Publications by authors named "Mark Naples"

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Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.
Amir Bashiri, Dinushan Nesan, Ghazaleh Tavallaee, Ian Sue-Chue-Lam, Kevin Chien, Mark Naples

Biochim Biophys Acta· July 2016

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Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.
Shabana Amanda Ali, Mushriq Al-Jazrawe, Henry Ma, Heather Whetstone, Raymond Poon, Mark Naples

Arthritis Rheumatol· January 2016

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Central Nervous System Regulation of Intestinal Lipoprotein Metabolism by Glucagon-Like Peptide-1 via a Brain-Gut Axis.
Sarah Farr, Christopher Baker, Mark Naples, Jennifer Taher, Jahangir Iqbal

Arterioscler Thromb Vasc Biol· May 2015

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GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipogenesis in insulin resistance.
Jennifer Taher, Christopher L Baker, Carmelle Cuizon, Hassan Masoudpour, Rianna Zhang, Mark Naples

Mol Metab· December 2014

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Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis.
Qiaozhu Su, Chris Baker, Patricia Christian, Mark Naples, Xuedong Tong

Am J Physiol Endocrinol Metab· June 2014

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Hepatic cholesterol homeostasis: is the low-density lipoprotein pathway a regulatory or a shunt pathway?
Allan D Sniderman, Yanqin Qi, Cheng-I J Ma, Rui Hao Leo Wang, Mark Naples

Arterioscler Thromb Vasc Biol· November 2013

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Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.
Mark J Dekker, Chris Baker, Mark Naples, Josh Samsoondar, Rianna Zhang

Atherosclerosis· May 2013

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AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.
Stephen L Pinkosky, Sergey Filippov, Rai Ajit K Srivastava, Jeffrey C Hanselman, Cheryl D Bradshaw, Mark Naples

J Lipid Res· January 2013

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Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Lauren Hager, Lixin Li, Henry Pun, Lu Liu, Mohammad A Hossain, Mark Naples

J Biol Chem· June 2012

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Ezetimibe ameliorates intestinal chylomicron overproduction and improves glucose tolerance in a diet-induced hamster model of insulin resistance.
Mark Naples, Chris Baker, Marsel Lino, Jahangir Iqbal, M Mahmood Hussain

Am J Physiol Gastrointest Liver Physiol· May 2012

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Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats.
Jessica T Y Yue, Patricia I Mighiu, Mark Naples, Khosrow Adeli, Tony K T Lam

Circ Res· May 2012

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Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.
Sally Yu Shi, Rubén García Martin, Robin E Duncan, Diana Choi, Shun-Yan Lu, Mark Naples

J Biol Chem· March 2012

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C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases.
Liang Xi, Changting Xiao, Robert H J Bandsma, Mark Naples, Khosrow Adeli

Hepatology· January 2011

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Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Adam S Sirek, Ling Liu, Mark Naples, Khosrow Adeli, Dominic S Ng

Endocrinology· August 2009

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LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.
Heather Basciano, Abigale Miller, Chris Baker, Mark Naples, Khosrow Adeli

Am J Physiol Gastrointest Liver Physiol· August 2009

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Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.
Heather Basciano, Abigale E Miller, Mark Naples, Christopher Baker, Rita Kohen

Am J Physiol Endocrinol Metab· August 2009

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Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production.
Julie Tsai, Rianna Zhang, Wei Qiu, Qiaozhu Su, Mark Naples

Am J Physiol Gastrointest Liver Physiol· June 2009

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Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
Wei Qiu, Lisa Federico, Mark Naples, Rita Kohen Avramoglu, Reza Meshkani

Hepatology· December 2008

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Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: evidence for statin-induced hepatic insulin sensitization.
Mark Naples, Lisa M Federico, Elaine Xu, Joanna Nelken, Khosrow Adeli

Atherosclerosis· May 2008

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LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling.
Lixin Li, Mark Naples, Hui Song, Ronghua Yuan, Feilu Ye

Am J Physiol Endocrinol Metab· August 2007

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Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine.
Lisa M Federico, Mark Naples, Denise Taylor, Khosrow Adeli

Diabetes· May 2006

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Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia.
Taryne Chong, Mark Naples, Lisa Federico, Denise Taylor, Graham J Smith

Atherosclerosis· March 2006

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Oleate-mediated stimulation of microsomal triglyceride transfer protein (MTP) gene promoter: implications for hepatic MTP overexpression in insulin resistance.
Wei Qiu, Changiz Taghibiglou, Rita Kohen Avramoglu, Stephen C Van Iderstine, Mark Naples

Biochemistry· March 2005

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Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies.
Wei Qiu, Rita Kohen Avramoglu, Nadia Dubé, Taryne M Chong, Mark Naples

Diabetes· December 2004

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Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone.
Gary F Lewis, Susan Murdoch, Kristine Uffelman, Mark Naples, Linda Szeto

Diabetes· November 2004

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