Publications by authors named "Mark LeSage"

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Transcriptional signatures in the rat medial prefrontal cortex associated with vulnerability and resilience across distinct phases of opioid use disorder.
Shirelle X Liu, Peter Muelken, Zia L Maxim, Aarthi Ramakrishnan, Molly S Estill, Mark G LeSage

bioRxiv· August 2025

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Effects of volatile organic compounds found in cigarette smoke on intracranial self-stimulation in rats.
Andrew C Harris, Peter Muelken, Sam Howard, Sarah Wilde, Mark G LeSage

Drug Alcohol Depend· June 2025

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Magnitude and predictors of elasticity of demand for morphine are similar in male and female rats.
Andrew C Harris, Peter Muelken, Shirelle X Liu, John R Smethells, Mark G LeSage

Front Behav Neurosci· August 2024

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Substitutability of nicotine and sucrose in rats: A behavioral economic analysis.
Patricia E Bunney, John R Smethells, Mark G LeSage

Pharmacol Biochem Behav· November 2023

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A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models.
Bethany Crouse, Shannon M Miller, Peter Muelken, Linda Hicks, Jennifer R Vigliaturo, Mark G LeSage

NPJ Vaccines· July 2023

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The relative reinforcing efficacy of nicotine in an adolescent rat model of attention-deficit hyperactivity disorder.
John R Smethells, Danielle Burroughs, Amy Saykao, Mark G LeSage

Front Psychiatry· May 2023

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Stimulus functions of nicotine.
Mark G LeSage

Adv Pharmacol· May 2022

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Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats.
Andrew C Harris, Peter Muelken, Aleksandra Alcheva, Irina Stepanov, Mark G LeSage

Front Neurosci· May 2022

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Attenuating nicotine's effects with high affinity human anti-nicotine monoclonal antibodies.
Michael D Raleigh, Nicola Beltraminelli, Stephanie Fallot, Mark G LeSage, Amy Saykao

PLoS One· November 2021

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The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.
John R Smethells, Danielle Burroughs, Amy Saykao, Paul R Pentel, Amir H Rezvani, Mark G LeSage

Drug Alcohol Depend· February 2021

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Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity.
Christine Robinson, Valeria Gradinati, Fatima Hamid, Carly Baehr, Bethany Crouse, Mark LeSage

J Med Chem· December 2020

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β-Carbolines found in cigarette smoke elevate intracranial self-stimulation thresholds in rats.
Andrew C Harris, Peter Muelken, Mark G LeSage

Pharmacol Biochem Behav· November 2020

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Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.
Yayi Swain, Peter Muelken, Annika Skansberg, Danielle Lanzdorf, Zachary Haave, Mark G LeSage

Psychopharmacology (Berl)· August 2020

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Comparison of the Relative Abuse Liability of Electronic Cigarette Aerosol Extracts and Nicotine Alone in Adolescent Rats: A Behavioral Economic Analysis.
Andrew C Harris, John R Smethells, Mary Palumbo, Maciej Goniewicz, Mark G LeSage

Int J Environ Res Public Health· January 2020

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Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats.
Andrew C Harris, Peter Muelken, Yayi Swain, Mary Palumbo, Vipin Jain, Mark G LeSage

Drug Alcohol Depend· October 2019

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Propylene glycol, a major electronic cigarette constituent, attenuates the adverse effects of high-dose nicotine as measured by intracranial self-stimulation in rats.
Andrew C Harris, Peter Muelken, Zach Haave, Yayi Swain, John R Smethells, Mark G LeSage

Drug Alcohol Depend· December 2018

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Consortium on Methods Evaluating Tobacco: Research Tools to Inform US Food and Drug Administration Regulation of Snus.
Micah L Berman, Warren K Bickel, Andrew C Harris, Mark G LeSage, Richard J O'Connor

Nicotine Tob Res· September 2018

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A Bayesian hierarchical model for demand curve analysis.
Yen-Yi Ho, Tien Nhu Vo, Haitao Chu, Mark G LeSage, Xianghua Luo

Stat Methods Med Res· August 2018

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Status and Future Directions of Preclinical Behavioral Pharmacology in Tobacco Regulatory Science.
Mark G LeSage, John R Smethells, Andrew C Harris

Behav Anal (Wash D C)· August 2018

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The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.
Paul R Pentel, Michael D Raleigh, Mark G LeSage, Thomas Thisted, Stephen Horrigan

BMC Biotechnol· July 2018

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Effects of nicotine-containing and "nicotine-free" e-cigarette refill liquids on intracranial self-stimulation in rats.
Andrew C Harris, Peter Muelken, John R Smethells, Katrina Yershova, Irina Stepanov, Mark G LeSage

Drug Alcohol Depend· April 2018

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Substitutability of nicotine alone and an electronic cigarette liquid using a concurrent choice assay in rats: A behavioral economic analysis.
John R Smethells, Andrew C Harris, Danielle Burroughs, Steven R Hursh, Mark G LeSage

Drug Alcohol Depend· April 2018

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Locomotor activity does not predict individual differences in morphine self-administration in rats.
Yayi Swain, Peter Muelken, Mark G LeSage, Jonathan C Gewirtz, Andrew C Harris

Pharmacol Biochem Behav· March 2018

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Effects of isolated tobacco alkaloids and tobacco products on deprivation-induced food intake and meal patterns in rats.
Patricia E Bunney, Mylissa Hansen, Mark LeSage

Pharmacol Biochem Behav· February 2018

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Self-Administration of Smokeless Tobacco Products in Rats.
Mark G LeSage, Danielle Burroughs, Peter Muelken, Andrew C Harris

Tob Regul Sci· October 2016

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