Publications by authors named "Marta Compte"

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Simultaneous secretion of a PD-L1 x 4-1BB bispecific antibody improves antileukemic efficacy of STAb-T cells secreting a CD19-specific T-cell engager.
Marina Gómez-Rosel, Laura Rubio-Pérez, Ivana Zagorac, Carmen Domínguez-Alonso, Laura Díez-Alonso, Marta Compte

Oncoimmunology· December 2025

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Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation.
Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Marta Compte

Front Immunol· May 2025

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Pharmacokinetics and safety of LEAD-452, an EGFR-specific 4-1BB-agonistic trimerbody in non-human primates.
Rocío Navarro, Susana Frago, Oana Hangiu, Ainhoa Erce-Llamazares, Rodrigo Lázaro-Gorines, Marta Compte

Toxicol Appl Pharmacol· June 2024

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Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses.
Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Marta Compte

Oncoimmunology· April 2024

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Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity.
Laura Rubio-Pérez, Susana Frago, Marta Compte, Rocío Navarro, Seandean L Harwood

Antibodies (Basel)· April 2024

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Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.
Rodrigo Lázaro-Gorines, Patricia Pérez, Ignacio Heras-Murillo, Irene Adán-Barrientos, Guillermo Albericio, Marta Compte

Adv Sci (Weinh)· December 2023

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A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.
Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L Harwood, Marta Compte, Rocío Navarro

Oncoimmunology· May 2023

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When three is not a crowd: trispecific antibodies for enhanced cancer immunotherapy.
Antonio Tapia-Galisteo, Marta Compte, Luis Álvarez-Vallina, Laura Sanz

Theranostics· February 2023

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Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo

iScience· September 2022

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Applications of trimerbodies in cancer immunotherapy.
Marta Compte, Laura Sanz, Luis Álvarez-Vallina

Int Rev Cell Mol Biol· July 2022

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Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.
Antonio Tapia-Galisteo, Íñigo Sánchez Rodríguez, Oscar Aguilar-Sopeña, Seandean Lykke Harwood, Javier Narbona, Marta Compte

Oncoimmunology· April 2022

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Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers.
Belén Blanco, Ángel Ramírez-Fernández, Clara Bueno, Lidia Argemí-Muntadas, Patricia Fuentes, Marta Compte

Cancer Immunol Res· April 2022

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Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR.
Marta Compte, Seandean L Harwood, Jorge Martínez-Torrecuadrada, Gema Perez-Chacon, Patricia González-García

Front Immunol· July 2021

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An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity.
Marta Compte, Seandean L Harwood, Ainhoa Erce-Llamazares, Antonio Tapia-Galisteo, Eduardo Romero

Clin Cancer Res· June 2021

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TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.
Rocío Navarro, Antonio Tapia-Galisteo, Laura Martín-García, Carlos Tarín, Cesáreo Corbacho, Marta Compte

Mol Oncol· October 2020

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Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies.
Kasper Mikkelsen, Seandean Lykke Harwood, Marta Compte, Nekane Merino, Kasper Mølgaard

Front Immunol· September 2020

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Immuno-PET Imaging and Pharmacokinetics of an Anti-CEA scFv-based Trimerbody and Its Monomeric Counterpart in Human Gastric Carcinoma-Bearing Mice.
Xabier Rios, Marta Compte, Vanessa Gómez-Vallejo, Unai Cossío, Zuriñe Baz

Mol Pharm· March 2019

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T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies.
Belén Blanco, Marta Compte, Simon Lykkemark, Laura Sanz, Luis Alvarez-Vallina

Trends Immunol· March 2019

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A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.
Marta Compte, Seandean Lykke Harwood, Ines G Muñoz, Rocio Navarro, Manuela Zonca

Nat Commun· November 2018

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Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.
Kasper Mølgaard, Seandean L Harwood, Marta Compte, Nekane Merino, Jaume Bonet

Cancer Immunol Immunother· August 2018

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ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy.
Seandean Lykke Harwood, Ana Alvarez-Cienfuegos, Natalia Nuñez-Prado, Marta Compte, Sara Hernández-Pérez

Oncoimmunology· September 2017

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Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity.
Rocío Navarro, Marta Compte, Luis Álvarez-Vallina, Laura Sanz

Front Immunol· November 2016

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Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains.
Ana Alvarez-Cienfuegos, Natalia Nuñez-Prado, Marta Compte, Angel M Cuesta, Ana Blanco-Toribio

Sci Rep· June 2016

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Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation.
Rocío Navarro, Pablo Delgado-Wicke, Natalia Nuñez-Prado, Marta Compte, Ana Blanco-Toribio

J Cell Mol Med· May 2016

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Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies.
Ana Blanco-Toribio, Ana Álvarez-Cienfuegos, Noelia Sainz-Pastor, Nekane Merino, Marta Compte

AMB Express· December 2015

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