Publications by authors named "Mark Penney"

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Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design.
Peng Zhao, John Schardt, Chi-I Chiang, Pooja Shah, Gee Sung Eun, Mark Penney

MAbs· December 2025

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Predicting the Pharmacokinetics of T-Cell Engagers as a Function of Target-Mediated Drug Disposition.
Mark Penney, Alberto Ippolito, Elisa Fevola, Scott Rata, Liam Brown

Clin Transl Sci· November 2025

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A mechanistic PK/PD model of AZD0171 (anti-LIF) to support Phase II dose selection.
Azar Shahraz, Mark Penney, Juliana Candido, Grace Opoku-Ansah, Melanie Neubauer

CPT Pharmacometrics Syst Pharmacol· October 2024

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BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development.
Lien Dejager, Sophia Banton, Patricia Marques, Gabriela Rinikova, Sabrina Lory, Mark Penney

Bioanalysis· June 2024

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Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C1-C interface.
John D Bagert, Vaheh Oganesyan, Chi-I Chiang, Mike Iannotti, Jia Lin, Mark Penney

MAbs· November 2023

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
Elizabeth England, D Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T Y Chan, Mark Penney

Sci Rep· June 2023

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"Hot-spotting" to improve vaccine allocation by harnessing digital contact tracing technology: An application of percolation theory.
Mark D Penney, Yigit Yargic, Lee Smolin, Edward W Thommes, Madhur Anand

PLoS One· November 2021

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Recombinant sclerostin inhibits bone formation and in a mouse model of sclerosteosis.
Timothy Dreyer, Mittal Shah, Carl Doyle, Kevin Greenslade, Mark Penney

J Orthop Translat· July 2021

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Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery.
Mari Davies, Prabha Peramuhendige, Lloyd King, Melanie Golding, Apoorva Kotian, Mark Penney

Drug Metab Dispos· November 2020

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Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.
Erica L Bradshaw, Mary E Spilker, Richard Zang, Loveleena Bansal, Handan He, Mark Penney

CPT Pharmacometrics Syst Pharmacol· November 2019

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Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.
Lourdes Cucurull-Sanchez, Michael J Chappell, Vijayalakshmi Chelliah, S Y Amy Cheung, Gianne Derks, Mark Penney

CPT Pharmacometrics Syst Pharmacol· May 2019

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Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Marjoleen J M A Nijsen, Fan Wu, Loveleena Bansal, Erica Bradshaw-Pierce, Jason R Chan, Mark Penney

CPT Pharmacometrics Syst Pharmacol· March 2018

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A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease.
Peter M A Calverley, Sanjay Sethi, Michelle Dawson, Christine K Ward, Donna K Finch, Mark Penney

Respir Res· August 2017

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Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn's Disease: A Phase 2a Study.
Bruce E Sands, Jingjing Chen, Brian G Feagan, Mark Penney, William A Rees

Gastroenterology· July 2017

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Structural and functional characterization of a specific antidote for ticagrelor.
Andrew Buchanan, Philip Newton, Susanne Pehrsson, Tord Inghardt, Thomas Antonsson, Mark Penney

Blood· May 2015

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At the bench: the key role of PK-PD modelling in enabling the early discovery of biologic therapies.
Mark Penney, Balaji Agoram

Br J Clin Pharmacol· May 2014

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Prevalence of lymphoreticular prion protein accumulation in UK tissue samples.
David A Hilton, Azra C Ghani, Lisa Conyers, Philip Edwards, Linda McCardle, Mark Penney

J Pathol· July 2004

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Accumulation of prion protein in tonsil and appendix: review of tissue samples.
David A Hilton, Azra C Ghani, Lisa Conyers, Philip Edwards, Linda McCardle, Mark Penney

BMJ· September 2002

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Evaluation of molecular markers in low-grade diffuse astrocytomas: loss of p16 and retinoblastoma protein expression is associated with short survival.
David A Hilton, Mark Penney, Barry Evans, Hilary Sanders, Seth Love

Am J Surg Pathol· April 2002

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