Publications by authors named "Mark Holbrook"

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Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™.
Will S Redfern, Chris E Pollard, Mark Holbrook, Barira Islam, Mitra Abbasi

J Pharmacol Toxicol Methods· February 2025

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Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency - Role of physiological and other non-drug related parameters.
Barbara Wiśniowska, Mark Holbrook, Christopher Pollard, Sebastian Polak

J Clin Pharm Ther· December 2022

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Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents.
Helen Prior, Mark Holbrook

J Pharmacol Toxicol Methods· November 2021

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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Annie Delaunois, Matthew Abernathy, Warren D Anderson, Kylie A Beattie, Khuram W Chaudhary, Mark Holbrook

Clin Transl Sci· May 2021

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Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Helen Prior, Paul Baldrick, Sonja Beken, Helen Booler, Nancy Bower, Mark Holbrook

Regul Toxicol Pharmacol· June 2020

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General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Zhihua Li, Gary R Mirams, Takashi Yoshinaga, Bradley J Ridder, Xiaomei Han, Mark Holbrook

Clin Pharmacol Ther· January 2020

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Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development.
Sebastian Polak, Zofia Tylutki, Mark Holbrook, Barbara Wiśniowska

Drug Discov Today· July 2019

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Measurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys.
Marc O Niehoff, Birgit Niggemann, Jan Sternberg, Angela Jenkins, Mark Holbrook

J Pharmacol Toxicol Methods· September 2015

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Safety pharmacology investigations in toxicology studies: an industry survey.
Simon Authier, Hugo M Vargas, Michael J Curtis, Mark Holbrook, Michael K Pugsley

J Pharmacol Toxicol Methods· February 2014

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Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys.
Kenny J Watson, William P Gorczyca, John Umland, Ying Zhang, Xian Chen, Mark Holbrook

J Pharmacol Toxicol Methods· August 2011

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Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.
Mark D Andrews, Paul V Fish, Julian Blagg, Tiffini K Brabham, Paul E Brennan, Mark Holbrook

Bioorg Med Chem Lett· May 2011

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Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development?
Mark Holbrook, Marek Malik, Rashmi R Shah, Jean-Pierre Valentin

J Pharmacol Toxicol Methods· March 2009

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Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?
William S Redfern, Gareth Waldron, Matthew J Winter, Paul Butler, Mark Holbrook

J Pharmacol Toxicol Methods· January 2009

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The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD.
Alan D Brown, Mark E Bunnage, Paul A Glossop, Mark Holbrook, Rhys D Jones

Bioorg Med Chem Lett· November 2007

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The molecular cloning and functional expression of the dog CCR5.
Michael Mosley, Sarah Pullen, Andrew Botham, Andrew Gray, Carolyn Napier, Mark Holbrook

Vet Immunol Immunopathol· October 2006

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Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.
Carolyn Napier, Harriet Sale, Michael Mosley, Graham Rickett, Pat Dorr, Mark Holbrook

Biochem Pharmacol· December 2005

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Erythromycin slows aging of Saccharomyces cerevisiae.
Mark A Holbrook, John R Menninger

J Gerontol A Biol Sci Med Sci· January 2002

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