Publications by authors named "Mark P Hedger"

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Hidden diversity: Identification and characterisation of compartment-specific testicular macrophage populations.
Sneha Biniwale, Rukmali Wijayarathna, Rosemary Genovese, Christiane Pleuger, Vishnu Kumar, Mark P Hedger

J Reprod Immunol· December 2025

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Epididymitis promotes formation of tertiary lymphoid organs in the cauda epididymidis.
Hiba Hasan, Christiane Pleuger, Dingding Ai, Sudhanshu Bhushan, Eva Wahle, Mark P Hedger

Mucosal Immunol· December 2025

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Impact of Excess Activin A on the Lipids, Metabolites, and Steroids of Adult Mouse Reproductive Organs.
Jennifer C Hutchison, Paul J Trim, Penny A F Whiley, David J Handelsman, Marten F Snel, Mark P Hedger

Endocrinology· March 2025

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Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
Rukmali Wijayarathna, Eveline D de Geus, Rosemary Genovese, Linden J Gearing, Georgie Wray-McCann, Mark P Hedger

PLoS Pathog· December 2024

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New aspects of activin biology in epididymal function and immunopathology.
Rukmali Wijayarathna, Mark P Hedger

Andrology· July 2024

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Monocytes expressing activin A and CCR2 exacerbate chronic testicular inflammation by promoting immune cell infiltration.
Hiba Hasan, Wei Peng, Rukmali Wijayarathna, Eva Wahle, Daniela Fietz, Mark P Hedger

Hum Reprod· May 2024

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Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis.
Wei Peng, Artem Kepsch, Till O Kracht, Hiba Hasan, Rukmali Wijayarathna, Mark P Hedger

Cell Mol Life Sci· November 2022

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The changing landscape of immune cells in the fetal mouse testis.
Samira Hosseini, Sarah C Moody, Daniela Fietz, Sivanjah Indumathy, Hans-Christian Schuppe, Mark P Hedger

Histochem Cell Biol· October 2022

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Regulation of macrophage number and gene transcript levels by activin A and its binding protein, follistatin, in the testes of adult mice.
Sneha Biniwale, Rukmali Wijayarathna, Christiane Pleuger, Sudhanshu Bhushan, Kate L Loveland, Mark P Hedger

J Reprod Immunol· June 2022

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Examination of testicular lumicrine regulation of activins and immunoregulatory genes in the epididymal caput.
Rukmali Wijayarathna, Rosemary Genovese, Andreas Meinhardt, Kate L Loveland, Nigel P Groome, Mark P Hedger

Andrology· January 2022

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Experimental Cryptorchidism Causes Chronic Inflammation and a Progressive Decline in Sertoli Cell and Leydig Cell Function in the Adult Rat Testis.
Rashid A Aldahhan, Peter G Stanton, Helen Ludlow, David M de Kretser, Mark P Hedger

Reprod Sci· October 2021

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Region-specific immune responses to autoimmune epididymitis in the murine reproductive tract.
Rukmali Wijayarathna, Alen Pasalic, Nour Nicolas, Sneha Biniwale, Rama Ravinthiran, Mark P Hedger

Cell Tissue Res· August 2020

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Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse.
Britta Klein, Sudhanshu Bhushan, Stefan Günther, Ralf Middendorff, Kate L Loveland, Mark P Hedger

Mol Hum Reprod· April 2020

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Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes.
Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Mark P Hedger

FASEB J· April 2020

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Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis.
Rashid A Aldahhan, Peter G Stanton, Helen Ludlow, David M de Kretser, Mark P Hedger

Mol Cell Endocrinol· December 2019

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Pre-pubertal growth, muscle and fat accumulation in male and female sheep-Relationships with metabolic hormone concentrations, timing of puberty and reproductive outcomes.
Cesar A Rosales Nieto, Mark B Ferguson, Jan R Briegel, Mark P Hedger, Graeme B Martin

Reprod Domest Anim· December 2019

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Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis.
A Christine Kauerhof, Nour Nicolas, Sudhanshu Bhushan, Eva Wahle, Kate A Loveland, Mark P Hedger

Hum Reprod· August 2019

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Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model.
Britta Klein, Swapnila Pant, Sudhanshu Bhushan, Julia Kautz, Carsten Rudat, Mark P Hedger

Hum Reprod· July 2019

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Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro.
Dulama Richani, Katherine Constance, Shelly Lien, David Agapiou, William A Stocker, Mark P Hedger

Endocrinology· April 2019

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Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.
Rukmali Wijayarathna, David M de Kretser, Andreas Meinhardt, Ralf Middendorff, Helen Ludlow, Mark P Hedger

Mol Cell Endocrinol· July 2018

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Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice?
Monika Fijak, Adrian Pilatz, Mark P Hedger, Nour Nicolas, Sudhanshu Bhushan

Hum Reprod Update· July 2018

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Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.
Kieren D Marini, David R Croucher, Rachael A McCloy, Vijesh Vaghjiani, Alvaro Gonzalez-Rajal, Mark P Hedger

Sci Transl Med· July 2018

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Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection.
Alice M Richardson, Don P Lewis, Badia Kita, Helen Ludlow, Nigel P Groome, Mark P Hedger

J Transl Med· April 2018

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Epididymal cysteine-rich secretory proteins are required for epididymal sperm maturation and optimal sperm function.
Jinghua Hu, D Jo Merriner, Anne E O'Connor, Brendan J Houston, Luc Furic, Mark P Hedger

Mol Hum Reprod· March 2018

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Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond.
Kate L Loveland, Britta Klein, Dana Pueschl, Sivanjah Indumathy, Martin Bergmann, Mark P Hedger

Front Endocrinol (Lausanne)· November 2017

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