Publications by authors named "Mark Erion"

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Pan AMPK activation protects tubules in rat ischemic acute kidney injury.
Henriette Frikke-Schmidt, Kamal Albarazanji, Jenson Qi, David Frederick, Janos Steffen, Mark Erion

J Pharmacol Exp Ther· February 2025

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Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD.
Elisa Fabbrini, Brian Rady, Anastasiya Koshkina, Jae Yoon Jeon, Vivaswath S Ayyar, Mark Erion

N Engl J Med· August 2024

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Author Correction: Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mark D Erion

Nat Commun· January 2024

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The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR.
Janos Steffen, Jennifer Ngo, Sheng-Ping Wang, Kevin Williams, Henning F Kramer, Mark Erion

Mol Metab· October 2022

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Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes.
Anandan Palani, Andrea R Nawrocki, Federica Orvieto, Elisabetta Bianchi, Emanuela Mandić, Mark Erion

ACS Med Chem Lett· August 2022

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Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.
Dmitri A Pissarnitski, Ahmet Kekec, Lin Yan, Yuping Zhu, Danqing D Feng, Mark D Erion

J Med Chem· April 2022

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Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mark D Erion

Nat Commun· February 2022

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PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells.
Brian Rady, Takahiro Nishio, Debanjan Dhar, Xiao Liu, Mark Erion

PLoS One· January 2022

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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Mark D Erion

PLoS One· December 2019

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Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Bhagirath Chaurasia, Trevor S Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Mark D Erion

Science· July 2019

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A Long-Acting PYY Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.
Shamina M Rangwala, Katharine D'Aquino, Yue-Mei Zhang, Lindsay Bader, Wilson Edwards, Mark D Erion

Cell Metab· April 2019

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Using [H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies.
Stephen F Previs, Kithsiri Herath, Andrea R Nawrocki, Carlos G Rodriguez, Deborah Slipetz, Mark D Erion

Am J Physiol Endocrinol Metab· July 2018

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GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia.
Nina Xiaoyan Li, Stacey Brown, Tim Kowalski, Margaret Wu, Liming Yang, Mark Erion

Diabetes· July 2018

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Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299-308.
Niels C Kaarsholm, Songnian Lin, Lin Yan, Theresa Kelly, Margaret van Heek, Mark Erion

Diabetes· May 2018

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Engineering Glucose Responsiveness Into Insulin.
Niels C Kaarsholm, Songnian Lin, Lin Yan, Theresa Kelly, Margaret van Heek, Mark Erion

Diabetes· February 2018

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A glucose-responsive insulin therapy protects animals against hypoglycemia.
Ruojing Yang, Margaret Wu, Songnian Lin, Ravi P Nargund, Xinghai Li, Mark D Erion

JCI Insight· January 2018

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Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.
Natalie A Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G McLaren, Mark D Erion

J Pharmacol Exp Ther· October 2017

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GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.
Santhosh Satapati, Ying Qian, Margaret S Wu, Aleksandr Petrov, Ge Dai, Mark Erion

J Lipid Res· August 2017

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Mark D Erion

Science· August 2017

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Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.
Jin Shang, Stephen F Previs, Stacey Conarello, Keefe Chng, Yonghua Zhu, Mark Erion

Am J Physiol Endocrinol Metab· April 2017

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Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
Xinkang Wang, Stan Kurowski, Weizhen Wu, Gino A Castriota, Xueping Zhou, Mark Erion

J Pharmacol Exp Ther· March 2017

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Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.
Sheng-Ping Wang, Dan Zhou, Zuliang Yao, Santhosh Satapati, Ying Chen, Mark D Erion

Am J Physiol Endocrinol Metab· December 2016

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Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.
Xiaodong Yang, John Mudgett, Ghina Bou-About, Marie-France Champy, Hugues Jacobs, Mark D Erion

J Biol Chem· November 2016

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Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice.
Jin Shang, Jose M Castro-Perez, Xiaolan Shen, Yonghua Zhu, Haiying Liu, Mark Erion

Obesity (Silver Spring)· September 2016

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Glucagon receptor antagonism induces increased cholesterol absorption.
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M Castro-Perez, Mark D Erion

J Lipid Res· November 2015

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