Publications by authors named "Mark Irvine"

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Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.
Kiran Sapkota, Erica S Burnell, Mark W Irvine, Guangyu Fang, Dinesh Y Gawande

Neuropharmacology· December 2021

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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.
Jue Xiang Wang, Mark W Irvine, Erica S Burnell, Kiran Sapkota, Robert J Thatcher

Nat Commun· January 2020

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Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid.
Mark W Irvine, Guangyu Fang, Kiran Sapkota, Erica S Burnell, Arturas Volianskis

Eur J Med Chem· February 2019

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Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.
Erica S Burnell, Mark Irvine, Guangyu Fang, Kiran Sapkota, David E Jane

J Med Chem· January 2019

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The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.
Kiran Sapkota, Kim Dore, Kang Tang, Mark Irvine, Guangyu Fang

Biochem Pharmacol· January 2019

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Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.
Kiran Sapkota, Mark W Irvine, Guangyu Fang, Erica S Burnell, Neil Bannister

Neuropharmacology· October 2017

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A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.
Divyan A Chopra, Kiran Sapkota, Mark W Irvine, Guangyu Fang, David E Jane

Sci Rep· July 2017

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The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site.
Fatemah Safar, Elliot Hurdiss, Marios Erotocritou, Timo Greiner, Remigijus Lape, Mark W Irvine

J Biol Chem· March 2017

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Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
Grace France, Diego Fernández-Fernández, Erica S Burnell, Mark W Irvine, Daniel T Monaghan

Neuropharmacology· January 2017

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An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.
James L Wallis, Mark W Irvine, David E Jane, David Lodge, Graham L Collingridge

Hippocampus· November 2015

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Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.
Mark W Irvine, Guangyu Fang, Richard Eaves, Maria B Mayo-Martin, Erica S Burnell

Synthesis (Stuttg)· June 2015

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Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.
Arturas Volianskis, Neil Bannister, Valerie J Collett, Mark W Irvine, Daniel T Monaghan

J Physiol· February 2013

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The NMDA receptor as a target for cognitive enhancement.
Graham L Collingridge, Arturas Volianskis, Neil Bannister, Grace France, Lydia Hanna, Mark W Irvine

Neuropharmacology· January 2013

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Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors.
Mark W Irvine, Blaise M Costa, Arturas Volianskis, Guangyu Fang, Laura Ceolin

Neurochem Int· September 2012

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Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.
Daniel T Monaghan, Mark W Irvine, Blaise Mathias Costa, Guangyu Fang, David E Jane

Neurochem Int· September 2012

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Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.
Blaise Mathias Costa, Mark W Irvine, Guangyu Fang, Richard J Eaves, Maria Belen Mayo-Martin

Neuropharmacology· March 2012

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Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.
Mark W Irvine, Blaise M Costa, Daniel Dlaboga, Georgia R Culley, Richard Hulse

J Med Chem· January 2012

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A novel family of negative and positive allosteric modulators of NMDA receptors.
Blaise Mathias Costa, Mark W Irvine, Guangyu Fang, Richard J Eaves, Marie Belen Mayo-Martin

J Pharmacol Exp Ther· December 2010

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N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.
Blaise Mathias Costa, Bihua Feng, Timur S Tsintsadze, Richard M Morley, Mark W Irvine

J Pharmacol Exp Ther· November 2009

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Rhodanine derivatives as novel inhibitors of PDE4.
Mark W Irvine, Graham L Patrick, Justin Kewney, Stuart F Hastings, Simon J MacKenzie

Bioorg Med Chem Lett· March 2008

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