Publications by authors named "Martin Domalski"

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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.
Dmitri A Pissarnitski, Zhiqiang Zhao, David Cole, Wen-Lian Wu, Martin Domalski

Bioorg Med Chem· November 2016

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Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
Wen-Lian Wu, Jinsong Hao, Martin Domalski, Duane A Burnett, Dmitri Pissarnitski

ACS Med Chem Lett· May 2016

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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Wen-Lian Wu, Theodros Asberom, Thomas Bara, Chad Bennett, Duane A Burnett, Martin Domalski

Bioorg Med Chem Lett· February 2013

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A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors.
Wen-Lian Wu, Thavalakulamgara K Sasikumar, Martin S Domalski, Li Qiang, Duane A Burnett

Bioorg Med Chem Lett· February 2013

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Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.
Stephanie Brumfield, Peter Korakas, Lisa S Silverman, Deen Tulshian, Julius J Matasi, Martin Domalski

Bioorg Med Chem Lett· December 2012

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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.
Wen-Lian Wu, Martin Domalski, Duane A Burnett, Hubert Josien, Thomas Bara

ACS Med Chem Lett· November 2012

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Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Ruo Xu, David Cole, Ted Asberom, Tom Bara, Chad Bennett, Martin Domalski

Bioorg Med Chem Lett· April 2010

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Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.
Wen-Lian Wu, Duane A Burnett, Martin Domalski, William J Greenlee, Cheng Li

J Med Chem· November 2007

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Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.
Wen-Lian Wu, Duane A Burnett, Richard Spring, Li Qiang, Thavalakulamgara K Sasikumar, Martin S Domalski

Bioorg Med Chem Lett· July 2006

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Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
Wen-Lian Wu, Duane A Burnett, Mary Ann Caplen, Martin S Domalski, Chad Bennett

Bioorg Med Chem Lett· July 2006

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Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.
Wen-Lian Wu, Mary Ann Caplen, Martin S Domalski, Hongtao Zhang, Ahmad Fawzi

Bioorg Med Chem Lett· November 2002

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Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
Duane A Burnett, Mary Ann Caplen, Martin S Domalski, Margaret E Browne, Harry R Davis

Bioorg Med Chem Lett· February 2002

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