Publications by authors named "Mark D Szczelkun"

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Structure and activation mechanism of a Lamassu phage and plasmid defense system.
Yan Li, David W Adams, Hon Wing Liu, Steven J Shaw, Emiko Uchikawa, Mark D Szczelkun

Nat Struct Mol Biol· December 2025

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Various plasmid strategies limit the effect of bacterial restriction-modification systems against conjugation.
Tatiana Dimitriu, Mark D Szczelkun, Edze R Westra

Nucleic Acids Res· November 2024

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The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape.
Alice Maestri, Benoit J Pons, Elizabeth Pursey, Charlotte E Chong, Sylvain Gandon, Mark D Szczelkun

Cell Host Microbe· August 2024

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Short-range translocation by a restriction enzyme motor triggers diffusion along DNA.
Martin Göse, Emma E Magill, Alex Hughes-Games, Steven J Shaw, Fiona M Diffin, Mark D Szczelkun

Nat Chem Biol· June 2024

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Multi-layered genome defences in bacteria.
Aleksei Agapov, Kate S Baker, Paritosh Bedekar, Rama P Bhatia, Tim R Blower, Mark D Szczelkun

Curr Opin Microbiol· April 2024

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CRISPR-Cas12a-mediated DNA clamping triggers target-strand cleavage.
Mohsin M Naqvi, Laura Lee, Oscar E Torres Montaguth, Fiona M Diffin, Mark D Szczelkun

Nat Chem Biol· September 2022

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Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition.
Tatiana Dimitriu, Elena Kurilovich, Urszula Łapińska, Konstantin Severinov, Stefano Pagliara, Mark D Szczelkun

Cell Host Microbe· January 2022

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ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing.
Oscar E Torres Montaguth, Stephen J Cross, Kincaid W A Ingram, Laura Lee, Fiona M Diffin, Mark D Szczelkun

Nucleic Acids Res· November 2021

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Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems.
Tatiana Dimitriu, Mark D Szczelkun, Edze R Westra

Curr Biol· October 2020

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Mitochondrial import, health and mtDNA copy number variability seen when using type II and type V CRISPR effectors.
Zuriñe Antón, Grace Mullally, Holly C Ford, Marc W van der Kamp, Mark D Szczelkun

J Cell Sci· September 2020

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5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage.
Grace Mullally, Kara van Aelst, Mohsin M Naqvi, Fiona M Diffin, Tautvydas Karvelis, Mark D Szczelkun

Nucleic Acids Res· July 2020

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Characterization of the Type III restriction endonuclease PstII from Providencia stuartii.
Alice Sears, Luke J Peakman, Geoffrey G Wilson, Mark D Szczelkun

Nucleic Acids Res· December 2019

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The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a.
Kara van Aelst, Carlos J Martínez-Santiago, Stephen J Cross, Mark D Szczelkun

Genes (Basel)· February 2019

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Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity.
Neha Nirwan, Pratima Singh, Gyana Gourab Mishra, Christopher M Johnson, Mark D Szczelkun

Nucleic Acids Res· January 2019

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The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor.
Paulius Toliusis, Giedre Tamulaitiene, Rokas Grigaitis, Donata Tuminauskaite, Arunas Silanskas, Mark D Szczelkun

Nucleic Acids Res· March 2018

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CgII cleaves DNA using a mechanism distinct from other ATP-dependent restriction endonucleases.
Paulius Toliusis, Mindaugas Zaremba, Arunas Silanskas, Mark D Szczelkun, Virginijus Siksnys

Nucleic Acids Res· August 2017

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Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity.
Benedict G Tan, Frederick C Wellesley, Nigel J Savery, Mark D Szczelkun

Nucleic Acids Res· September 2016

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Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes.
Manasi Kulkarni, Neha Nirwan, Kara van Aelst, Mark D Szczelkun, Kayarat Saikrishnan

Nucleic Acids Res· May 2016

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Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations.
Kara van Aelst, Kayarat Saikrishnan, Mark D Szczelkun

Nucleic Acids Res· December 2015

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Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes.
Júlia Tóth, Jack Bollins, Mark D Szczelkun

Nucleic Acids Res· December 2015

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Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes.
Mahesh K Chand, Neha Nirwan, Fiona M Diffin, Kara van Aelst, Manasi Kulkarni, Mark D Szczelkun

Nat Chem Biol· November 2015

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DNA cleavage by CgII and NgoAVII requires interaction between N- and R-proteins and extensive nucleotide hydrolysis.
Mindaugas Zaremba, Paulius Toliusis, Rokas Grigaitis, Elena Manakova, Arunas Silanskas, Mark D Szczelkun

Nucleic Acids Res· December 2014

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ClpXP protease targets long-lived DNA translocation states of a helicase-like motor to cause restriction alleviation.
Michelle Simons, Fiona M Diffin, Mark D Szczelkun

Nucleic Acids Res· October 2014

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.
Mark D Szczelkun, Maria S Tikhomirova, Tomas Sinkunas, Giedrius Gasiunas, Tautvydas Karvelis

Proc Natl Acad Sci U S A· July 2014

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Type III restriction endonucleases are heterotrimeric: comprising one helicase-nuclease subunit and a dimeric methyltransferase that binds only one specific DNA.
Annika Butterer, Christian Pernstich, Rachel M Smith, Frank Sobott, Mark D Szczelkun

Nucleic Acids Res· April 2014

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