Publications by authors named "Mark D Distefano"

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Profiling of C-terminal prenylated proteins using tandem mass tagging.
Harinarayanan Kottala, Yuanzhe Chen, Mark D Distefano

Methods Enzymol· September 2025

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Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome.
Alexandru M Petre, Josslen S Thieschafer, Charuta Palsuledesai, Katie Cornille, Allison Chang, Mark D Distefano

ACS Chem Biol· August 2025

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Engineering protein prenylation: an emerging tool for selective protein modification.
Sneha Venkatachalapathy, Caitlin Lichtenfels, Carston R Wagner, Mark D Distefano

Biochem Soc Trans· August 2025

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An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis.
Shelby A Auger, Jodi S Pedersen, Sanjay Maity, Andrea M Sprague-Getsy, Ellen L Lorimer, Mark D Distefano

Biochemistry· January 2025

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The utility of Streptococcus mutans undecaprenol kinase for the chemoenzymatic synthesis of diverse non-natural isoprenoids.
Vikas Kumar, Bryce P Johnson, Prashant S Mandal, Daniel R Sheffield, Dustin A Dimas, Mark D Distefano

Bioorg Chem· October 2024

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Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry.
Shelby A Auger, Sneha Venkatachalapathy, Kiall Francis G Suazo, Yiao Wang, Alexander W Sarkis, Mark D Distefano

Bioconjug Chem· July 2024

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Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate.
Steven A Krauklis, Jamal Hussain, Katherine M Murphy, Evan L Dray, Carey G Ousley, Mark D Distefano

Am J Physiol Endocrinol Metab· July 2024

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Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors.
Kiall F Suazo, Vartika Mishra, Sanjay Maity, Shelby A Auger, Katarzyna Justyna, Mark D Distefano

Bioorg Chem· June 2024

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Targeted Drug Delivery by MMAE Farnesyl-Bioconjugated Multivalent Chemically Self-Assembled Nanorings Induces Potent Receptor-Dependent Immunogenic Cell Death.
Yiao Wang, Ozgun Kilic, Lakmal Rozumalski, Mark D Distefano, Carston R Wagner

Bioconjug Chem· May 2024

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Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase.
Garrett L Schey, Emily R Hildebrandt, You Wang, Safwan Diwan, Holly A Passetti, Mark D Distefano

Int J Mol Sci· May 2024

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Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors.
Kiall F Suazo, Vartika Mishra, Sanjay Maity, Shelby A Auger, Katarzyna Justyna, Mark D Distefano

bioRxiv· March 2024

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Multivalent Fluorinated Nanorings for On-Cell F NMR.
Jiaqian Li, Yiao Wang, Mark D Distefano, Carston R Wagner, William C K Pomerantz

Biomacromolecules· February 2024

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Facile immobilization of pyridoxal 5'-phosphate using p-diazobenzoyl-derivatized Sepharose 4B.
Kun-Hwa Lee, Mark D Distefano, Burckhard Seelig

Results Chem· December 2023

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Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1.
Kiall F Suazo, Jakub Bělíček, Garrett L Schey, Shelby A Auger, Alexandru M Petre, Mark D Distefano

RSC Chem Biol· November 2023

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Orthogonal Enzyme-Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates.
Robbins Puthenveetil, Shelby A Auger, Natalia Gómez-Navarro, Mitra Shumsher Rana, Riki Das, Mark D Distefano

J Am Chem Soc· October 2023

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Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues.
Katarzyna Justyna, Riki Das, Ellen L Lorimer, Jiayue Hu, Jodi S Pedersen, Mark D Distefano

Org Lett· September 2023

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GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS.
Olivia J Koehn, Ellen Lorimer, Bethany Unger, Ra'Mal Harris, Akansha S Das, Mark D Distefano

J Biol Chem· June 2023

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Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities.
Anastasiia Petenkova, Shelby A Auger, Jeffrey Lamb, Daisy Quellier, Cody Carter, Mark D Distefano

Nat Commun· May 2023

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Photoresponsive Hydrogels for Studying Mechanotransduction of Cells.
Keun-Young Park, David J Odde, Mark D Distefano

Methods Mol Biol· January 2023

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Engineering Biomimetic Trogocytosis with Farnesylated Chemically Self-Assembled Nanorings.
Yiao Wang, Lakmal Rozumalski, Ozgun Kilic, Caitlin Lichtenfels, Jacob Petersberg, Mark D Distefano

Biomacromolecules· December 2022

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Manipulating Cell Fates with Protein Conjugates.
Yiao Wang, Carston R Wagner, Mark D Distefano

Bioconjug Chem· October 2022

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Prenylomic Profiling in the Brain of a Transgenic Mouse Model of Alzheimer's Disease Reveals Increased Prenylation of a Key Set of Proteins.
Angela Jeong, Shelby A Auger, Sanjay Maity, Kristina Fredriksen, Rui Zhong, Mark D Distefano

ACS Chem Biol· October 2022

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Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation.
Johannes Morstein, Taysir Bader, Ariana L Cardillo, Julian Schackmann, Sudhat Ashok, Mark D Distefano

ACS Chem Biol· October 2022

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Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
You Wang, Feng Xu, Connie B Nichols, Yuqian Shi, Homme W Hellinga, Mark D Distefano

J Med Chem· October 2022

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Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy.
Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Mark D Distefano

Int J Mol Sci· September 2022

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