Publications by authors named "Marscha Hirschi"

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Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD metabolism.
Qian Zhang, Huimin Zhang, Marscha Hirschi, Sheng Li, Gabriel C Lander

bioRxiv· September 2025

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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson

Nat Chem Biol· March 2025

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Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.
Bernhard Kuhle, Marscha Hirschi, Lili K Doerfel, Gabriel C Lander, Paul Schimmel

Nat Commun· August 2023

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Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Bernhard Kuhle, Marscha Hirschi, Lili K Doerfel, Gabriel C Lander, Paul Schimmel

Nat Commun· August 2022

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A case for glycerol as an acceptable additive for single-particle cryoEM samples.
Benjamin Basanta, Marscha M Hirschi, Danielle A Grotjahn, Gabriel C Lander

Acta Crystallogr D Struct Biol· January 2022

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AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.
Marscha Hirschi, Wang-Ting Lu, Andrew Santiago-Frangos, Royce Wilkinson, Sarah M Golden

Nat Commun· June 2020

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Conformational ensemble of the human TRPV3 ion channel.
Lejla Zubcevic, Mark A Herzik, Mengyu Wu, William F Borschel, Marscha Hirschi

Nat Commun· November 2018

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Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Marscha Hirschi, Mark A Herzik, Jinhong Wie, Yang Suo, William F Borschel

Nature· October 2017

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Visualizing multistep elevator-like transitions of a nucleoside transporter.
Marscha Hirschi, Zachary Lee Johnson, Seok-Yong Lee

Nature· May 2017

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Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.
Sudharshan Eathiraj, Rocio Palma, Erika Volckova, Marscha Hirschi, Dennis S France

J Biol Chem· June 2011

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A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
Sudharshan Eathiraj, Rocio Palma, Marscha Hirschi, Erika Volckova, Enkeleda Nakuci

J Biol Chem· June 2011

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Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms.
Annemieke Aartsma-Rus, Laura van Vliet, Marscha Hirschi, Anneke A M Janson, Hans Heemskerk

Mol Ther· March 2009

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