Publications by authors named "Martin Empting"

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Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen.
Aylin Berwanger, Saskia Catherina Stein, Sarah Brandner, Andreas Martin Kany, Sebastian Heinz, Martin Empting

ChemMedChem· November 2025

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Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality.
Chelsea E Cunningham, Frederick S Vizeacoumar, Yue Zhang, Liliia Kyrylenko, Simon Both, Martin Empting

Cell Genom· June 2025

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Native Flow-Induced Dispersion Analysis - Mass Spectrometry Enables Automated, Multiplexed Ligand Screening from Conventional, Nonvolatile Buffers.
Edvaldo Vasconcelos Soares Maciel, Jonathan Eisert, Verena Dederer, Aylin Berwanger, Stefan Knapp, Martin Empting

Anal Chem· May 2025

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Native Taylor/Non-Taylor Dispersion-Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening.
Jonathan Eisert, Edvaldo Vasconcelos Soares Maciel, Verena Dederer, Aylin Berwanger, Henry J Bailey, Martin Empting

Small Methods· May 2025

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Tandem ketone reduction in pepstatin biosynthesis reveals an FH-dependent statine pathway.
Jingjun Mo, Asfandyar Sikandar, Haowen Zhao, Ghader Bashiri, Liujie Huo, Martin Empting

Nat Commun· May 2025

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Nanoparticles in liposomes: a platform for increased antibiotic selectivity in multidrug resistant bacteria in respiratory tract infections.
Nathalie E Fakhoury, Samar Mansour, Mohammad Abdel-Halim, Mostafa M Hamed, Martin Empting

Drug Deliv Transl Res· April 2025

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From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in .
Marie Thiemann, Moritz Zimmermann, Christina Diederich, Huilin Zhan, Mikhail Lebedev, Martin Empting

J Med Chem· April 2025

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Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa.
Georgios Kallergis, Ehsannedin Asgari, Martin Empting, Anna K H Hirsch, Frank Klawonn

Commun Chem· April 2025

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Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity.
Ahmed S Abdelsamie, Mostafa M Hamed, Christian Schütz, Teresa Röhrig, Andreas M Kany, Martin Empting

Eur J Med Chem· October 2024

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The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research.
Godfrey Mayoka, Daniel Krug, Brigitta Loretz, Kenan Bozhüyük, Martin Empting

Trends Microbiol· October 2024

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Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?
Noha Nafee, Dina M Gaber, Alaa Abouelfetouh, Mustafa Alseqely, Martin Empting

Int J Nanomedicine· May 2024

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Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Svenja M Sake, Xiaoyu Zhang, Manoj Kumar Rajak, Melanie Urbanek-Quaing, Arnaud Carpentier, Martin Empting

Nat Commun· February 2024

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Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target.
Shilpee Chanda, Konstantin Lepikhov, Charlotte Dahlem, Hanna S Schymik, Jessica Hoppstädter, Martin Empting

Front Biosci (Landmark Ed)· January 2024

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Thioxothiazolo[3,4-a]quinazoline derivatives inhibit the human cytomegalovirus alkaline nuclease.
Tianyu Zhang, Theodore I Potgieter, Erik Kosche, Jessica Rückert, Eleonore Ostermann, Martin Empting

Antiviral Res· September 2023

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Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors.
Yingwen Wu, Ben G E Zoller, Mohamed Ashraf Mostafa Kamal, Sven-Kevin Hotop, Claus-Michael Lehr, Martin Empting

Chembiochem· August 2023

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Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor.
Aylin Berwanger, Saskia C Stein, Andreas M Kany, Melissa Gartner, Brigitta Loretz, Martin Empting

J Med Chem· August 2023

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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas M Kany, Martin Empting

Adv Sci (Weinh)· February 2023

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Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages.
Svenja M Sake, Christina Kosch, Sebastian Blockus, Sibylle Haid, Antonia P Gunesch, Martin Empting

Antimicrob Agents Chemother· December 2022

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Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane.
Carla F Sousa, Mohamed A M Kamal, Robert Richter, Kalanika Elamaldeniya, Rolf W Hartmann, Martin Empting

J Chem Inf Model· October 2022

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NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.
Robert Creutznacher, Thorben Maass, Barbora Veselkova, George Ssebyatika, Thomas Krey, Martin Empting

J Am Chem Soc· July 2022

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Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA.
Valentin Jakob, Ben G E Zoller, Julia Rinkes, Yingwen Wu, Alexander F Kiefer, Martin Empting

Eur J Med Chem· March 2022

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First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy.
Charlotte Dahlem, Ali Abuhaliema, Sonja M Kessler, Tarek Kröhler, Ben G E Zoller, Martin Empting

ACS Chem Biol· February 2022

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Transferring Microclusters of Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin.
Justus C Horstmann, Annabelle Laric, Annette Boese, Daniela Yildiz, Teresa Röhrig, Martin Empting

ACS Infect Dis· January 2022

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Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.
Christian Schütz, Amir Hodzic, Mostafa Hamed, Ahmed S Abdelsamie, Andreas M Kany, Martin Empting

Eur J Med Chem· December 2021

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Towards the sustainable discovery and development of new antibiotics.
Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, Martin Empting

Nat Rev Chem· October 2021

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