Publications by authors named "Mark Noviski"

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Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
Daniel W Robbins, Mark A Noviski, Ying Siow Tan, Zef A Konst, Aileen Kelly

J Med Chem· February 2024

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Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Skye Montoya, Jessie Bourcier, Mark Noviski, Hao Lu, Meghan C Thompson

Science· February 2024

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NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.
Deyi Zhang, Hailey M Harris, Jonathan Chen, Jen Judy, Gabriella James, Mark Noviski

Blood· March 2023

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NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting.
Corey Tan, Ryosuke Hiwa, James L Mueller, Vivasvan Vykunta, Kenta Hibiya, Mark Noviski

Nat Immunol· October 2020

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Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance.
Corey Tan, Mark Noviski, John Huizar, Julie Zikherman

Immunol Rev· November 2019

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Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens.
Mark Noviski, Corey Tan, John Huizar, Vivasvan Vykunta, James L Mueller

J Immunol· July 2019

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Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
Corey Tan, James L Mueller, Mark Noviski, John Huizar, Denise Lau

J Immunol· May 2019

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Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance.
Mark Noviski, Julie Zikherman

Curr Opin Immunol· December 2018

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IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Mark Noviski, James L Mueller, Anne Satterthwaite, Lee Ann Garrett-Sinha, Frank Brombacher

Elife· March 2018

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Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells.
John Huizar, Corey Tan, Mark Noviski, James L Mueller, Julie Zikherman

Immunohorizons· November 2017

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An extracatalytic function of CD45 in B cells is mediated by CD22.
Sarah Coughlin, Mark Noviski, James L Mueller, Ammarina Chuwonpad, William C Raschke

Proc Natl Acad Sci U S A· November 2015

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