-Diaz, Brian M Westwood, Mark C Chappell

Peptides· June 2022

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The Renin-Angiotensin-Aldosterone System in COVID-19-related and Non-COVID-19-related Acute Respiratory Distress Syndrome: Not So Different after All?
Sean P Collins, Mark C Chappell, D Clark Files

Am J Respir Crit Care Med· November 2021

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Gut dysbiosis and hypertension: is it cause or effect?
Katherine L Cook, Mark C Chappell

J Hypertens· September 2021

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Metabolic rates of aggressive and submissive phenotypes are colour blind in the polymorphic Gouldian finch.
William A Buttemer, Vincent Careau, Mark A Chappell, Simon C Griffith

J Exp Biol· August 2021

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A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure.
D Clark Files, Kevin W Gibbs, Christopher L Schaich, Sean P Collins, TanYa M Gwathmey, Mark C Chappell

Am J Physiol Lung Cell Mol Physiol· July 2021

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Phase I Study of Muscadine Grape Extract for Patients With Advanced Cancer.
Rhonda L Bitting, Janet A Tooze, Scott Isom, W Jeffrey Petty, Stefan C Grant, Mark C Chappell

Am J Clin Oncol· June 2021

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A test of altitude-related variation in aerobic metabolism of Andean birds.
Natalia Gutierrez-Pinto, Gustavo A Londoño, Mark A Chappell, Jay F Storz

J Exp Biol· June 2021

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Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.
Tiffany M Newman, Carol A Shively, Thomas C Register, Susan E Appt, Hariom Yadav, Mark C Chappell

Microbiome· May 2021

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