Publications by authors named "Mark D Long"

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Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate.
Hiroki Ozawa, Kazuki Takahashi, Tomoki Motegi, Justine Jacobi, Atrayee Bhattarchya, Mark D Long

Clin Cancer Res· December 2025

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IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunity.
Yihan Zuo, David J Vohwinkel, Bowen Dong, James R McDowell, Brandon V Guzman, Mark D Long

Cancer Cell· December 2025

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Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma.
Nicholas J Salgia, Adil Khan, Wilhelm M Aubrecht, Gavin C Twoey, Jacky Chow, Mark D Long

Cancer Cell· November 2025

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EZH2 Suppression Diversifies Prostate Cancer Lineage Variant Evolution and Lacks Efficacy in Inhibiting Disease Progression.
Justine J Jacobi, Kristine M Wadosky, Neha Jaiswal, Xiaojing Zhang, Yanqing Wang, Mark D Long, Henry W Long

Cancer Res· November 2025

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MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progression.
Hiroki Ozawa, Yin Wang, Henry G Withers, Naoki Haratake, Ayako Nakashoji, Mark D Long

Oncogene· October 2025

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HNF1A is a novel BRD4 target and critical for BET-inhibitor response in pancreatic ductal adenocarcinoma.
Kennedy S Humphrey, Katherine J Crawford, Bharani Muppavarapu, Melanie M Mayberry, William Morris, Mark D Long

bioRxiv· October 2025

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BiTE-secreting T cells rationally combine with PD-1 blockade and vaccine boosting to reshape antitumor immunity in ovarian cancer.
Jessie L Chiello, Nijamuddin Shaikh, Justine Jacobi, Nicole Gaulin, Gabriel Santos, Mark D Long

Mol Ther· September 2025

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MUC1-C dependence in treatment-resistant prostate cancer uncovers a target for antibody-drug conjugate therapy.
Keisuke Shigeta, Tatsuaki Daimon, Hiroshi Hongo, Sheng-Yu Ku, Hiroki Ozawa, Mark D Long

JCI Insight· July 2025

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Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma.
Katherine J Crawford, Kennedy S Humphrey, Eduardo Cortes, Jianxin Wang, Vishnu Kumarasamy, Mark D Long

Mol Cancer· July 2025

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Associations of DNA methylation in breast tumour subtypes with parity and breastfeeding in a cohort of 1459 Black women: implications for public health.
Christine B Ambrosone, Song Yao, Mark D Long, Chunyu Liu, Jianhong Chen

BMJ Oncol· March 2025

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Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy.
Ryutaro Kajihara, Mark D Long, Toshifumi Hoki, Hongbin Chen, Takayoshi Yamauchi

J Immunother Cancer· January 2025

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Integrative multi-omics analysis uncovers tumor-immune-gut axis influencing immunotherapy outcomes in ovarian cancer.
Spencer R Rosario, Mark D Long, Shanmuga Chilakapati, Eduardo Cortes Gomez, Sebastiano Battaglia

Nat Commun· December 2024

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Stratification of Patients with Renal Cell Carcinoma by the Abundance of Sarcomatoid Features Reveals Differences in Survival and the Underlying Pathobiology.
Nicholas J Salgia, Wilhelm M Aubrecht, Lin Wang, Bebu Ram, Brianna J Wasik, Mark D Long

Eur Urol Oncol· October 2024

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NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs.
Bowen Dong, Nataša Obermajer, Takemasa Tsuji, Junko Matsuzaki, Cindy M Bonura, Mark D Long

Cancer Immunol Res· October 2024

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Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma.
Hirohito Ishigaki, Takayoshi Yamauchi, Mark D Long, Toshifumi Hoki, Yuta Yamamoto

Cancer Res Commun· July 2024

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Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer.
Sheng-Yu Ku, Yanqing Wang, Maria Mica Garcia, Yasutaka Yamada, Kei Mizuno, Mark D Long

J Clin Invest· July 2024

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A Senescence-Mimicking (Senomimetic) VEGFR TKI Side Effect Primes Tumor Immune Responses via IFN/STING Signaling.
Melissa Dolan, Yuhao Shi, Michalis Mastri, Mark D Long, Amber McKenery

Mol Cancer Ther· June 2024

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The predominant Quillaja Saponaria fraction, QS-18, is safe and effective when formulated in a liposomal murine cancer peptide vaccine.
Shiqi Zhou, Yiting Song, Anoop Nilam, Yuan Luo, Wei-Chiao Huang, Mark D Long

J Control Release· May 2024

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Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.
Ayako Nakashoji, Naoki Haratake, Atrayee Bhattacharya, Weipu Mao, Kangjie Xu, Mark D Long

Cancer Res Commun· May 2024

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A senescence-mimicking (senomimetic) VEGFR TKI side-effect primes tumor immune responses via IFN/STING signaling.
Melissa Dolan, Yuhao Shi, Michalis Mastri, Mark D Long, Amber McKenery

Mol Cancer Ther· May 2024

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Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen.
Shiqi Zhou, Yiting Song, Yuan Luo, Breandan Quinn, Yang Jiao, Mark D Long

Cancer Res Commun· April 2024

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Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency.
Patrick A Flynn, Mark D Long, Yoko Kosaka, Nicola Long, Jessica S Mulkey

Front Immunol· March 2024

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Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer.
Sajad A Wani, Shahid Hussain, Jaimie S Gray, Debasis Nayak, Hancong Tang, Mark D Long

bioRxiv· February 2024

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Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.
Takaaki Oba, Mark D Long, Ken-Ichi Ito, Fumito Ito

Sci Rep· January 2024

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Aryl hydrocarbon receptor is a tumor promoter in -amplified neuroblastoma cells through suppression of differentiation.
Kanita A Chaudhry, Justine J Jacobi, Bryan M Gillard, Ellen Karasik, Jeffrey C Martin, Mark D Long

iScience· November 2023

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