Publications by authors named "Martin Leivers"

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Randomized clinical trials towards a single-visit cure for chronic hepatitis C: Oral GSK2878175 and injectable RG-101 in chronic hepatitis C patients and long-acting injectable GSK2878175 in healthy participants.
Yanli Deng, Fiona Campbell, Kelong Han, Dickens Theodore, Mark Deeg, Martin Leivers

J Viral Hepat· July 2020

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GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage.
Wieslaw M Kazmierski, Sam Baskaran, Jill T Walker, Nagaraju Miriyala, Ramu Meesala, Martin R Leivers

J Med Chem· April 2020

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A Randomized, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects.
Kelong Han, Jennifer Cremer, Robert Elston, Stuart Oliver, Sharon Baptiste-Brown, Martin Leivers

Clin Pharmacol Drug Dev· August 2019

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Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
Andrew Maynard, Renae M Crosby, Byron Ellis, Robert Hamatake, Zhi Hong, Anna Leivers, Martin R Leivers

J Med Chem· March 2014

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Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.
Anna L Leivers, Matthew Tallant, J Brad Shotwell, Scott Dickerson, Martin R Leivers

J Med Chem· March 2014

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Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism.
Martin Leivers, John F Miller, Stephanie A Chan, Ryan Lauchli, Sebastian Liehr

J Med Chem· March 2014

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Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound.
Wieslaw M Kazmierski, Andrew Maynard, Maosheng Duan, Sam Baskaran, Janos Botyanszki, Martin Leivers

J Med Chem· March 2014

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Synthesis of HCV replicase inhibitors: base-catalyzed synthesis of protected α-hydrazino esters and selective aerobic oxidation with catalytic Pt/Bi/C for synthesis of imidazole-4,5-dicarbaldehyde.
Roy K Bowman, Andrew D Brown, Jannine H Cobb, John F Eaddy, Mark A Hatcher, Martin R Leivers

J Org Chem· December 2013

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A forbidden rearrangement.
Martin Leivers, Iris Tam, Kevin Groves, David Leung, Yuli Xie

Org Lett· September 2003

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